Sponsor or institution

Clinical trials and research at Abramson Cancer Center at Penn Medicine

• 71Clinical trials
• 2Countries

Newest trials

All recruiting trials (71)

• DNP-MRSI to predict HCC treatment response

  This study tests whether DNP-MRSI imaging of hyperpolarized 1-13C-pyruvate uptake and metabolism in liver tumors can indicate which BCLC A–C HCC lesions will respond after locoregional therapies or systemic treatment.

  Recruiting Abramson Cancer Center at Penn Medicine · Philadelphia, Pennsylvania · NCT07807475

• Pemefolacianine imaging for lung cancer surgery

  A first-in-human dose study tests a new fluorescent imaging agent given before lung cancer surgery to see if it is safe and helps highlight tissue during thoracoscopy or robotic surgery.

  Recruiting Phase 1 Abramson Cancer Center at Penn Medicine · Philadelphia, Pennsylvania · NCT07772895

• Low Dose Radiotherapy for Osteoarthritis

  This study tests whether low-dose radiotherapy can help reduce pain and improve function for adults with osteoarthritis who have not benefited from standard treatments.

  Recruiting at 2 sites Abramson Cancer Center at Penn Medicine · Philadelphia, Pennsylvania and 1 other locations · NCT07715188

• TumorGlow use during surgery to see sarcoma lung metastases in children

  This pediatric study tests a single 5 mg/kg dose of TumorGlow (ICG) given before surgery to help doctors see sarcoma metastases in the lungs during tumor removal.

  Recruiting Early Phase 1 Abramson Cancer Center at Penn Medicine · Phildelphia, Pennsylvania · NCT07658768

• Lifestyle and energy balance in breast cancer survivorship

  This study tests how diet, physical activity, and urinary metabolites relate to lifestyle changes in women newly diagnosed with breast cancer during treatment and survivorship.

  Recruiting Abramson Cancer Center at Penn Medicine · Philadelphia, Pennsylvania · NCT07655934

• Radiation, Vancomycin, and CAR-T for B-Cell Lymphoma

  This trial tests if giving radiation and the antibiotic vancomycin before CAR-T cell therapy is feasible for adults with large B-cell lymphomas.

  Recruiting Phase 1 Abramson Cancer Center at Penn Medicine · Philadelphia, Pennsylvania · NCT07478848

• Remote genetic counseling with optional digital tools for hereditary cancer testing

  This project will test telehealth and optional digital tools to deliver pre-test education and result disclosure for adults who qualify for hereditary cancer genetic testing.

  Recruiting Abramson Cancer Center at Penn Medicine · Philadelphia, Pennsylvania · NCT07471958

• Engaging mobile health for symptom monitoring and health promotion during endocrine therapy

  This trial tests a digital, phone-based program to help women on endocrine therapy for breast cancer track symptoms, stay adherent to treatment, and stay on therapy as prescribed.

  Recruiting Abramson Cancer Center at Penn Medicine · Philadelphia, Pennsylvania · NCT07454499

• CYTALUX-guided near-infrared imaging during surgery for endometrial cancer

  This will test whether giving CYTALUX dye before planned laparoscopic surgery and using a special near-infrared camera helps surgeons find endometrial cancer lesions.

  Recruiting at 2 sites Early Phase 1 Abramson Cancer Center at Penn Medicine · Philadelphia, Pennsylvania and 1 other locations · NCT07278986

• Erector spinae plane block for abdominal pain from gastrointestinal cancer

  This study will try an erector spinae plane nerve block to reduce severe abdominal pain and opioid use in adults with gastrointestinal cancers who come to Penn Medicine emergency departments.

  Recruiting at 4 sites Abramson Cancer Center at Penn Medicine · Philadelphia, Pennsylvania and 3 other locations · NCT07211386

• Choice-based harm-reduction sampling to help people not ready to quit smoking

  This project will test whether letting smokers who aren't ready to quit choose and try a harm-reduction product (an e-cigarette or a nicotine pouch) leads to less cigarette use over six months than giving a nicotine patch plus lozenge.

