Clinical trial Recruiting at 1 site Observational Ages 18 and up Women only

Examining the immune environment in different types of breast cancer

Official title: Role of the Immune Environment in Response to Therapy in Breast Cancer

Run by Abramson Cancer Center at Penn Medicine · NCT05396612 · Data updated 2026-11-12

This study looks at tissue samples from women with different types of breast cancer to see how the immune environment affects treatment responses.

More Breast Cancer trials

Quick facts

Study typeObservational
Ages18 Years and up
SexWomen only
Enrollment300 (estimated)
SponsorAbramson Cancer Center at Penn Medicine
Academic / other
Locations1 site (Philadelphia, Pennsylvania)
StatusRecruiting
StartedOctober 3, 2022
Main results expectedDecember 31, 2032
Study endsDecember 31, 2032
Registry record updatedJuly 8, 2025
Trial IDNCT05396612 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are women aged 18 and older with non-metastatic breast cancer who are undergoing surgical resection at the University of Pennsylvania Health System.

Probably not a fit

Patients who are male, children, or pregnant individuals will not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study analyzes tissue samples from women with various types of breast cancer, specifically focusing on the immune environments of ER+HER2- breast cancers compared to triple-negative and HER2+ breast cancers. The study does not involve any randomization or changes to standard treatment protocols, and it collects personal health information from participants under a HIPAA waiver. The goal is to better understand how the immune environment influences therapy responses in these breast cancer subtypes.

Why it matters

Potential benefit: If successful, this study could lead to improved treatment strategies tailored to the immune profiles of different breast cancer types.

How similar studies have gone: Other studies have explored the immune environment in breast cancer, showing promising results, but this specific approach is relatively novel.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion criteria:

Women 18 years of age or older with non-metastatic breast cancer undergoing surgical resection in the University of Pennsylvania Health System.

Exclusion criteria:

Males Children Pregnant individuals

Where it's running

  • Abramson Cancer Center
    Philadelphia, Pennsylvania, United States
    Recruiting

Study contacts

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How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.