Using a special imaging technique to evaluate breast cancer

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study involves patients with known or suspected breast cancer who have at least one lesion measuring 1.5 cm or larger. Participants will undergo PET/CT imaging with a novel tracer, [18F]F-GLN, to assess its uptake and image quality. The study aims to stratify patients based on breast cancer subtypes, specifically focusing on estrogen-receptor-expressing and triple-negative breast cancers. The results will not directly influence treatment decisions but will provide valuable data on the imaging technique's effectiveness.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Participants will be ≥ 18 years of age
* Known or suspected primary or metastatic breast cancer.
* At least one lesion ≥ 1.0 cm that is seen on standard imaging (e.g. CT, MRI, mammogram, ultrasound, FDG-PET/CT). Only one type of imaging is required to show a lesion.
* Participants must be informed of the investigational nature of this study and be willing to provide written informed consent and participate in this study in accordance with institutional and federal guidelines prior to study-specific procedures.

Exclusion Criteria:

* Females who are pregnant or breast feeding at the time of screening; a urine pregnancy test will be performed in women of child-bearing potential at screening.
* Inability to tolerate imaging procedures in the opinion of an investigator or treating physician.
* Any current medical condition, illness, or disorder, as assessed by medical record review and/or self-reported, that is considered by a physician investigator to be a condition that could compromise participant safety or successful participation in the study.

Where it's running

• University of Pennsylvania
  Philadelphia, Pennsylvania, United States Recruiting

Study contacts

• Principal investigator: Austin Pantel, MD — Instructor of Radiology
• Study coordinator: Erin Schubert
• Email: erin.schubert@pennmedicine.upenn.edu
• Phone: 215-573-6569

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.