AI-based imaging score for assessing ulcerative colitis
Official title: A Novel Simplified Endoscopic Score aiMed at Evaluating Ulcerative cOlitis Activity Through TXI, RDI and NBI Vascular Assessment and at prEdicting Clinical Outcome and Its Applicability in an arTificial Intelligence System: the MONET Study
Run by University College Cork · NCT06709209 · Data updated 2026-11-12
This study is testing a new scoring system using advanced imaging techniques to see if it can better assess the condition of the colon in people with ulcerative colitis compared to current methods.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years to 75 Years |
| Sex | All |
| Enrollment | 300 (estimated) |
| Sponsor | University College Cork Academic / other |
| Locations | 11 sites (Leuven and 10 other locations) |
| Status | Recruiting |
| Started | November 4, 2024 |
| Main results expected | September 30, 2026 |
| Study ends | September 30, 2027 |
| Registry record updated | December 3, 2024 |
| Trial ID | NCT06709209 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include adults aged 18 to 75 with a confirmed diagnosis of ulcerative colitis who are undergoing endoscopy for disease assessment.
✕Probably not a fit
Patients with contraindications to endoscopy or significant comorbidities that limit life expectancy may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This international multicentre study aims to create a new scoring system using advanced endoscopic techniques to evaluate the vascular features of the colon in patients with ulcerative colitis (UC). The study will develop this score by analyzing virtual electronic chromoendoscopy videos and comparing its effectiveness in determining disease activity and remission against existing scores. Additionally, it will adapt artificial intelligence algorithms to enhance the standardization of disease assessment and predict long-term outcomes for UC patients. The study will involve expert reviews and discussions to refine the scoring criteria.
Why it matters
Potential benefit: If successful, this study could lead to more accurate assessments of ulcerative colitis, improving patient management and outcomes.
How similar studies have gone: Other studies have shown promise in using advanced imaging techniques and AI for disease assessment, indicating potential success for this approach.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adult patients aged 18 to 75 years old * Established diagnosis of UC (for at least six months in duration), independently from their active treatment * Undergoing endoscopy for disease activity assessment or cancer surveillance. Exclusion Criteria: * Contraindications to endoscopy (including toxic megacolon) and biopsies (including severe coagulopathy/thrombocytopenia) * Poor bowel preparation (defined as total BBPS \<6 or BBPS \<2 in observed segment for sigmoidoscopy) * Significant co-morbidities limiting life expectancy and conferring high risk of endoscopy * Pregnant and breast-feeding subjects * Inability to provide informed consent * If the participant has been in a recent experimental trial, these must have been completed not less than thirty days prior to this study
Where it's running
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University College Cork
Cork, Co Cork, Ireland Recruiting -
University of Naples
Naples, Italy Recruiting -
University of Leuven
Leuven, Belgium Not yet recruiting -
Klinikum Luneburg
Lüneburg, Germany Not yet recruiting -
Ospedale S. Maria del Prato
Feltre, Belluno, Italy Not yet recruiting -
University of Bari
Bari, Italy Not yet recruiting
Show 5 more locations
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Istituto Clinico Humanitas
Milan, Italy Not yet recruiting -
University Vita-Salute San Raffaele
Milan, Italy Not yet recruiting -
University of Pavia
Pavia, Italy Not yet recruiting -
Showa University
Tokyo, Japan Not yet recruiting -
Changi General Hospital
Singapore, Singapore Not yet recruiting
Study contacts
- Principal investigator: Marietta Iacucci, MD — University College Cork
- Study coordinator: Michelle O'Riordan
- Email: moriordan@ucc.ie
- Phone: +353 (0)21 4901759
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
MGT-006 safety and dosing study for ulcerative colitis
This study tests an oral microbiome capsule called MGT-006 to see if it is safe and tolerable in adults with moderately active ulcerative colitis, and whether the gut bacteria engraft after treatment.
-
PALI-2108 vs placebo for moderate to severe ulcerative colitis
A phase 2 study to see if PALI-2108 helps people with moderate to severe ulcerative colitis more than a placebo.
-
Nitazoxanide as an add-on therapy for mild-to-moderate ulcerative colitis
A study tests whether adding nitazoxanide to standard UC treatment helps people with mild-to-moderate ulcerative colitis see more relief.
-
Fecal Transplants from Dai vs Han Donors for Ulcerative Colitis
This study tests whether fecal microbiota transplantation from healthy Dai donors improves symptoms in adults with ulcerative colitis more than transplantation from healthy Han donors.
-
Familial IBD Early Risk
This study tests whether clinical, environmental, and immune factors in first-degree relatives of people with Crohn’s disease or ulcerative colitis can predict who will develop IBD.
-
Probiotics and Trace Elements Added to Infliximab in Ulcerative Colitis
This trial tests whether adding a Lactobacillus probiotic or trace elements to infliximab helps people with ulcerative colitis stay in remission.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.