  Recruiting Abramson Cancer Center at Penn Medicine · Philadelphia, Pennsylvania · NCT07199517

• Five-day radiation for children and young adults with incurable brain cancers

  This will try a shorter, five-day course of radiation for children and young adults (21 and under) with incurable central nervous system cancers to see if it is safe and improves quality of life.

  Recruiting Abramson Cancer Center at Penn Medicine · Philadelphia, Pennsylvania · NCT07147179

• Remove incorrect beta-lactam (penicillin and cephalosporin) allergy labels to expand antibiotic options for patients with blood cancers.

  This project tests a pharmacist-led process to remove incorrect penicillin or other beta-lactam allergy labels in hospitalized patients with blood cancers so they can receive preferred antibiotics and potentially have better outcomes.

  Recruiting Phase 4 Abramson Cancer Center at Penn Medicine · Philadelphia, Pennsylvania · NCT07133074

• FTT PET/CT imaging to detect PARP‑1 in pancreatic neuroendocrine tumors

  This pilot will test whether an experimental PET tracer called [18F]FTT can show PARP‑1 activity in adults with metastatic or unresectable grade 1–3 pancreatic neuroendocrine tumors.

  Recruiting Phase 1 Abramson Cancer Center at Penn Medicine · Philadelphia, Pennsylvania · NCT07114939

• Telehealth collaborative care program for lung cancer-related anxiety and depression

  This project tests whether a more intensive 'high-touch' outreach approach gets more people with lung cancer who have anxiety or depression to join a telehealth collaborative care program than standard outreach.

  Recruiting Abramson Cancer Center at Penn Medicine · Philadelphia, Pennsylvania · NCT07102147

• Pembrolizumab plus odetiglucan for liver‑predominant metastatic colorectal adenocarcinoma

  This will test whether pembrolizumab combined with odetiglucan is safe and helps adults whose colorectal cancer has spread mainly to the liver after standard chemotherapy and targeted drugs.

  Recruiting Phase 2 Abramson Cancer Center at Penn Medicine · Philadelphia, Pennsylvania · NCT07082439

• At-home BCG treatment with digital support for bladder cancer

  This will try giving BCG at home plus a conversational app for adults with non‑muscle invasive bladder cancer to track symptoms and help them stick with treatment.

  Recruiting Abramson Cancer Center at Penn Medicine · Philadelphia, Pennsylvania · NCT07048496

• Just ASK™ training to increase provider conversations about breast cancer clinical trials

  This pilot tests whether Just ASK™ training helps oncology clinic teams at Abramson Cancer Center have more conversations with eligible breast cancer patients about joining clinical trials.

  Recruiting Abramson Cancer Center at Penn Medicine · Plainsboro, New Jersey · NCT07040891

• Examining the role of vaginal microbiome in ovarian cancer detection

  This study is trying to see if the bacteria in the vagina can help detect ovarian cancer earlier by comparing samples from healthy women and those at higher risk or already diagnosed.

  Recruiting Abramson Cancer Center at Penn Medicine · Philadelphia, Pennsylvania · NCT06962059

• Photobiomodulation for chronic head and neck lymphedema

  This will test whether photobiomodulation (low-level laser) can reduce chronic lymphedema in people who were treated for head and neck cancer.

  Recruiting at 2 sites Abramson Cancer Center at Penn Medicine · Philadelphia, Pennsylvania and 1 other locations · NCT06837480

• Total Consolidative Metastasis and Primary-directed Therapy for Renal Cell Carcinoma

  This study tests whether giving a one-time consolidative treatment to all detectable disease, then stopping systemic therapy, can keep people with metastatic clear cell RCC progression-free for 12 months after at least 6 months of immune therapy.

  Recruiting Abramson Cancer Center at Penn Medicine · Philadelphia, Pennsylvania · NCT06770855

• Combining Niraparib and Ipilimumab for Metastatic Pancreatic Cancer Treatment

  This study is testing if combining two treatments, niraparib and ipilimumab, can help people with metastatic pancreatic cancer whose disease hasn't worsened after chemotherapy.

  Recruiting at 2 sites Phase 2 Abramson Cancer Center at Penn Medicine · Boston, Massachusetts and 1 other locations · NCT06747845

• Lidocaine injection before surgery for oropharyngeal cancer

  This study tests if giving a lidocaine injection before surgery can help improve outcomes for patients with oropharyngeal cancer.

