Ultrasound-guided thermal ablation for certain thyroid nodules
Official title: Ultrasound-guided Thermal Ablation for Bethesda III/IV Thyroid Nodules: A Multicenter Study
Run by Chinese PLA General Hospital · NCT06733753 · Data updated 2026-11-12
This study tests whether a special heat treatment using ultrasound can safely help people with certain thyroid nodules who can't or don't want to have surgery.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 600 (estimated) |
| Sponsor | Chinese PLA General Hospital Academic / other |
| Locations | 2 sites (Beijing, Beijing Municipality and 1 other locations) |
| Status | Recruiting |
| Started | December 9, 2024 |
| Main results expected | December 31, 2028 |
| Study ends | December 31, 2030 |
| Registry record updated | February 14, 2025 |
| Trial ID | NCT06733753 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are patients with Bethesda III or IV thyroid nodules who have refused surgery or are not eligible for surgical intervention.
✕Probably not a fit
Patients with confirmed malignancy or those who do not have suspicious findings on ultrasound will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study evaluates the long-term outcomes of ultrasound-guided thermal ablation specifically for thyroid nodules classified as Bethesda III or IV. It aims to predict clinical outcomes for patients who have confirmed nodules but are either refusing surgery or are ineligible for it. The methodology involves monitoring patients over a follow-up period of at least 12 months to assess the effectiveness and safety of the thermal ablation procedure.
Why it matters
Potential benefit: If successful, this approach could provide a less invasive treatment option for patients with Bethesda III/IV thyroid nodules, potentially avoiding surgery.
How similar studies have gone: While there is ongoing research in thermal ablation for thyroid nodules, this specific approach for Bethesda III/IV nodules is relatively novel and not extensively tested.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. confirmation of Bethesda III or IV on fine- needle aspiration and negative on Braf V600E test 2. no clinical or imaging evidences of extrathyroidal extension, lymph node metastasis and distant metastasis on ultrasound, neck and chest CT 3. refusal or ineligibility for surgery 4. follow-up time ≥12 months Exclusion Criteria: 1. follicular neoplasm or malignancy findings on biopsy 2. no suspicious of malignancy in US 3. patients with contra-lateral vocal cord paralysis 4. follow- up time less than 12 months
Where it's running
-
Chinese PLA General Hospital
Beijing, Beijing Municipality, China Recruiting -
Chinese PLA General Hospital
Beijing, China Not yet recruiting
Study contacts
- Principal investigator: Yukun Luo — Chinese PLA General Hospital
- Study coordinator: Lin Yan
- Email: gemma-y@163.com
- Phone: 13811237313
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.