Preventing constipation caused by opioids in advanced cancer patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to evaluate the effectiveness of magnesium hydroxide compared to macrogol/electrolytes in preventing opioid-induced constipation (OIC) in patients with advanced cancer who are starting opioid treatment for pain management. Given that OIC affects a significant portion of cancer patients, the study will assess the tolerability and efficacy of these treatments in improving patient quality of life. Participants will be required to complete a questionnaire in Dutch to assess their symptoms and treatment outcomes. The study is designed to provide insights into a less commonly used laxative option that may be more acceptable to patients due to its neutral taste.

Why it matters

Who can join: the full rules

Inclusion criteria:

In order to be eligible to participate in this study, a subject must meet all of the following criteria:

* Patients with advanced cancer (≥18 years);
* Starting with slow release or transdermal opioids for pain;
* Able to complete a Dutch questionnaire. Previous treatment with opioids is allowed, if discontinued more than 4 weeks ago.

Exclusion Criteria:

A potential subject who meets any of the following criteria will be excluded from participation in this study:

* Patients with contra-indications for laxatives
* Maintenance treatment with laxatives during the last 14 days
* Severely impaired renal function (serum creatinine \>180 umol/l)
* Estimated life expectancy \<1 month

Where it's running

• Flevoziekenhuis
  Almere Stad, Flevoland, Netherlands Recruiting
• Rijnstate Ziekenhuis
  Arnhem, Gelderland, Netherlands Recruiting
• Radboud university Medical center Nijmegen
  Nijmegen, Gelderland, Netherlands Recruiting
• Jeroen Bosch Ziekenhuis
  's-Hertogenbosch, North Brabant, Netherlands Recruiting
• Amsterdam UMC, location VUmc
  Amsterdam, North Holland, Netherlands Recruiting
• Spaarne Gasthuis
  Hoofddorp, North Holland, Netherlands Recruiting

Study contacts

• Principal investigator: Lia van Zuylen, Prof.dr. — Amsterdam UMC, location VUmc
• Study coordinator: Kay Kistemaker, MSc/MD
• Email: k.kistemaker@amsterdamumc.nl
• Phone: +31 6 50087799

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.