  Recruiting Phase 1 Abramson Cancer Center at Penn Medicine · Philadelphia, Pennsylvania · NCT06747390

• Safe and explainable AI to help doctors with heart disease, sepsis, and breast cancer care

  This project will try AI tools that give safe, explainable decision support for adults treated for cardiology conditions, sepsis, or invasive breast cancer at Penn Medicine.

  Recruiting Abramson Cancer Center at Penn Medicine · Philadelphia, Pennsylvania · NCT06694181

• Biobank for prostate tissue samples and genetic data

  This study is collecting prostate tissue samples and DNA from men with inherited gene mutations to see how these genetic factors affect prostate cancer and treatment responses compared to men without these mutations.

  Recruiting Abramson Cancer Center at Penn Medicine · Philadelphia, Pennsylvania · NCT06659614

• Using telehealth to improve lung cancer screening decision-making

  This study tests if using telehealth can help patients make better decisions about lung cancer screening and ensure everyone has equal access to this important care.

  Recruiting Abramson Cancer Center at Penn Medicine · Philadelphia, Pennsylvania · NCT06638554

• Metabolic profiling of glioblastoma using advanced imaging techniques

  This study is testing new imaging techniques to see how glioblastoma tumors use energy and nutrients, which could help doctors understand the tumors better and improve treatment options.

  Recruiting at 2 sites Early Phase 1 Abramson Cancer Center at Penn Medicine · Philadelphia, Pennsylvania and 1 other locations · NCT06613841

• Using BHB with CAR-T therapy for lymphoma treatment

  This study is testing if taking a supplement called BHB while getting CAR-T therapy for large B-cell lymphoma can be safe and help improve the treatment's effects on the body.

  Recruiting Abramson Cancer Center at Penn Medicine · Philadelphia, Pennsylvania · NCT06610344

• Proton therapy with a brachytherapy boost for high-risk prostate cancer

  This study is testing a new way to treat high-risk prostate cancer using a special type of radiation therapy combined with a targeted boost to see if it works better and causes less harm to healthy tissue.

  Recruiting Phase 2 Abramson Cancer Center at Penn Medicine · Philadelphia, Pennsylvania · NCT06591819

• Combining immunotherapy and radiation for bladder cancer treatment

  This study is testing if giving immunotherapy and radiation together is safe for people with bladder cancer who have had surgery.

  Recruiting Phase 1 Abramson Cancer Center at Penn Medicine · Philadelphia, Pennsylvania · NCT06586255

• Measuring HER2 levels in metastatic breast cancer patients

  This study is testing a new way to measure HER2 levels in patients with low HER2 metastatic breast cancer to see if it can help identify who will benefit from a specific treatment.

  Recruiting at 37 sites Abramson Cancer Center at Penn Medicine · San Francisco, California and 36 other locations · NCT06551116

• Epcoritamab treatment for certain types of lymphoma

  This study is testing if adding a new treatment called epcoritamab to CAR T cell therapy can help people with certain types of lymphoma who haven't fully responded to previous treatments.

  Recruiting Phase 2 Abramson Cancer Center at Penn Medicine · Philadelphia, Pennsylvania · NCT06458439

• Polygenic Risk Scores and Early Detection for Ovarian Cancer in BRCA1/2 Carriers

  This study tests how women with BRCA1/2 mutations feel about using polygenic risk scores and early-detection tests to guide cancer screening and risk-reducing decisions.

  Recruiting Abramson Cancer Center at Penn Medicine · Philadelphia, Pennsylvania · NCT06436248

• Imaging fibrosis in adults using FAPI-74 PET/CT

  This study is testing a new imaging method to see if a special scan can help find fibrosis in adults with different health conditions.

  Recruiting Phase 1 Abramson Cancer Center at Penn Medicine · Philadelphia, Pennsylvania · NCT06413355

• Evaluating e-cigarettes and nicotine pouches for smokers

  This study is testing whether e-cigarettes or nicotine pouches can help long-term smokers quit regular cigarettes and reduce their smoking habits over six weeks.

