Improving outcomes for patients undergoing aortic valve replacement

Identifying Modifiable Practices Related to Outcome Variation and Enhancement in Transcatheter Aortic Valve Replacement (IMPROVE TAVR)

NIH-funded research Massachusetts General Hospital · NIH-11001174

This study looks at what helps some patients with aortic stenosis do better after getting a new heart valve through a procedure called TAVR, so we can find ways to improve care and reduce complications for everyone who has this treatment.

Quick facts

Grant typeNIH-funded research
Study typeNIH-funded research
Funding institutionMassachusetts General Hospital NIH-funded
Lab location1 site (Boston, United States)
Project IDNIH-11001174 on NIH RePORTER

What this research studies

This research investigates the factors that lead to differences in patient outcomes after transcatheter aortic valve replacement (TAVR), particularly focusing on patients with aortic stenosis. By analyzing data from various hospitals, the study aims to identify best practices and organizational processes that contribute to better results, such as lower rates of complications and readmissions. The research employs a mixed methods approach, combining quantitative data analysis with qualitative insights to understand what makes certain hospitals perform better than others. Ultimately, the goal is to enhance the care provided to patients undergoing this procedure.

Who could benefit from this research

Good fit: Ideal candidates for this research are elderly patients, particularly those over 75 years of age, who are diagnosed with symptomatic severe aortic stenosis and are considering TAVR.

Not a fit: Patients who are not candidates for TAVR or those with mild aortic stenosis may not benefit from this research.

Why it matters

Potential benefit: If successful, this research could lead to improved patient outcomes and reduced complications for those undergoing transcatheter aortic valve replacement.

How similar studies have performed: Previous research has shown that identifying best practices in healthcare can lead to significant improvements in patient outcomes, suggesting that this approach has potential for success.

Where this research is happening

Boston, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions acute kidney injury
Last reviewed 2026-06-09 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.