Evaluating T Cell Changes in Lung Cancer with PET Imaging

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial assesses the effectiveness of two novel PET tracers in evaluating T cell changes and activation in patients with non-small cell lung cancer (NSCLC) following chemo-immunotherapy. Participants will undergo two PET scans before their scheduled surgery, allowing researchers to compare the imaging results of the tracers against the pathological analysis of the resected tumor. The goal is to enhance understanding of how these imaging biomarkers can provide insights into treatment responses.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Histologically confirmed NSCLC
* T1-4N0-2, lesion size of ≥2cm, at time of the restaging FDG PET/CT
* Planned to undergo resection after chemo-IO according to routine treatment guidelines
* Willing and able to provide written informed consent for the trial
* Above 18 years of age on day of signing informed consent
* Have measurable disease based on RECIST 1.1
* Have a ECOG performance status of 0-1, and are considered operable based on pulmonary function test and/or exercise testing

Exclusion Criteria:

* Patients deemed inoperable
* Patients who have received a splenectomy
* Patients who have received any vaccination within 14 days of enrollment
* Patients with a condition requiring systemic treatment with either corticosteroids (\> 10 mg daily prednisone equivalent) or other immunosuppressive medications within 14 days of day 0. Inhaled or topical steroids, and adrenal replacement steroid \>10 mg daily prednisone equivalent, are permitted in the absence of active autoimmune disease.
* Psychiatric or substance abuse disorders that would interfere with cooperation with the requirements of the trial.
* Patient is pregnant or breastfeeding or expecting to conceive within the projected duration of the trial.

Where it's running

• Amsterdam UMC, location VUmc
  Amsterdam, North Holland, Netherlands Recruiting

Study contacts

• Principal investigator: Idris Bahce, MD, PhD — Amsterdam UMC
• Study coordinator: Maarten Slebe, Msc.
• Email: m.slebe@amsterdamumc.nl
• Phone: +31204445242

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.