Condition

Metastatic Breast Carcinoma clinical trials and research

• 23Clinical trials
• 1Country

Newest Metastatic Breast Carcinoma clinical trials

All recruiting trials (23)

• Couples Coping Together Against Cancer: A Feasibility and Acceptability Look

  This observational study tests whether a brokered program for patients with cancer and their partners is feasible and acceptable, and whether it may reduce distress over time.

  Recruiting City of Hope Medical Center · Duarte, California · NCT07664579

• Living Well with Advanced Breast Cancer: Understanding Supportive Care Needs

  This project asks adults with advanced (stage IV) breast cancer and their caregivers about what supportive care has helped, what’s been hard, and what help they still need.

  Recruiting Ohio State University Comprehensive Cancer Center · Columbus, Ohio · NCT07227038

• Leuprolide versus goserelin to stop ovarian estrogen production in pre- or peri-menopausal women with breast cancer

  This study tests whether two doses of leuprolide or goserelin better stops the ovaries from making estrogen in pre- or peri-menopausal women with breast cancer.

  Recruiting Phase 2 University of Michigan Rogel Cancer Center · Ann Arbor, Michigan · NCT07158021

• Safety of combining pidnarulex (CX-5461) with trastuzumab deruxtecan for HER2-positive, HER2-low/ultralow breast and other HER2-expressing solid tumors

  This trial tests whether adding pidnarulex to trastuzumab deruxtecan is safe and finds the best dose for adults with HER2-positive, HER2-low/ultralow, or other HER2-expressing advanced or metastatic breast and solid tumors.

  Recruiting at 2 sites Phase 1 National Cancer Institute (NCI) · Boston, Massachusetts and 1 other locations · NCT07137416

• Photon VMAT craniospinal radiation for leptomeningeal disease from breast or non‑small cell lung cancer

  This trial tests whether craniospinal irradiation delivered with photon VMAT can help adults whose breast cancer or non‑small cell lung cancer has spread to the meninges (leptomeningeal disease).

  Recruiting at 2 sites Phase 2 City of Hope Medical Center · Duarte, California and 1 other locations · NCT06910761

• Cemiplimab plus Y-90 radioembolization for breast cancer that has spread to the liver

  This trial tests whether giving the immunotherapy cemiplimab together with Y-90 liver radioembolization can boost immune attack and shrink tumors in people whose breast cancer has spread mainly to the liver.

  Recruiting Phase 2 City of Hope Medical Center · Duarte, California · NCT06860815

• Hippocampal avoidance during craniospinal irradiation for breast and lung cancer with leptomeningeal metastases

  This study is testing a new way of giving radiation therapy to help people with breast or lung cancer that has spread to their brain, aiming to reduce symptoms while protecting their memory.

  Recruiting at 2 sites Phase 2 University of Washington · San Francisco, California and 2 other locations · NCT06518057

• [18F]FTT PET to image PARP expression in metastatic breast cancer

  This test tries to see if an [18F]FTT PET scan can show PARP levels and help detect whether PARP inhibitor treatment (with or without immunotherapy) is working for people with metastatic breast cancer.

  Recruiting Phase 1/2 University of Washington · Seattle, Washington · NCT06502691

• Comparing proton radiation therapy to standard radiation for leptomeningeal metastasis

  This study is testing whether proton radiation therapy is better than standard radiation for people with leptomeningeal metastasis from breast or lung cancer to see if it helps them live longer and stay healthier.

  Recruiting at 58 sites Phase 3 NRG Oncology · Phoenix, Arizona and 57 other locations · NCT06500481

• Measuring a biomarker for breast cancer treatment effectiveness

  This study is testing if measuring a specific biomarker can help doctors understand how well hormone treatments are working for people with advanced breast cancer.

  Recruiting Mayo Clinic · Jacksonville, Florida · NCT06388122

• Using targeted radiation therapy for treating specific metastatic breast cancer cases

  This study is testing if a targeted radiation treatment can help people with certain types of metastatic breast cancer keep taking their regular medication for at least 24 weeks while also checking how it affects their safety and quality of life.

