Low Dose Radiotherapy for Osteoarthritis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a single-arm prospective study conducted at a single institution across multiple sites to evaluate the effects of low-dose radiotherapy on pain and function in osteoarthritis. Participants will complete patient-reported outcome measures to track changes in pain, function, and well-being after treatment. Instruments used include BPI-SF, LEFS, UEFI, and PROMIS Global to capture patient-centered outcomes. The study focuses on individuals who are refractory to standard therapies or are being considered for more aggressive interventions but prefer less invasive options. Results will inform whether LDRT is a feasible option for symptom relief in OA.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* 18 years or older
* Diagnosis of OA \>3 months in hips, knees, hands, shoulders, ankles or elbows.
* Refractory to standard of care therapies for OA or those who are being considered for more aggressive interventional treatment such as joint replacement, but more conservative treatment is desired.
* Provision of signed and dated informed consent.

Exclusion Criteria:

* Unable to reasonably complete study instruments.

Where it's running

• Penn Presbyterian Medical Center
  Philadelphia, Pennsylvania, United States Recruiting
• Perelman Center for Advanced Medicine
  Philadelphia, Pennsylvania, United States Recruiting

Study contacts

• Study coordinator: Marlowe Estioko, BS, MS
• Email: Marlowe.Estioko@Pennmedicine.upenn.edu
• Phone: 267-343-6483

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.