Understanding autoimmunity in cancer patients treated with immune checkpoint inhibitors

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to investigate how cancer treatment with immune checkpoint inhibitors can lead to the development of autoimmunity in some patients. It will enroll at least 300 cancer patients who are prescribed these therapies and collect peripheral blood, serum, and urine samples at various time points, including when autoimmune symptoms arise. The study will analyze genetic and immune system features to identify factors associated with immune-related adverse events. There will be no interventions, and clinical data will be gathered from electronic medical records.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* A diagnosis of cancer and prescription for a checkpoint inhibitor

Exclusion Criteria:

* Any subjects not willing or able to give consent
* Children under the age of 18
* A history of transplant

Where it's running

• University of Pennsylvania - Abramson Cancer Center
  Philadelphia, Pennsylvania, United States Recruiting

Study contacts

• Principal investigator: Sokratis Apostolidis, MD — University of Pennsylvania
• Study coordinator: Kyra J Sacksith
• Email: kyra.sacksith@pennmedicine.upenn.edu
• Phone: 215-898-9339

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.