Condition

Lung Non-Small Cell Carcinoma clinical trials and research

• 29Clinical trials
• 3Countries

Newest Lung Non-Small Cell Carcinoma clinical trials

All recruiting trials (29)

• Atezolizumab after surgery to prevent NSCLC from coming back

  This trial tests whether giving atezolizumab (with or without hyaluronidase) for one year after complete surgery helps prevent NSCLC from returning compared with observation.

  Recruiting at 145 sites Phase 3 National Cancer Institute (NCI) · Anaheim, California and 144 other locations · NCT07388524

• Patient experiences and preferences for IV versus subcutaneous immunotherapy in non-small cell lung cancer

  This survey asks people with non-small cell lung cancer who are receiving immune checkpoint inhibitors whether they prefer IV treatment or subcutaneous injections at the hospital or at home.

  Recruiting at 2 sites University of Southern California · Los Angeles, California and 1 other locations · NCT07339254

• Telisotuzumab vedotin combined with osimertinib for progressive, incurable non-small cell lung cancer

  This trial tests whether adding the antibody-drug telisotuzumab vedotin to ongoing osimertinib can shrink tumors or slow growth in adults with progressive, incurable non-small cell lung cancer who have EGFR mutations.

  Recruiting Phase 2 Jonsson Comprehensive Cancer Center · Los Angeles, California · NCT07323641

• Targeted post-surgery radiation plus standard therapy for NSCLC with remaining nodal cancer

  This phase II trial tests whether adding intensity-modulated post-operative radiation therapy to standard chemotherapy or immunotherapy helps people with non-small cell lung cancer and remaining lymph node cancer after surgery.

  Recruiting at 121 sites Phase 2 Alliance for Clinical Trials in Oncology · Jonesboro, Arkansas and 124 other locations · NCT07293247

• Using blood and tissue biomarkers to guide immunotherapy and later treatment choices in advanced non-small cell lung cancer

  This trial tests whether blood and tumor biomarkers can predict who will respond to first-line PD‑1/PD‑L1 immunotherapy and help pick better second-line treatments for people with stage IIIB–IV non‑small cell lung cancer.

  Recruiting at 13 sites Phase 2 City of Hope Medical Center · Goodyear, Arizona and 12 other locations · NCT07288034

• Psilocybin-assisted therapy for major depression in people with non-small cell lung cancer

  This phase II trial tests whether a single oral dose of psilocybin combined with psychotherapy can reduce moderate-to-severe depression in adults with non-small cell lung cancer.

  Recruiting Phase 2 Ohio State University Comprehensive Cancer Center · Columbus, Ohio · NCT07216404

• How past alcohol or drug use affects detection and treatment of non-small cell lung cancer

  This project will talk with adults who have non-small cell lung cancer and a history of alcohol or drug use to see if those histories help or hinder getting detected and treated.

  Recruiting at 2 sites University of Southern California · Los Angeles, California and 1 other locations · NCT07186699

• Boost immune activity and treatment response with guided interval bike exercise during immunotherapy

  We will test if a home-based, guided interval cycling program can boost immune activity and help people with non-small cell lung cancer tolerate and respond better to immunotherapy.

  Recruiting Fred Hutchinson Cancer Center · Seattle, Washington · NCT06983899

• Using cemiplimab and fianlimab before surgery for non-small cell lung cancer

  This study is testing a combination of two drugs, cemiplimab and fianlimab, before surgery to see if they can help people with stage IB-IIIB non-small cell lung cancer respond better to treatment.

  Recruiting at 2 sites Phase 2 Mayo Clinic · Jacksonville, Florida and 1 other locations · NCT06918132

• Immunotherapy after surgery for early-stage non-small cell lung cancer

  This study is testing if the immunotherapy drug durvalumab can help people with early-stage non-small cell lung cancer stay cancer-free longer after surgery compared to just keeping an eye on them.

  Recruiting at 279 sites Phase 3 National Cancer Institute (NCI) · Jonesboro, Arkansas and 283 other locations · NCT06498635

• Examining the effects of cannabis use in cancer patients undergoing treatment

  This study is trying to see how using cannabis affects newly diagnosed cancer patients who are starting treatment for their illness.

  Recruiting at 491 sites Wake Forest University Health Sciences · Fairbanks, Alaska and 490 other locations · NCT06418204

• Comparing home and clinic administration of nivolumab for cancer treatment

  This study tests whether giving cancer patients their treatment at home instead of in a clinic makes them feel better and prefer their care more.

  Recruiting Phase 2 Mayo Clinic · Jacksonville, Florida · NCT06265285

• Using gilteritinib to treat advanced ALK positive lung cancer

  This study is testing if gilteritinib can safely help people with advanced ALK positive lung cancer who haven't had success with other treatments.

  Recruiting Phase 1 University of Michigan Rogel Cancer Center · Los Angeles, California and 2 other locations · NCT06225427

• Evaluating geriatric assessments for older adults with lung cancer undergoing treatment

  This study tests if using special health assessments for older adults with lung cancer can help them handle treatment better and improve their quality of life.

