Condition

Hypoparathyroidism clinical trials and research

• 15Clinical trials
• 5NIH research projects
• 8Countries

Newest Hypoparathyroidism clinical trials

All recruiting trials (15)

• German Hypoparathyroidism Registry

  This registry in Germany collects information from adults with chronic hypoparathyroidism or pseudohypoparathyroidism to better understand how the condition affects people over time and to support future research.

  Recruiting University Hospital Augsburg · Augsburg, Bavaria · NCT07857460

• Encaleret for Chronic Hypoparathyroidism: Testing if it helps symptoms and safety

  This study tests whether taking encaleret pills can help people with chronic hypoparathyroidism, while being safe and tolerable.

  Recruiting at 5 sites Phase 3 Calcilytix Therapeutics, Inc., a BridgeBio company · Reno, Nevada and 4 other locations · NCT07805356

• Palopegteriparatide in adolescents with long-term hypoparathyroidism

  This study tests whether a once-daily palopegteriparatide shot helps adolescents with long‑standing hypoparathyroidism and whether it’s safe for them.

  Recruiting at 3 sites Phase 3 Ascendis Pharma A/S · Bron and 2 other locations · NCT07706764

• Canvuparatide vs placebo in adults with hypoparathyroidism

  This study tests whether weekly canvuparatide can help adults with hypoparathyroidism feel better and keep calcium levels steady compared with a placebo.

  Recruiting at 22 sites Phase 3 MBX Biosciences · Englewood, Colorado and 21 other locations · NCT07699471

• NIRAF-guided identification of parathyroids during thyroidectomy

  A wearable near-infrared autofluorescence device is being tested to help surgeons find and protect the parathyroid glands during thyroid surgery in adults.

  Recruiting Ss. Cyril and Methodius University of Skopje · Skopje · NCT07617584

• Pregnancy registry tracking outcomes after YORVIPATH exposure during pregnancy and breastfeeding

  This registry collects information from pregnant or breastfeeding people with hypoparathyroidism who took YORVIPATH to see if the exposure affects pregnancy, the baby, or infant outcomes through the first year of life.

  Recruiting Ascendis Pharma A/S · Morgantown, West Virginia · NCT07345494

• Palopegteriparatide levels in breast milk of lactating individuals taking YORVIPATH.

  This will see if palopegteriparatide (YORVIPATH) appears in the breast milk of lactating adults with hypoparathyroidism who are breastfeeding.

  Recruiting Ascendis Pharma A/S · Morgantown, West Virginia · NCT07264634

• Validating lab assays, IV catheter techniques, and devices for endocrine, cardiometabolic, and musculoskeletal conditions

  This project will test whether laboratory assays, IV catheter methods, and equipment give consistent, reliable results in adults with or without obesity-related, metabolic, or musculoskeletal conditions.

  Recruiting University of Missouri-Columbia · Columbia, Missouri · NCT07083557

• Higher-dose palopegteriparatide treatment for adults with hypoparathyroidism.

  This 78-week test will see if giving adults with chronic hypoparathyroidism higher doses of palopegteriparatide (above 30 µg/day) is safe and better controls their calcium levels.

  Recruiting at 10 sites Phase 3 Ascendis Pharma A/S · Greeley, Colorado and 9 other locations · NCT07081997

• Investigating EXT608 for adults with hypoparathyroidism

  This study is testing a new treatment called EXT608 to see if it can help adults with hypoparathyroidism feel better compared to a placebo.

  Recruiting Phase 2 Extend Biosciences Inc. · Buenos Aires, Buenos Aires F.D. · NCT06988670

• Parathyroid tissue transplant into the forearm for chronic hypoparathyroidism

  This project will try transplanting donated parathyroid tissue into the forearm of adults with chronic hypoparathyroidism to raise PTH and help normalize their calcium and phosphorus levels.

  Recruiting Phase 1/2 University of California, San Francisco · San Francisco, California · NCT06961071

• Registry for patients with parathyroid disease

  This study is creating a detailed registry for people with parathyroid disorders to collect important health information over 30 years to help with future research.

  Recruiting IRCCS Azienda Ospedaliero-Universitaria di Bologna · Bologna, Bologna · NCT06797934

• Creating a national database for patients with hypoparathyroidism and pseudohypoparathyroidism in Italy

  This study is creating a national database to collect and share information about patients with hypoparathyroidism and pseudohypoparathyroidism in Italy to better understand these rare conditions.

  Recruiting at 4 sites F.I.R.M.O. - Fondazione Italiana Ricerca sulle Malattie dell'Osso - Ente del Terzo Settore · Alessandria and 40 other locations · NCT06645899

• Monitoring the natural history of hypoparathyroidism

  This study is tracking adults with hypoparathyroidism over three years to see how the condition affects their health and to find better ways to manage its complications.

  Recruiting Columbia University · New York, New York · NCT05793853

• Survey on the prevalence and management of hypoparathyroidism in France

  This study is trying to learn more about how common hypoparathyroidism is in France and how people with this condition are being treated.

  Recruiting at 57 sites European Georges Pompidou Hospital · Saint-Denis, La Réunion and 56 other locations · NCT02838927

NIH-funded research (5)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Parathyroid cell transplantation to treat hypoparathyroidism

  A doctor-scientist team at a major university plans a parathyroid cell transplant to help people with chronic hypoparathyroidism reduce dependence on calcium and vitamin D supplements.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11386649

• Long-acting parathyroid hormone treatment for hypoparathyroidism

  A long-lasting parathyroid hormone medicine designed to help people with hypoparathyroidism keep their calcium levels steady and take fewer pills.

  NIH research Extend Biosciences, INC. · Newton, UNITED STATES · NIH-11179115

• Understanding hypoparathyroidism effects on calcium and organ health

  This project follows people with hypoparathyroidism to learn how low parathyroid hormone and calcium levels affect organs and overall health over time.

  NIH research Columbia University Health Sciences · New York, United States · NIH-11145038

• Understanding the effects of hypoparathyroidism on health outcomes.

  This study is looking at hypoparathyroidism, a rare condition that causes low hormone and calcium levels, to better understand how it affects health and leads to problems like kidney issues and heart complications, so we can improve how it's diagnosed and treated for those living with it.

  NIH research Columbia University Health Sciences · New York, United States · NIH-10891413

• A new treatment for low parathyroid hormone levels in patients with hypoparathyroidism

  This study is testing a new way to deliver parathyroid hormone continuously for people with hypoparathyroidism, aiming to help balance calcium and phosphorus levels in the body and make life easier compared to taking multiple daily supplements.

  NIH research Extend Biosciences, INC. · Newton, UNITED STATES · NIH-10822753

Related topics

Quick answers

How many Hypoparathyroidism clinical trials are recruiting right now?

15, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 8 countries. The most sites are in United States (8 trials), Canada (2 trials), Italy (2 trials), France (2 trials), Germany (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 3: 4, Phase 2: 1, Phase 1/2: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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