Contrast-enhanced ultrasound to improve scoring for thyroid cancer diagnosis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This multicenter retrospective study compares two ways of combining gray-scale ultrasound and contrast-enhanced ultrasound (CEUS) — an integrated scoring method and an up-and-down scoring method — for diagnosing thyroid carcinoma. Participants had thyroid nodules with a solid component ≥5 mm and underwent conventional ultrasound, CEUS, and fine-needle aspiration with a final benign or malignant diagnosis. The study follows STARD 2015 reporting standards and excludes cases with indeterminate cytology without final pathology, prior thyroid surgery or ablation, or low-quality images. Diagnostic performance metrics such as sensitivity, specificity, and accuracy will be compared between the two combined scoring approaches.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Participants with thyroid nodules with a solid component ≥5 mm confirmed by conventional ultrasound;
* Participants who underwent conventional ultrasound, contrast-enhanced ultrasound, and fine-needle aspiration biopsy;
* Participants with a final benign or malignant pathological results.

Exclusion Criteria:

* Participants with cytopathology of Bethesda I, III, or IV and without final benign or malignant pathology；
* Participants with a history of thyroid ablation or surgery;
* Participants with low-quality ultrasound images.

Where it's running

• Sun Yat-sen Memorial Hospital, Sun Yat-sen University
  Guangzhou, Guangdong, China Recruiting

Study contacts

• Principal investigator: Jingliang Ruan, Ph.D. — Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
• Study coordinator: Jingliang Ruan, Ph.D.
• Email: ruanjl3@mail.sysu.edu.cn
• Phone: +8613694202230

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.