  Recruiting at 2 sites Phase 2 City of Hope Medical Center · Duarte, California and 1 other locations · NCT06260033

• Collecting samples and data from patients with recurrent or metastatic breast cancer

  This study is collecting blood and tissue samples from patients with recurrent or metastatic breast cancer to learn more about the disease and improve treatment options.

  Recruiting Mayo Clinic · Rochester, Minnesota · NCT06217874

• Using electric fields to treat spinal cancer spread in breast cancer patients

  This study tests if wearing a portable device that uses electric fields can help breast cancer patients whose cancer has spread to the spine feel better and slow down tumor growth.

  Recruiting Mayo Clinic · Jacksonville, Florida · NCT05746325

• Adding targeted radiation therapy to drug treatment for breast cancer

  This study is testing whether adding targeted radiation therapy to regular drug treatment can help people with a specific type of breast cancer keep their disease from getting worse or spreading.

  Recruiting at 7 sites Phase 2 Memorial Sloan Kettering Cancer Center · Basking Ridge, New Jersey and 7 other locations · NCT05534438

• Imaging HER2+ Breast Cancer with Brain Metastasis using a New Scan

  This study is testing a new type of scan to see if it can help doctors better understand how well a treatment works for people with HER2+ breast cancer that has spread to the brain.

  Recruiting Phase 4 City of Hope Medical Center · Duarte, California · NCT05376878

• Combining two anti-cancer drugs for patients with advanced tumors

  This study is testing a new combination of two anti-cancer drugs to see if it can help teenagers and adults with advanced tumors feel better and improve their treatment options.

  Recruiting at 7 sites Phase 1 National Cancer Institute (NCI) · Los Angeles, California and 6 other locations · NCT05372640

• Combining Tumor Treating Fields with Cabozantinib or Pembrolizumab and Nab-Paclitaxel for Advanced Solid Tumors

  This study is testing a new treatment that combines tumor treating fields with two different cancer drugs to see if it helps people with advanced solid tumors in the abdomen or chest.

  Recruiting Phase 1 M.D. Anderson Cancer Center · Houston, Texas · NCT05092373

• Lutetium-177 DOTATATE for Stage IV or Recurrent Breast Cancer

  This study tests whether 177Lu-DOTATATE can shrink or slow the growth of breast cancer that has spread or come back in patients whose tumors express SSTR2.

  Recruiting Phase 2 OHSU Knight Cancer Institute · Portland, Oregon · NCT04529044

• Investigating biomarkers and clinical features in metastatic breast cancer patients treated with CDK4/6 inhibitors

  This study is trying to learn more about how metastatic breast cancer patients respond to CDK4/6 inhibitors by looking at their medical records and collecting blood and tissue samples to understand the cancer better.

  Recruiting Roswell Park Cancer Institute · Buffalo, New York · NCT04526587

• Using abemaciclib to treat older patients with hormone receptor positive breast cancer

  This study is testing if the medication abemaciclib can safely help older patients with hormone receptor positive breast cancer feel better and live longer.

  Recruiting at 6 sites Phase 2 City of Hope Medical Center · Duarte, California and 5 other locations · NCT04305834

• Combining Olaparib with Cediranib or AZD6738 for Advanced Breast Cancer with BRCA Mutations

  This study is testing if combining the drugs olaparib with either cediranib or AZD6738 can help women with advanced breast cancer that has BRCA mutations feel better after they’ve already tried other treatments.

  Recruiting Phase 2 M.D. Anderson Cancer Center · Houston, Texas · NCT04090567

• Real-time imaging of tumor blood vessels during surgery

  We will test whether a real-time microscope technique during surgery can show how well blood vessels in adults' solid tumors work and whether that helps predict if systemic cancer medicines can reach the tumor.

  Recruiting Mayo Clinic · Jacksonville, Florida · NCT03823144

• Immunotherapy using tumor-infiltrating lymphocytes for metastatic cancer

  This study is testing a new immunotherapy that uses special white blood cells from patients' tumors to see if it can help people with metastatic cancers get better, especially when combined with another treatment called pembrolizumab.

  Recruiting Phase 2 National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT01174121

Related topics

Quick answers

How many Metastatic Breast Carcinoma clinical trials are recruiting right now?

23, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

All of them have sites in United States. Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 10, Phase 1: 3, Phase 4: 1, Phase 1/2: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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