How a patient's blood reacts during transcatheter aortic valve replacement (TAVR)
Patient-specific blood cell reactivity and flow dynamic profiles in transcatheter aortic valve replacement
['FUNDING_R01'] · OREGON HEALTH & SCIENCE UNIVERSITY · NIH-11251596
This project looks at how individual patients' blood cells and blood flow change during TAVR to help reduce clotting and inflammation for people getting minimally invasive aortic valve replacements.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | OREGON HEALTH & SCIENCE UNIVERSITY (nih funded) |
| Locations | 1 site (PORTLAND, UNITED STATES) |
| Trial ID | NIH-11251596 on ClinicalTrials.gov |
What this research studies
If you join, researchers will collect blood samples and clinical data before and after your TAVR procedure to measure platelet activation and other clotting or inflammatory signals. They will use imaging and patient-specific blood-flow models and lab tests that mimic valve conditions to see how valve placement and device materials change shear forces and promote procoagulant platelets. The team combines lab assays, fluid dynamics modeling, and comparisons across patients to identify who is at higher risk for subclinical leaflet thrombosis or valve degeneration. Results could guide more personalized choices about anticoagulant or antiplatelet treatment after TAVR.
Who could benefit from this research
Good fit: Ideal participants are adults scheduled to undergo TAVR for aortic valve disease who can provide blood samples and clinical information.
Not a fit: People who are not having TAVR, have unrelated heart conditions, or cannot provide blood samples or follow-up data are unlikely to benefit directly.
Why it matters
Potential benefit: If successful, this could help personalize blood-clot prevention and reduce inflammatory complications after TAVR.
How similar studies have performed: Prior studies have documented platelet activation and subclinical leaflet thrombosis after TAVR, but combining patient blood profiling with individualized flow modeling is a relatively new approach.
Where this research is happening
PORTLAND, UNITED STATES
- OREGON HEALTH & SCIENCE UNIVERSITY — PORTLAND, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: HINDS, MONICA T — OREGON HEALTH & SCIENCE UNIVERSITY
- Study coordinator: HINDS, MONICA T
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Aortic valvular disorders