Drug or treatment

Vedolizumab clinical trials

• 25Clinical trials
• 39Countries

Newest trials

All recruiting trials (25)

• Upadacitinib with or without vedolizumab for induction in moderate-to-severe ulcerative colitis

  This study tests whether adding vedolizumab to upadacitinib helps adults with moderate-to-severe ulcerative colitis achieve better short-term (8-week) control than upadacitinib alone.

  Recruiting at 6 sites Sixth Affiliated Hospital, Sun Yat-sen University · Foshan, Guangdong and 5 other locations · NCT07442045

• Using intestinal ultrasound to predict vedolizumab response and transmural healing in early Crohn's disease

  This project will test if intestinal ultrasound can predict how well vedolizumab works and show transmural healing in adults with early Crohn's disease.

  Recruiting The Third Xiangya Hospital of Central South University · Changsha, Hunan · NCT07093294

• OD-07656 followed by vedolizumab for moderate to severe ulcerative colitis

  This test tries OD-07656, followed by vedolizumab, to see if it improves symptoms in people with moderate to severe ulcerative colitis who have not responded well to other treatments.

  Recruiting at 32 sites Phase 2 Odyssey Therapeutics, Inc. · Birtinya and 31 other locations · NCT06850727

• Early vedolizumab as first-line treatment for immune-related colitis

  We will test whether giving vedolizumab with a short steroid course helps adults with immune checkpoint inhibitor–related colitis recover by 8 weeks better than the usual steroid approach.

  Recruiting at 2 sites Phase 2 Brigham and Women's Hospital · Boston, Massachusetts and 1 other locations · NCT06841705

• Vedolizumab with post-transplant cyclophosphamide and short-course tacrolimus to prevent graft-versus-host disease after reduced-intensity allogeneic stem cell transplant

  This trial tests whether adding vedolizumab to post-transplant cyclophosphamide and a short course of tacrolimus can prevent graft-versus-host disease in adults getting reduced-intensity allogeneic stem cell transplants for leukemias or related blood disorders.

  Recruiting Phase 2 City of Hope Medical Center · Duarte, California · NCT06815003

• Preventing GVHD in children and young adults with blood cancers

  This study is testing a new treatment plan to see if it can help prevent graft-versus-host disease in children and young adults with blood cancers after they receive a transplant.

  Recruiting Phase 2/3 Federal Research Institute of Pediatric Hematology, Oncology and Immunology · Moscow · NCT06756152

• Comparing subcutaneous and intravenous vedolizumab for inflammatory bowel disease with remote monitoring

  This study is testing if a digital health system can help people with inflammatory bowel disease stick to their vedolizumab treatment, whether they receive it through an injection under the skin or through an IV, and how it affects their health over 22 weeks.

  Recruiting at 2 sites Mercy Medical Center · New Orleans, Louisiana and 5 other locations · NCT06750731

• Comparing target therapies for ulcerative colitis after anti-TNFα treatment

  This study is testing how well three different treatments work for adults with ulcerative colitis who haven't improved after their first anti-TNF-alpha therapy.

  Recruiting Humanitas Clinical and Research Center · Mialn, Italy · NCT06691061

• Combining Probiotic VSL#3 with Vedolizumab for Moderate Ulcerative Colitis

  This study is testing if adding a probiotic called VSL#3 to the medication Vedolizumab can help adults with moderate ulcerative colitis feel better.

  Recruiting at 3 sites Phase 4 Second Affiliated Hospital, Zhejiang University, School of Medicine · Beijing, Beijing Municipality and 11 other locations · NCT06609447

• Treatment of Ulcerative Colitis and Crohn's Disease with Vedolizumab

  This study is testing if a new medication called Vedolizumab can help adults with Ulcerative Colitis or Crohn's Disease feel better and stay symptom-free over a year.

  Recruiting at 78 sites Phase 4 Takeda · Birmingham, Alabama and 100 other locations · NCT06581328

• Evaluating the safety and effectiveness of vedolizumab in children and teenagers with chronic pouchitis

  This study is testing if a medication called vedolizumab can help children and teenagers with chronic pouchitis feel better and stay healthy after bowel surgery.

  Recruiting at 14 sites Phase 3 Takeda · Leuven, Vlaams-Brabant and 13 other locations · NCT06443502

• Long-term vedolizumab treatment for children and teenagers with ulcerative colitis or Crohn's disease

  This extension tests whether continuing subcutaneous vedolizumab is safe and helps children and teenagers with moderate to severe ulcerative colitis or Crohn's disease stay well.