  Recruiting Abramson Cancer Center at Penn Medicine · Philadelphia, Pennsylvania · NCT06372899

• Evaluating how flavor affects smokers switching to e-cigarettes

  This study tests whether different e-cigarette flavors can help smokers switch from regular cigarettes to e-cigarettes more easily.

  Recruiting Abramson Cancer Center at Penn Medicine · Philadelphia, Pennsylvania · NCT06264154

• Self-management program for lymphedema in head and neck cancer survivors

  This study is testing a self-management program for lymphedema in head and neck cancer survivors to see if in-person or telehealth support helps them feel better compared to usual care.

  Recruiting at 2 sites Abramson Cancer Center at Penn Medicine · Philadelphia, Pennsylvania and 1 other locations · NCT06125743

• Using AI to improve diagnosis of lung nodules

  This study is testing if a new computer tool can help doctors better diagnose lung nodules in adults and improve their treatment decisions.

  Recruiting at 3 sites Abramson Cancer Center at Penn Medicine · Philadelphia, Pennsylvania and 2 other locations · NCT05968898

• Improving cervical cancer treatment access in Botswana

  This study is trying out new ways to help women in Botswana get cervical cancer treatment more quickly and easily.

  Recruiting at 2 sites Abramson Cancer Center at Penn Medicine · Philadelphia, Pennsylvania and 2 other locations · NCT05952141

• Limited-duration treatment with teclistamab for multiple myeloma

  This study is testing if a short-term treatment with teclistamab can help people with multiple myeloma keep their positive response after standard therapy without needing to stay on treatment continuously.

  Recruiting at 5 sites Phase 2 Abramson Cancer Center at Penn Medicine · Little Rock, Arkansas and 4 other locations · NCT05932680

• Using PET imaging to evaluate estrogen receptor activity in uterine cancer

  This study is testing a special type of imaging to see how well estrogen receptors are working in women with recurrent or advanced uterine cancer to help guide their treatment.

  Recruiting Phase 2 Abramson Cancer Center at Penn Medicine · Philadelphia, Pennsylvania · NCT05916196

• Evaluating the impact of geriatric assessments on treatment for older AML patients

  This study is testing if a thorough health check for older adults with newly diagnosed acute myeloid leukemia can help doctors choose better treatments and improve their chances of recovery.

  Recruiting Abramson Cancer Center at Penn Medicine · Philadelphia, Pennsylvania · NCT05909501

• Proton therapy for treating gynecologic cancer after surgery

  This study is testing a new type of radiation therapy after surgery to see if it helps women with cervical and endometrial cancer while causing fewer side effects.

  Recruiting at 3 sites Phase 2 Abramson Cancer Center at Penn Medicine · Voorhees Township, New Jersey and 2 other locations · NCT05758688

• Collecting blood samples to study biomarkers in pancreatic cancer

  This study is collecting blood samples from patients with pancreatic cancer to see if certain markers in the blood can help improve diagnosis and treatment options.

  Recruiting Abramson Cancer Center at Penn Medicine · Philadelphia, Pennsylvania · NCT05743049

• Using pembrolizumab and lenvatinib to treat kidney cancer before surgery

  This study is testing if a combination of two drugs, pembrolizumab and lenvatinib, can help treat kidney cancer before surgery to see how well they work together.

  Recruiting Early Phase 1 Abramson Cancer Center at Penn Medicine · Philadelphia, Pennsylvania · NCT05733715

• Assessing quality of life and muscle loss in patients with fluid buildup in the abdomen

  This study is trying to see how fluid buildup in the abdomen affects the quality of life and muscle loss in patients over time.

  Recruiting Abramson Cancer Center at Penn Medicine · Philadelphia, Pennsylvania · NCT05726747

• Imaging for newly diagnosed breast cancer using a novel device

  This study is testing a new imaging method for people with newly diagnosed estrogen-receptor positive breast cancer to see if it provides better information about their disease compared to standard imaging techniques.

  Recruiting Early Phase 1 Abramson Cancer Center at Penn Medicine · Philadelphia, Pennsylvania · NCT05659797

• Evaluating PARP-1 Expression in Pheochromocytoma and Paraganglioma Using PET/CT Imaging

  This study is testing a new imaging method to see how a specific protein is expressed in tumors of patients with pheochromocytoma or paraganglioma before they receive treatment.

