Condition

Stage IIIB Lung Cancer AJCC v8 clinical trials and research

• 14Clinical trials
• 2Countries

Newest Stage IIIB Lung Cancer AJCC v8 clinical trials

All recruiting trials (14)

• Using blood and tissue biomarkers to guide immunotherapy and later treatment choices in advanced non-small cell lung cancer

  This trial tests whether blood and tumor biomarkers can predict who will respond to first-line PD‑1/PD‑L1 immunotherapy and help pick better second-line treatments for people with stage IIIB–IV non‑small cell lung cancer.

  Recruiting at 13 sites Phase 2 City of Hope Medical Center · Goodyear, Arizona and 12 other locations · NCT07288034

• Using cemiplimab and fianlimab before surgery for non-small cell lung cancer

  This study is testing a combination of two drugs, cemiplimab and fianlimab, before surgery to see if they can help people with stage IB-IIIB non-small cell lung cancer respond better to treatment.

  Recruiting at 2 sites Phase 2 Mayo Clinic · Jacksonville, Florida and 1 other locations · NCT06918132

• Immunotherapy after surgery for early-stage non-small cell lung cancer

  This study is testing if the immunotherapy drug durvalumab can help people with early-stage non-small cell lung cancer stay cancer-free longer after surgery compared to just keeping an eye on them.

  Recruiting at 279 sites Phase 3 National Cancer Institute (NCI) · Jonesboro, Arkansas and 283 other locations · NCT06498635

• Combining chemotherapy with immunotherapy for older adults with advanced lung cancer

  This study is testing if adding chemotherapy to immunotherapy can help older adults with advanced lung cancer live longer and feel better compared to just using immunotherapy alone.

  Recruiting at 271 sites Phase 3 National Cancer Institute (NCI) · Fayetteville, Arkansas and 329 other locations · NCT06096844

• Personalized vaccine combined with pembrolizumab for advanced solid tumors

  This study is testing a new personalized cancer vaccine combined with pembrolizumab to see if it helps people with advanced solid tumors fight their cancer better.

  Recruiting Phase 1/2 Mayo Clinic · Jacksonville, Florida · NCT05269381

• Using papaverine with chemoradiation to treat advanced non-small cell lung cancer

  This study is testing the best dose of papaverine combined with chemotherapy and radiation to see if it helps people with advanced non-small cell lung cancer live longer and control their tumors better.

  Recruiting at 2 sites Phase 1 Ohio State University Comprehensive Cancer Center · Duarte, California and 1 other locations · NCT05136846

• Assessing heart health in lung cancer patients receiving personalized chemoradiation

  This study is testing how personalized chemoradiation treatment for lung cancer affects heart health in patients and if adjusting the treatment can help reduce heart disease risk.

  Recruiting M.D. Anderson Cancer Center · Houston, Texas · NCT05010109

• Combining local therapy and durvalumab for advanced lung cancer after initial treatment

  This study is testing whether combining local treatments like surgery or radiation with the immunotherapy durvalumab can help people with advanced lung cancer live longer and feel better after their initial treatment.

  Recruiting Phase 2 M.D. Anderson Cancer Center · Houston, Texas · NCT04892953

• Using canakinumab to prevent lung cancer in high-risk patients

  This study is testing if a medication called canakinumab can help prevent lung cancer in people who have high-risk lung nodules.

  Recruiting Phase 2 M.D. Anderson Cancer Center · Houston, Texas · NCT04789681

• Combining immunotherapy with chemotherapy for non-small cell lung cancer treatment

  This study is testing if adding an immunotherapy drug to standard chemotherapy can help people with early-stage non-small cell lung cancer live longer and feel better after their surgery.

  Recruiting at 629 sites Phase 3 National Cancer Institute (NCI) · Anchorage, Alaska and 1150 other locations · NCT04267848

• Combining osimertinib and bevacizumab for treating advanced EGFR-mutant lung cancer

  This study is testing if adding bevacizumab to osimertinib can help people with advanced EGFR-mutant lung cancer live longer and feel better compared to taking osimertinib alone.

  Recruiting at 328 sites Phase 3 National Cancer Institute (NCI) · Anchorage, Alaska and 603 other locations · NCT04181060

• Respiratory muscle training before lung cancer surgery

  This study is testing if breathing exercises can help lung cancer patients recover better and avoid complications after surgery.

  Recruiting Phase 2 Roswell Park Cancer Institute · Buffalo, New York · NCT04067830

• Yoga intervention to improve physical performance and quality of life for cancer patients and their caregivers

  This study tests whether a yoga program can help improve physical performance and quality of life for cancer patients and their caregivers during radiotherapy.

  Recruiting M.D. Anderson Cancer Center · Houston, Texas · NCT03948100

• Exploring gut microbiome and fecal transplant effects on GI issues in cancer patients

  This study is testing how the gut bacteria affect stomach issues in cancer patients receiving certain treatments and whether a stool transplant can help relieve those problems.

  Recruiting Phase 1 M.D. Anderson Cancer Center · Houston, Texas · NCT03819296

Related topics

Quick answers

How many Stage IIIB Lung Cancer AJCC v8 clinical trials are recruiting right now?

14, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 2 countries. The most sites are in United States (14 trials), Guam (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 5, Phase 3: 4, Phase 1: 2, Phase 1/2: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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