  Recruiting at 12 sites Phase 3 Takeda · Phoenix, Arizona and 46 other locations · NCT06405087

• Vedolizumab to prevent ICI-related diarrhea or colitis in cancer patients

  This study tests whether vedolizumab can prevent immune checkpoint inhibitor–related diarrhea or colitis in adults with unresectable or metastatic melanoma, lung, or kidney cancer starting immunotherapy.

  Recruiting Phase 2/3 AHS Cancer Control Alberta · Calgary, Alberta and 1 other locations · NCT06337695

• Combining vedolizumab and upadacitinib for treating Crohn's Disease

  This study is testing if combining two medications, vedolizumab and upadacitinib, can help adults with moderate to severe Crohn's Disease feel better compared to using vedolizumab alone.

  Recruiting at 8 sites Phase 3 Takeda · La Jolla, California and 137 other locations · NCT06227910

• Comparing Vedolizumab and Adalimumab for Crohn's Disease Treatment

  This study is testing whether switching to Vedolizumab or increasing the dose of Adalimumab works better for people with Crohn's disease who aren't responding to their current Adalimumab treatment.

  Recruiting at 12 sites Phase 4 Centre Hospitalier Universitaire de Saint Etienne · Le Kremlin-Bicêtre, PARIS and 11 other locations · NCT06180382

• Vedolizumab treatment for children and teenagers with ulcerative colitis or Crohn's disease

  This study is testing how well the drug vedolizumab works for children and teenagers with ulcerative colitis or Crohn's disease when given through injections after an initial dose through an IV.

  Recruiting at 26 sites Phase 3 Takeda · Phoenix, Arizona and 53 other locations · NCT06100289

• Combining Vedolizumab and Upadacitinib for Ulcerative Colitis Treatment

  This study is testing if combining two medications, Vedolizumab and Upadacitinib, can help people with moderate to severe ulcerative colitis feel better faster and stay well longer.

  Recruiting Sixth Affiliated Hospital, Sun Yat-sen University · Guangzhou, Guangdong · NCT06095596

• Evaluating Vedolizumab for treating moderate to severe Crohn's Disease in adults

  This study is testing if an intravenous medication called vedolizumab can help adults in China with moderate to severe Crohn's Disease feel better over 58 weeks.

  Recruiting at 33 sites Phase 3 Takeda · Hefei, Anhui and 42 other locations · NCT05837897

• Vedolizumab effects on gut microbes and symptom improvement in ulcerative colitis

  This study will test whether vedolizumab changes gut microbes and metabolites and helps adults with moderate to severe ulcerative colitis.

  Recruiting Phase 4 Second Affiliated Hospital, Zhejiang University, School of Medicine · Zhengzhou, Hangzhou · NCT05481619

• Vedolizumab treatment for children with ulcerative colitis or Crohn's disease

  This study is testing how safe the medication vedolizumab is for children with ulcerative colitis or Crohn's disease who have already tried it before.

  Recruiting at 44 sites Phase 3 Takeda · Mobile, Alabama and 97 other locations · NCT05442567

• Observing the effects of vedolizumab in adults with ulcerative colitis or Crohn's disease in South Korea

  This study is looking at how well the medication vedolizumab works for adults in South Korea with moderate to severe ulcerative colitis or Crohn's disease who haven't had success with other treatments.

  Recruiting Takeda · Goyang-si, Gyeonggi-do · NCT05428345

• Comparing LFMT and placebo for treating ulcerative colitis

  This study is testing whether a new treatment made from processed stool can help people with active ulcerative colitis feel better when they start taking certain medications.

  Recruiting Phase 2 University of Alberta · Edmonton, Alberta · NCT05327790

• Treatment of moderate to severe Crohn's disease in children and teenagers with vedolizumab

  This study is testing if a new medication called vedolizumab can help children and teenagers with moderate to severe Crohn's disease feel better and reduce inflammation in their digestive system.

  Recruiting at 29 sites Phase 3 Takeda · Phoenix, Arizona and 95 other locations · NCT04779320

• Effects of Ulcerative Colitis Treatments on Heart Health

  This study is testing how different treatments for ulcerative colitis might affect heart health over time.

  Recruiting Phase 4 Centre Hospitalier Universitaire, Amiens · Amiens · NCT04743518

• High dose vitamin D for young patients with inflammatory bowel disease on biologic therapy

  This study is testing if giving high doses of vitamin D to young people with inflammatory bowel disease who are on biologic treatments can improve their bone health and reduce inflammation.

  Recruiting Boston Children's Hospital · Boston, Massachusetts · NCT04331639

Quick answers

How many clinical trials of Vedolizumab are recruiting right now?

25, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 39 countries. The most sites are in United States (10 trials), China (8 trials), Italy (7 trials), Poland (7 trials), Canada (6 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 3: 7, Phase 4: 5, Phase 2: 4, Phase 2/3: 2. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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