Safe and explainable AI to help doctors with heart disease, sepsis, and breast cancer care

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Researchers will develop and validate AI-powered clinical decision support systems using electronic health record data and the Penn Cancer Registry from 2017 onward. The work focuses on integrating medical knowledge into models, making recommendations explainable to clinicians, and building safety guarantees for real-world use. The effort is observational and uses retrospective and prospective data from adult cardiology admissions, sepsis presentations, and invasive breast cancer cases, excluding pediatric patients and certain clinical subgroups (for example cardiac arrest primaries and patients with pre-existing limits on life-sustaining therapy). Models will be tested for predictive performance, transparency of their outputs, and measures intended to reduce unsafe or misleading recommendations.

Why it matters

Who can join: the full rules

Inclusion Criteria:

Cardiology 18 years of age and older, admitted to any of the Penn Medicine hospitals from 2017 to the present. Sepsis 18 years of age at the time of presentation to an emergency department or admission to any Penn Medicine hospital from July 1, 2017, onward will be eligible as this represents the population at risk for acquiring sepsis Oncology 18 years of age and older with a diagnosis of invasive breast cancer (Stage 1-4) in the Penn Cancer registry

Exclusion Criteria All prediction models will exclude patients under the age of 18 from their patient data sets.

Cardiology Patients whose primary admission diagnosis was cardiac arrest Sepsis Those with pre-existing limitations on life-sustaining therapy will be excluded because their eligibility for sepsis definitions, care received, and outcomes, may be significantly and variably affected by pre-existing limitations on care. Oncology There are no other exclusions.

Where it's running

• Hospital of the University of Pennsylvania
  Philadelphia, Pennsylvania, United States Recruiting

Study contacts

• Study coordinator: Haideliza Soto Calderon
• Email: haideliza.soto-calderon@pennmedicine.upenn.edu
• Phone: 215-220-9425

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.