Clinical trial Recruiting at 1 site Interventional Ages 18 and up

Using advanced MRI to differentiate between cancerous and non-cancerous salivary gland tumors

Official title: Physiologic MR Imaging in Distinguishing Benign From Malignant Salivary Gland Tumors

Run by Abramson Cancer Center at Penn Medicine · NCT04452162 · Data updated 2026-11-12

This study is testing if advanced MRI can help doctors tell the difference between cancerous and non-cancerous salivary gland tumors in patients who haven't started treatment yet.

More Salivary Gland Cancer trials

Quick facts

Study typeInterventional
Ages18 Years and up
SexAll
Enrollment30 (estimated)
SponsorAbramson Cancer Center at Penn Medicine
Academic / other
Drugs / interventionsradiation
Locations1 site (Philadelphia, Pennsylvania)
StatusRecruiting
StartedAugust 25, 2020
Main results expectedJune 2026
Study endsJune 2026
Registry record updatedSeptember 9, 2025
Trial IDNCT04452162 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are individuals with a salivary gland lesion of at least 1cm3 who have not received prior treatment for their condition.

Probably not a fit

Patients with a history of other cancers, MRI contraindications, renal disease, prior radiation to the head and neck, or who are pregnant may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to utilize advanced Magnetic Resonance Imaging (MRI) techniques to distinguish between benign and malignant salivary gland tumors. A total of 30 treatment-naïve patients with suspected salivary gland tumors will undergo a comprehensive MRI protocol that includes both anatomical imaging and dynamic contrast-enhanced imaging. The study will analyze specific imaging parameters to improve treatment strategies and predict disease progression based on the tumor's characteristics.

Why it matters

Potential benefit: If successful, this study could lead to more accurate diagnoses and tailored treatment plans for patients with salivary gland tumors.

How similar studies have gone: While the approach of using advanced MRI techniques is promising, it is relatively novel and has not been extensively tested in similar studies.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Possess a salivary gland lesion of 1cm3 size
* Have no prior history of treatment for salivary gland lesion

Exclusion Criteria:

* Has any prior history of cancer other than SGT
* Has any MRI contra-indications
* Has a history of known renal disease.
* Has history of prior radiation to head and neck region
* Is pregnant

Where it's running

  • Hospital of the University of Pennsylvania
    Philadelphia, Pennsylvania, United States
    Recruiting

Study contacts

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How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.