How blood cell activity changes during aortic valve replacement
Official title: Patient-specific blood cell reactivity and flow dynamic profiles in transcatheter aortic valve replacement
Funded at Oregon Health & Science University · NIH-11002674 · Data updated 2026-11-12
This study is looking at how differences in your blood cells can impact your recovery after getting a new heart valve through a procedure called TAVR, with the hope of finding ways to make your experience better and reduce complications.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oregon Health & Science University NIH-funded |
| Lab location | 1 site (Portland, United States) |
| Project start | December 20, 2023 |
| Project end | November 30, 2027 |
| Funding year | 2025 |
| Award (this year) | $608,332 |
| NIH project number | 5R01HL167442-02 |
| Project ID | NIH-11002674 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with aortic valve diseases who are scheduled for transcatheter aortic valve replacement.
✕Less likely to help
Patients who are not undergoing TAVR or have other unrelated cardiovascular conditions may not benefit from this research.
What this research studies
This research investigates how individual differences in blood cell behavior affect outcomes in patients undergoing transcatheter aortic valve replacement (TAVR). By analyzing patient-specific factors such as blood flow dynamics and biochemical responses, the study aims to understand how these variations contribute to complications like inflammation and clotting. The research employs advanced experimental techniques to explore the relationship between these factors and the performance of artificial heart valves. Ultimately, the goal is to improve patient management and outcomes in those with aortic valve diseases.
Why it matters
Potential benefit: If successful, this research could lead to better management strategies for patients undergoing aortic valve replacement, reducing complications and improving recovery.
How similar studies have gone: Previous research has shown promising results in understanding blood cell dynamics in cardiovascular procedures, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Oregon Health & Science University
Portland, United States Active
Researchers
- Principal investigator: Hinds, Monica T — Oregon Health & Science University
- Study coordinator: Hinds, Monica T
Related research
Other NIH-funded projects on the same topics.
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Rehabbing with Peloton: a heart-healthy fitness program on a popular app for people after TAVR
A patient-friendly program uses a commercial fitness app to help people recovering from transcatheter aortic valve replacement improve daily activity and physical fitness.
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Home Peloton cardiac rehab for people recovering from TAVR
This project offers an 8-week Peloton-based at-home exercise program to help people become more active and recover after transcatheter aortic valve replacement (TAVR).
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How a patient's blood reacts during transcatheter aortic valve replacement (TAVR)
This project looks at how individual patients' blood cells and blood flow change during TAVR to help reduce clotting and inflammation for people getting minimally invasive aortic valve replacements.
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Investigating how platelets and blood factors affect inflammation after heart valve replacement
This study is looking at how blood platelets and other factors affect recovery after a heart procedure called TAVR, which helps people with a narrowed aortic valve, and it aims to find ways to make the procedure safer and more effective for patients who can't have regular surgery.
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Improving outcomes for patients undergoing aortic valve replacement
This study looks at what helps some patients with aortic stenosis do better after getting a new heart valve through a procedure called TAVR, so we can find ways to improve care and reduce complications for everyone who has this treatment.
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Using Peloton for cardiac rehabilitation after heart valve surgery
This study is looking at how using the Peloton fitness app can help people recovering from heart valve surgery get more active and stay healthy, making it easier for them to join in on their rehab from home.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.