  Recruiting at 2 sites City of Hope Medical Center · Duarte, California and 2 other locations · NCT06139627

• Improving decision-making for lung cancer treatment

  This study is testing a new communication tool to see if it helps patients with non-small cell lung cancer feel more satisfied and confident in their treatment choices when talking with their doctors.

  Recruiting Mayo Clinic · Rochester, Minnesota · NCT06122064

• Targeted treatment for advanced lung cancer with MET gene amplification

  This study is testing if a new treatment called amivantamab can help people with advanced lung cancer that has extra copies of the MET gene feel better and live longer.

  Recruiting at 250 sites Phase 2 SWOG Cancer Research Network · Jonesboro, Arkansas and 270 other locations · NCT06116682

• Combining advanced radiation therapy with a targeted drug for specific lung cancer patients

  This study is testing whether combining advanced radiation therapy with the drug osimertinib can help people with specific types of lung cancer control their disease better and improve their quality of life.

  Recruiting Phase 2 City of Hope Medical Center · Duarte, California and 1 other locations · NCT06014827

• Using PET scans to guide targeted radiation therapy for certain cancers

  This study is testing if using PET scans to guide targeted radiation therapy can help people with certain cancers, like lung cancer and melanoma, get better results than standard treatment.

  Recruiting at 2 sites Phase 2 City of Hope Medical Center · Duarte, California and 1 other locations · NCT05830058

• AI-guided radiation therapy for lung tumors

  This study is testing if using artificial intelligence to personalize radiation treatment can help people with lung tumors get better results and reduce the chance of their cancer coming back.

  Recruiting Northwestern University · Chicago, Illinois · NCT05802186

• Treatment for lung cancer using targeted chemotherapy delivery

  This study is testing a new way to deliver chemotherapy directly to lung tumors in patients with hard-to-treat lung cancer to see if it helps control tumor growth better than standard treatments.

  Recruiting at 2 sites Phase 2 City of Hope Medical Center · Duarte, California and 1 other locations · NCT05672108

• Surgical order of blood vessel division and circulating tumor DNA after lung cancer surgery

  This compares doing the pulmonary vein first versus the pulmonary artery first during lung cancer surgery to see if it lowers circulating tumor DNA in adults with stage I–III non-small cell lung cancer.

  Recruiting at 4 sites Thomas Jefferson University · Abington, Pennsylvania and 3 other locations · NCT05502523

• Combining adaptive radiation therapy with immunotherapy for advanced lung cancer treatment

  This study is testing a new way of giving radiation therapy along with immunotherapy to see if it helps people with advanced lung cancer feel better and live longer.

  Recruiting Phase 1/2 Vanderbilt-Ingram Cancer Center · Nashville, Tennessee · NCT05501665

• Combining low-dose interleukin-2 and pembrolizumab for advanced lung cancer treatment

  This study is testing a new combination of low-dose interleukin-2 and pembrolizumab to see if it can help people with untreated stage IV non-small cell lung cancer fight their disease better.

  Recruiting Early Phase 1 Emory University · Atlanta, Georgia · NCT05493566

• Improving decision-making for early-stage lung cancer patients

  This study is testing whether giving early-stage lung cancer patients a quality of life fact sheet during their treatment decision-making helps them feel better about their choices compared to usual care.

  Recruiting Roswell Park Cancer Institute · Buffalo, New York · NCT05292521

• A vaccine to treat advanced lung cancer

  This study is testing a new vaccine for advanced lung cancer to see if it can help shrink tumors when combined with a special immune booster.

  Recruiting Phase 2 University of Washington · Omaha, Nebraska and 1 other locations · NCT05242965

• Identifying biomarkers for lung inflammation after cancer treatment

  This study is trying to find early signs of lung inflammation in people with non-small cell lung cancer after they receive chemoradiotherapy and immunotherapy, to help improve their treatment and overall health.

  Recruiting M.D. Anderson Cancer Center · Houston, Texas · NCT04913311

• Combining immunotherapy with chemotherapy for non-small cell lung cancer treatment

  This study is testing if adding an immunotherapy drug to standard chemotherapy can help people with early-stage non-small cell lung cancer live longer and feel better after their surgery.

  Recruiting at 629 sites Phase 3 National Cancer Institute (NCI) · Anchorage, Alaska and 1150 other locations · NCT04267848

• Yoga intervention to improve physical performance and quality of life for cancer patients and their caregivers

  This study tests whether a yoga program can help improve physical performance and quality of life for cancer patients and their caregivers during radiotherapy.

  Recruiting M.D. Anderson Cancer Center · Houston, Texas · NCT03948100

• Exploring gut microbiome and fecal transplant effects on GI issues in cancer patients

  This study is testing how the gut bacteria affect stomach issues in cancer patients receiving certain treatments and whether a stool transplant can help relieve those problems.

  Recruiting Phase 1 M.D. Anderson Cancer Center · Houston, Texas · NCT03819296

Related topics

Quick answers

How many Lung Non-Small Cell Carcinoma clinical trials are recruiting right now?

29, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 3 countries. The most sites are in United States (29 trials), Puerto Rico (1 trial), Guam (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 11, Phase 3: 3, Phase 1: 2, Early Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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