  Recruiting Early Phase 1 Abramson Cancer Center at Penn Medicine · Philadelphia, Pennsylvania · NCT05636540

• Improving outcomes for older patients receiving allogeneic transplants through exercise

  This study is testing if a supervised exercise program can help older adults recover better after receiving a stem cell transplant.

  Recruiting Abramson Cancer Center at Penn Medicine · Philadelphia, Pennsylvania · NCT05612789

• Using pembrolizumab before surgery for Merkel cell carcinoma

  This study is testing if giving the drug pembrolizumab before surgery can help people with Merkel cell carcinoma by shrinking their tumors and reducing the chance of cancer coming back.

  Recruiting Phase 2 Abramson Cancer Center at Penn Medicine · Philadelphia, Pennsylvania · NCT05496036

• Combining radiation therapy with immunotherapy for liver cancer

  This study is testing a new treatment that combines radiation therapy with immunotherapy drugs to see if it can help people with advanced liver cancer who can't have surgery.

  Recruiting Phase 1 Abramson Cancer Center at Penn Medicine · Philadelphia, Pennsylvania · NCT05488522

• Examining the immune environment in different types of breast cancer

  This study looks at tissue samples from women with different types of breast cancer to see how the immune environment affects treatment responses.

  Recruiting Abramson Cancer Center at Penn Medicine · Philadelphia, Pennsylvania · NCT05396612

• Combining All-Trans Retinoic Acid and PD-1 Inhibition for Recurrent IDH-Mutant Glioma

  This study is testing if a combination of a vitamin A derivative and a cancer immunotherapy can help people with recurrent IDH-mutant glioma feel better and fight their tumors.

  Recruiting Phase 2 Abramson Cancer Center at Penn Medicine · Philadelphia, Pennsylvania · NCT05345002

• Using FTT PET/CT scans to evaluate PARP activity in metastatic prostate cancer

  This study is testing if a new type of scan can help see how active a certain protein is in men with metastatic prostate cancer before and after they start a new treatment.

  Recruiting Early Phase 1 Abramson Cancer Center at Penn Medicine · Philadelphia, Pennsylvania · NCT05242744

• Study on cancer risks linked to CTNNA1 gene mutations

  This study is trying to find out if certain gene changes in the CTNNA1 gene increase the risk of cancers like gastric and breast cancer for people who have these changes in their family.

  Recruiting Abramson Cancer Center at Penn Medicine · Philadelphia, Pennsylvania · NCT05126290

• Personalized delivery of tumor treating fields for glioblastoma patients

  This study is testing if a new way of mapping brain tumors can help glioblastoma patients using Optune treatment live longer and feel better compared to the standard method.

  Recruiting at 2 sites Abramson Cancer Center at Penn Medicine · Philadelphia, Pennsylvania and 1 other locations · NCT05086497

• Combining tocilizumab and atezolizumab for advanced lung cancer after previous treatments

  This study is testing if combining two medications, tocilizumab and atezolizumab, can help adults with advanced lung cancer that hasn't improved with previous treatments.

  Recruiting Phase 1/2 Abramson Cancer Center at Penn Medicine · Philadelphia, Pennsylvania · NCT04691817

• Using Abemaciclib and Hydroxychloroquine to Target Residual Breast Cancer Cells

  This study is testing if a combination of two approved medications, abemaciclib and hydroxychloroquine, can help reduce leftover breast cancer cells in patients' bone marrow.

  Recruiting Phase 2 Abramson Cancer Center at Penn Medicine · Philadelphia, Pennsylvania · NCT04523857

• Using advanced MRI to differentiate between cancerous and non-cancerous salivary gland tumors

  This study is testing if advanced MRI can help doctors tell the difference between cancerous and non-cancerous salivary gland tumors in patients who haven't started treatment yet.

  Recruiting Abramson Cancer Center at Penn Medicine · Philadelphia, Pennsylvania · NCT04452162

• Biobank for patients with Li-Fraumeni Syndrome and TP53 mutations

  This study is collecting health information and samples from people with Li-Fraumeni Syndrome and TP53 mutations, as well as their family members, to see how their genes affect cancer risk and to find better ways to screen for and treat these cancers.

