Improving outcomes for patients undergoing aortic valve replacement
Official title: Identifying Modifiable Practices Related to Outcome Variation and Enhancement in Transcatheter Aortic Valve Replacement (IMPROVE TAVR)
Funded at Massachusetts General Hospital · NIH-11001174 · Data updated 2026-11-12
This study looks at what helps some patients with aortic stenosis do better after getting a new heart valve through a procedure called TAVR, so we can find ways to improve care and reduce complications for everyone who has this treatment.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | January 21, 2022 |
| Project end | December 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $189,559 |
| NIH project number | 5K23HL157612-04 |
| Project ID | NIH-11001174 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are elderly patients, particularly those over 75 years of age, who are diagnosed with symptomatic severe aortic stenosis and are considering TAVR.
✕Less likely to help
Patients who are not candidates for TAVR or those with mild aortic stenosis may not benefit from this research.
What this research studies
This research investigates the factors that lead to differences in patient outcomes after transcatheter aortic valve replacement (TAVR), particularly focusing on patients with aortic stenosis. By analyzing data from various hospitals, the study aims to identify best practices and organizational processes that contribute to better results, such as lower rates of complications and readmissions. The research employs a mixed methods approach, combining quantitative data analysis with qualitative insights to understand what makes certain hospitals perform better than others. Ultimately, the goal is to enhance the care provided to patients undergoing this procedure.
Why it matters
Potential benefit: If successful, this research could lead to improved patient outcomes and reduced complications for those undergoing transcatheter aortic valve replacement.
How similar studies have gone: Previous research has shown that identifying best practices in healthcare can lead to significant improvements in patient outcomes, suggesting that this approach has potential for success.
Where this research is happening
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Massachusetts General Hospital
Boston, United States Active
Researchers
- Principal investigator: Kolte, Dhaval Sanjeev — Massachusetts General Hospital
- Study coordinator: Kolte, Dhaval Sanjeev
Related research
Other NIH-funded projects on the same topics.
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Rehabbing with Peloton: a heart-healthy fitness program on a popular app for people after TAVR
A patient-friendly program uses a commercial fitness app to help people recovering from transcatheter aortic valve replacement improve daily activity and physical fitness.
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Home Peloton cardiac rehab for people recovering from TAVR
This project offers an 8-week Peloton-based at-home exercise program to help people become more active and recover after transcatheter aortic valve replacement (TAVR).
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How a patient's blood reacts during transcatheter aortic valve replacement (TAVR)
This project looks at how individual patients' blood cells and blood flow change during TAVR to help reduce clotting and inflammation for people getting minimally invasive aortic valve replacements.
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Investigating how platelets and blood factors affect inflammation after heart valve replacement
This study is looking at how blood platelets and other factors affect recovery after a heart procedure called TAVR, which helps people with a narrowed aortic valve, and it aims to find ways to make the procedure safer and more effective for patients who can't have regular surgery.
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How blood cell activity changes during aortic valve replacement
This study is looking at how differences in your blood cells can impact your recovery after getting a new heart valve through a procedure called TAVR, with the hope of finding ways to make your experience better and reduce complications.
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Using Peloton for cardiac rehabilitation after heart valve surgery
This study is looking at how using the Peloton fitness app can help people recovering from heart valve surgery get more active and stay healthy, making it easier for them to join in on their rehab from home.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.