Using advanced MRI to differentiate between cancerous and non-cancerous salivary gland tumors
Official title: Physiologic MR Imaging in Distinguishing Benign From Malignant Salivary Gland Tumors
Run by Abramson Cancer Center at Penn Medicine · NCT04452162 · Data updated 2026-11-12
This study is testing if advanced MRI can help doctors tell the difference between cancerous and non-cancerous salivary gland tumors in patients who haven't started treatment yet.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 30 (estimated) |
| Sponsor | Abramson Cancer Center at Penn Medicine Academic / other |
| Drugs / interventions | radiation |
| Locations | 1 site (Philadelphia, Pennsylvania) |
| Status | Recruiting |
| Started | August 25, 2020 |
| Main results expected | June 2026 |
| Study ends | June 2026 |
| Registry record updated | September 9, 2025 |
| Trial ID | NCT04452162 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are individuals with a salivary gland lesion of at least 1cm3 who have not received prior treatment for their condition.
✕Probably not a fit
Patients with a history of other cancers, MRI contraindications, renal disease, prior radiation to the head and neck, or who are pregnant may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study aims to utilize advanced Magnetic Resonance Imaging (MRI) techniques to distinguish between benign and malignant salivary gland tumors. A total of 30 treatment-naïve patients with suspected salivary gland tumors will undergo a comprehensive MRI protocol that includes both anatomical imaging and dynamic contrast-enhanced imaging. The study will analyze specific imaging parameters to improve treatment strategies and predict disease progression based on the tumor's characteristics.
Why it matters
Potential benefit: If successful, this study could lead to more accurate diagnoses and tailored treatment plans for patients with salivary gland tumors.
How similar studies have gone: While the approach of using advanced MRI techniques is promising, it is relatively novel and has not been extensively tested in similar studies.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Possess a salivary gland lesion of 1cm3 size * Have no prior history of treatment for salivary gland lesion Exclusion Criteria: * Has any prior history of cancer other than SGT * Has any MRI contra-indications * Has a history of known renal disease. * Has history of prior radiation to head and neck region * Is pregnant
Where it's running
-
Hospital of the University of Pennsylvania
Philadelphia, Pennsylvania, United States Recruiting
Study contacts
- Principal investigator: Sanjeev Chawla — Professor
- Study coordinator: Marisa Sanchez
- Email: Marisa.Sanchez@pennmedicine.upenn.edu
- Phone: 2159019994
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.