Assessing heart health in lung cancer patients receiving personalized chemoradiation

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study evaluates cardiovascular injury and cardiac fitness in patients with locally advanced non-small cell lung cancer undergoing personalized chemoradiation. It aims to understand the risk of heart disease associated with treatment and whether this risk can be mitigated by tailoring therapy based on individual patient profiles. Participants will undergo various assessments, including imaging tests and functional walking tests, before, during, and after treatment. The study will follow patients for up to 10 years to monitor long-term cardiac health.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Patient with histologic diagnosis of non-small cell lung cancer, small cell lung cancer, or limited stage - small cell lung cancer (L-SCLC)
2. The recommended treatment is thoracic radiation therapy combined with concurrent systemic therapy (chemotherapy and/or immunotherapy) with or without neoadjuvant and/or adjuvant systemic therapy (chemotherapy, immunotherapy, targeted therapy)
3. \>/= 18 years of age
4. KPS \>/= 70
5. Willing and able to sign informed consents
6. Willing to perform 6minute walking test
7. Willing to preform required cardiac biomarker test for primary end point assessment.

Exclusion criteria:

1. Unable or unwilling to give written informed consent
2. Previous history of RT to the thorax overlapping with the current treatment field.
3. Pregnant or breast-feeding
4. Renal failure necessitating dialysis
5. Unwilling to perform protocol tests
6. Contraindication for any protocol tests

Where it's running

• M D Anderson Cancer Center
  Houston, Texas, United States Recruiting

Study contacts

• Principal investigator: Zhongxing Liao, MD — M.D. Anderson Cancer Center
• Study coordinator: Zhongxing Liao, MD
• Email: zliao@mdanderson.org
• Phone: 832-829-5312

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.