Using low contrast CT for planning heart valve replacement
Dual Energy CT Decreased IV Contrast Dose Imaging for TAVR
This study is testing if using less contrast dye in special CT scans can help doctors plan heart valve replacement surgery while keeping patients safer and saving money.
Quick facts
| Phase | Phase 4 |
|---|---|
| Study type | Interventional |
| Enrollment | 164 (estimated) |
| Ages | 18 Years to 88 Years |
| Sex | All |
| Sponsor | University of Maryland, Baltimore Academic / other |
| Locations | 1 site (Baltimore, Maryland) |
| Trial ID | NCT05758701 on ClinicalTrials.gov |
What this trial studies
This study investigates the use of low-dose iodinated contrast in dual energy CT scans for patients scheduled to undergo transcatheter aortic valve replacement (TAVR). The aim is to determine if this method can effectively assist in presurgical planning while reducing the risk of acute kidney injury and addressing the shortage of iodinated contrast agents. By utilizing monoenergetic reconstruction techniques, the study seeks to optimize imaging quality with a lower volume of contrast. This approach could lead to significant cost savings for healthcare facilities and improve patient safety.
Who should consider this trial
Good fit: Ideal candidates are patients scheduled to receive a TAVR abdominal CT.
Not a fit: Patients who cannot undergo a CT scan or have a GFR less than 30 will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could enhance the safety and efficiency of TAVR procedures by minimizing contrast-related complications.
How similar studies have performed: Other studies have explored low-dose contrast methods, but this specific approach using dual energy CT for TAVR planning is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * scheduled to receive TAVR abdominal CT Exclusion Criteria: * cannot undergo CT scan * Allergy to intravenous contrast not controlled by steroids or benadryl * GFR\<30
Where this trial is running
Baltimore, Maryland
- University of Maryland Medical Center — Baltimore, Maryland, United States (Recruiting)
Study contacts
- Study coordinator: Vikas Kundra, M.D., Ph.D
- Email: vkundra@som.umaryland.edu
- Phone: 410-328-3477
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.