How a patient's blood reacts during transcatheter aortic valve replacement (TAVR)
Official title: Patient-specific blood cell reactivity and flow dynamic profiles in transcatheter aortic valve replacement
Funded at Oregon Health & Science University · NIH-11251596 · Data updated 2026-11-12
This project looks at how individual patients' blood cells and blood flow change during TAVR to help reduce clotting and inflammation for people getting minimally invasive aortic valve replacements.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oregon Health & Science University NIH-funded |
| Lab location | 1 site (Portland, United States) |
| Project start | December 20, 2023 |
| Project end | November 30, 2027 |
| Funding year | 2026 |
| Award (this year) | $661,173 |
| NIH project number | 5R01HL167442-03 |
| Project ID | NIH-11251596 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal participants are adults scheduled to undergo TAVR for aortic valve disease who can provide blood samples and clinical information.
✕Less likely to help
People who are not having TAVR, have unrelated heart conditions, or cannot provide blood samples or follow-up data are unlikely to benefit directly.
What this research studies
If you join, researchers will collect blood samples and clinical data before and after your TAVR procedure to measure platelet activation and other clotting or inflammatory signals. They will use imaging and patient-specific blood-flow models and lab tests that mimic valve conditions to see how valve placement and device materials change shear forces and promote procoagulant platelets. The team combines lab assays, fluid dynamics modeling, and comparisons across patients to identify who is at higher risk for subclinical leaflet thrombosis or valve degeneration. Results could guide more personalized choices about anticoagulant or antiplatelet treatment after TAVR.
Why it matters
Potential benefit: If successful, this could help personalize blood-clot prevention and reduce inflammatory complications after TAVR.
How similar studies have gone: Prior studies have documented platelet activation and subclinical leaflet thrombosis after TAVR, but combining patient blood profiling with individualized flow modeling is a relatively new approach.
Where this research is happening
-
Oregon Health & Science University
Portland, United States Active
Researchers
- Principal investigator: Hinds, Monica T — Oregon Health & Science University
- Study coordinator: Hinds, Monica T
Related research
Other NIH-funded projects on the same topics.
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Rehabbing with Peloton: a heart-healthy fitness program on a popular app for people after TAVR
A patient-friendly program uses a commercial fitness app to help people recovering from transcatheter aortic valve replacement improve daily activity and physical fitness.
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Home Peloton cardiac rehab for people recovering from TAVR
This project offers an 8-week Peloton-based at-home exercise program to help people become more active and recover after transcatheter aortic valve replacement (TAVR).
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Investigating how platelets and blood factors affect inflammation after heart valve replacement
This study is looking at how blood platelets and other factors affect recovery after a heart procedure called TAVR, which helps people with a narrowed aortic valve, and it aims to find ways to make the procedure safer and more effective for patients who can't have regular surgery.
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How blood cell activity changes during aortic valve replacement
This study is looking at how differences in your blood cells can impact your recovery after getting a new heart valve through a procedure called TAVR, with the hope of finding ways to make your experience better and reduce complications.
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Improving outcomes for patients undergoing aortic valve replacement
This study looks at what helps some patients with aortic stenosis do better after getting a new heart valve through a procedure called TAVR, so we can find ways to improve care and reduce complications for everyone who has this treatment.
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Using Peloton for cardiac rehabilitation after heart valve surgery
This study is looking at how using the Peloton fitness app can help people recovering from heart valve surgery get more active and stay healthy, making it easier for them to join in on their rehab from home.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.