Lifestyle and energy balance in breast cancer survivorship
Official title: The MILES Study: A Mixed-Methods Metabolomics Investigation of Lifestyle and Energy Balance During Breast Cancer Survivorship
Run by Abramson Cancer Center at Penn Medicine · NCT07655934 · Data updated 2026-11-12
This study tests how diet, physical activity, and urinary metabolites relate to lifestyle changes in women newly diagnosed with breast cancer during treatment and survivorship.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | Women only |
| Enrollment | 100 (estimated) |
| Sponsor | Abramson Cancer Center at Penn Medicine Academic / other |
| Locations | 1 site (Philadelphia, Pennsylvania) |
| Status | Recruiting |
| Started | January 20, 2026 |
| Main results expected | December 2028 |
| Study ends | December 2028 |
| Registry record updated | June 24, 2026 |
| Trial ID | NCT07655934 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adult women (18+) with newly diagnosed primary breast cancer (stages 0–III), able to read English or Spanish, and scheduled for surgery with a Penn Medicine surgeon.
✕Probably not a fit
Patients who do not adopt or sustain lifestyle changes may not experience measurable benefits from the project.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
The study uses a longitudinal mixed-methods design with quantitative surveys and urine metabolomics to track dietary quality, activity, and other factors at three time points around surgery. A subset of participants will participate in semi-structured interviews to explore barriers, facilitators, and financial hardship influencing healthy lifestyle adoption. Urine samples collected on the same day as surveys will be analyzed with NMR spectroscopy and linked to the lifestyle data. The research aims to identify scalable tools to support patients in improving and maintaining healthy behaviors through treatment and survivorship. The study is conducted at Penn Medicine with collaboration from Penn State, enrolling up to 100 participants for surveys and urine samples, and 50 for interviews.
Why it matters
Potential benefit: If successful, the study could provide actionable insights and tools to help patients adopt and sustain healthier lifestyles during breast cancer treatment.
How similar studies have gone: Previous work in lifestyle and biomarker research in cancer populations has shown meaningful associations between behavior change and biological measures, but this exact mixed-methods approach in early breast cancer is innovative.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adult women (age 18 years or older) * Able to read English or Spanish * Newly diagnosed with primary stage 0, I, II, or III breast cancer * Pathological diagnosis within the previous 60 days * Scheduled to have surgery with a Penn Medicine surgeon Exclusion Criteria: * Women age less than 18 years * Women without a new primary breast cancer diagnosis * Women who are pregnant
Where it's running
-
Abamson Cancer Center of the University of Pennsylvania
Philadelphia, Pennsylvania, United States Recruiting
Study contacts
- Study coordinator: Julia Lewandowski
- Email: Julia.lewandowski@pennmedicine.upenn.edu
- Phone: 215-913-2031
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.