  Recruiting at 2 sites Abramson Cancer Center at Penn Medicine · Philadelphia, Pennsylvania and 1 other locations · NCT04367246

• Combination therapy for Grade 2 liver-dominant neuroendocrine tumors

  This study is testing a new combination treatment of two drugs followed by a special radiation therapy to see if it helps people with Grade 2 liver-dominant neuroendocrine tumors live longer without their cancer getting worse.

  Recruiting Phase 2 Abramson Cancer Center at Penn Medicine · La Jolla, California and 4 other locations · NCT04339036

• Understanding autoimmunity in cancer patients treated with immune checkpoint inhibitors

  This study looks at how cancer treatments that boost the immune system might cause some patients to develop autoimmune issues, by collecting samples and data from those receiving these therapies.

  Recruiting Abramson Cancer Center at Penn Medicine · Philadelphia, Pennsylvania · NCT04119713

• Using a special imaging technique to evaluate breast cancer

  This study is testing a new imaging technique to see how well it works for people with breast cancer and to better understand different types of the disease.

  Recruiting Phase 1 Abramson Cancer Center at Penn Medicine · Philadelphia, Pennsylvania · NCT03863457

• Combining pembrolizumab with chemotherapy and surgery for malignant pleural mesothelioma

  This study is testing if adding a new drug called pembrolizumab to chemotherapy and surgery can help people with malignant pleural mesothelioma feel better and improve their treatment outcomes.

  Recruiting Phase 1 Abramson Cancer Center at Penn Medicine · Philadelphia, Pennsylvania · NCT03760575

• Assessing frailty to improve treatment for older patients with blood cancers

  This study is testing if checking how frail older patients with blood cancers are can help doctors choose better treatments for them.

  Recruiting Abramson Cancer Center at Penn Medicine · Philadelphia, Pennsylvania · NCT03680677

• Safety of combining antimicrobial therapy with precision radiation for lung cancer

  This study is testing if adding an antibiotic called vancomycin to a specific type of radiation treatment can safely help people with early-stage lung cancer.

  Recruiting Phase 1 Abramson Cancer Center at Penn Medicine · Philadelphia, Pennsylvania · NCT03546829

• Testing for cancer cells in the bone marrow of breast cancer survivors at risk of relapse

  This study is testing if checking for cancer cells in the bone marrow of women who have finished treatment for breast cancer can help identify those who might need extra therapy to prevent a relapse.

  Recruiting Abramson Cancer Center at Penn Medicine · Philadelphia, Pennsylvania · NCT02732171

• Evaluating screening methods for pancreatic cancer in high-risk patients

  This study is trying to see if special imaging tests like endoscopic ultrasound and MRI can help find pancreatic cancer earlier in people with certain genetic risks.

  Recruiting Abramson Cancer Center at Penn Medicine · Philadelphia, Pennsylvania · NCT02478892

• Registry for monitoring small kidney tumors

  This study is trying to see if watching small kidney tumors closely without immediate treatment is a safe and effective option for patients.

  Recruiting Abramson Cancer Center at Penn Medicine · Baltimore, Maryland · NCT02346435

• Transplanting frozen ovarian tissue to restore fertility

  This study is testing if transplanting frozen ovarian tissue can help women who have lost their fertility due to cancer treatments have children again.

  Recruiting Abramson Cancer Center at Penn Medicine · Philadelphia, Pennsylvania · NCT01870752

• Registry and biosample collection for cancer patients undergoing radiotherapy

  This study is collecting blood, urine, and tumor samples from cancer patients receiving radiotherapy to see how the treatment affects them and to help improve future care.

  Recruiting at 3 sites Abramson Cancer Center at Penn Medicine · Moorestown, New Jersey and 3 other locations · NCT01577251

Quick answers

How many clinical trials run by Abramson Cancer Center at Penn Medicine are recruiting right now?

71, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 2 countries. The most sites are in United States (71 trials), Botswana (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 11, Phase 1: 10, Early Phase 1: 7, Phase 1/2: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.

Describe your situation →