Examining the immune environment in different types of breast cancer
Official title: Role of the Immune Environment in Response to Therapy in Breast Cancer
Run by Abramson Cancer Center at Penn Medicine · NCT05396612 · Data updated 2026-11-12
This study looks at tissue samples from women with different types of breast cancer to see how the immune environment affects treatment responses.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | Women only |
| Enrollment | 300 (estimated) |
| Sponsor | Abramson Cancer Center at Penn Medicine Academic / other |
| Locations | 1 site (Philadelphia, Pennsylvania) |
| Status | Recruiting |
| Started | October 3, 2022 |
| Main results expected | December 31, 2032 |
| Study ends | December 31, 2032 |
| Registry record updated | July 8, 2025 |
| Trial ID | NCT05396612 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are women aged 18 and older with non-metastatic breast cancer who are undergoing surgical resection at the University of Pennsylvania Health System.
✕Probably not a fit
Patients who are male, children, or pregnant individuals will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study analyzes tissue samples from women with various types of breast cancer, specifically focusing on the immune environments of ER+HER2- breast cancers compared to triple-negative and HER2+ breast cancers. The study does not involve any randomization or changes to standard treatment protocols, and it collects personal health information from participants under a HIPAA waiver. The goal is to better understand how the immune environment influences therapy responses in these breast cancer subtypes.
Why it matters
Potential benefit: If successful, this study could lead to improved treatment strategies tailored to the immune profiles of different breast cancer types.
How similar studies have gone: Other studies have explored the immune environment in breast cancer, showing promising results, but this specific approach is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion criteria: Women 18 years of age or older with non-metastatic breast cancer undergoing surgical resection in the University of Pennsylvania Health System. Exclusion criteria: Males Children Pregnant individuals
Where it's running
-
Abramson Cancer Center
Philadelphia, Pennsylvania, United States Recruiting
Study contacts
- Principal investigator: Jennifer Zhang, MD — Abramson Cancer Center
- Study coordinator: Julia T. Lewandowski
- Email: Julia.Lewandowski@Pennmedicine.upenn.edu
- Phone: 215-662-2861
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.