Condition

Stage II Lung Cancer AJCC v8 clinical trials and research

• 14Clinical trials
• 2Countries

Newest Stage II Lung Cancer AJCC v8 clinical trials

All recruiting trials (14)

• Hot-spot SBRT vs standard SBRT for early-stage NSCLC

  This trial tests whether adding intentional high-dose hot spots to SBRT improves tumor control in people with early-stage non-small cell lung cancer.

  Recruiting Phase 2 Roswell Park Cancer Institute · Buffalo, New York · NCT07718672

• Using cemiplimab and fianlimab before surgery for non-small cell lung cancer

  This study is testing a combination of two drugs, cemiplimab and fianlimab, before surgery to see if they can help people with stage IB-IIIB non-small cell lung cancer respond better to treatment.

  Recruiting at 2 sites Phase 2 Mayo Clinic · Jacksonville, Florida and 1 other locations · NCT06918132

• Better Breathing for Early-Stage Lung Cancer Survivors (New York)

  This program tests whether a 12-week home-based breathing exercise routine helps people who had stage I–III lung cancer breathe better, feel less tired, and stay more active.

  Recruiting Roswell Park Cancer Institute · Buffalo, New York · NCT06869447

• Immunotherapy after surgery for early-stage non-small cell lung cancer

  This study is testing if the immunotherapy drug durvalumab can help people with early-stage non-small cell lung cancer stay cancer-free longer after surgery compared to just keeping an eye on them.

  Recruiting at 279 sites Phase 3 National Cancer Institute (NCI) · Jonesboro, Arkansas and 283 other locations · NCT06498635

• Improving decision-making for lung cancer treatment

  This study is testing a new communication tool to see if it helps patients with non-small cell lung cancer feel more satisfied and confident in their treatment choices when talking with their doctors.

  Recruiting Mayo Clinic · Rochester, Minnesota · NCT06122064

• AI-guided radiation therapy for lung tumors

  This study is testing if using artificial intelligence to personalize radiation treatment can help people with lung tumors get better results and reduce the chance of their cancer coming back.

  Recruiting Northwestern University · Chicago, Illinois · NCT05802186

• Surgical order of blood vessel division and circulating tumor DNA after lung cancer surgery

  This compares doing the pulmonary vein first versus the pulmonary artery first during lung cancer surgery to see if it lowers circulating tumor DNA in adults with stage I–III non-small cell lung cancer.

  Recruiting at 4 sites Thomas Jefferson University · Abington, Pennsylvania and 3 other locations · NCT05502523

• Improving decision-making for early-stage lung cancer patients

  This study is testing whether giving early-stage lung cancer patients a quality of life fact sheet during their treatment decision-making helps them feel better about their choices compared to usual care.

  Recruiting Roswell Park Cancer Institute · Buffalo, New York · NCT05292521

• Using papaverine with chemoradiation to treat advanced non-small cell lung cancer

  This study is testing the best dose of papaverine combined with chemotherapy and radiation to see if it helps people with advanced non-small cell lung cancer live longer and control their tumors better.

  Recruiting at 2 sites Phase 1 Ohio State University Comprehensive Cancer Center · Duarte, California and 1 other locations · NCT05136846

• Using canakinumab to prevent lung cancer in high-risk patients

  This study is testing if a medication called canakinumab can help prevent lung cancer in people who have high-risk lung nodules.

  Recruiting Phase 2 M.D. Anderson Cancer Center · Houston, Texas · NCT04789681

• Combining immunotherapy with chemotherapy for non-small cell lung cancer treatment

  This study is testing if adding an immunotherapy drug to standard chemotherapy can help people with early-stage non-small cell lung cancer live longer and feel better after their surgery.

  Recruiting at 629 sites Phase 3 National Cancer Institute (NCI) · Anchorage, Alaska and 1150 other locations · NCT04267848

• Respiratory muscle training before lung cancer surgery

  This study is testing if breathing exercises can help lung cancer patients recover better and avoid complications after surgery.

  Recruiting Phase 2 Roswell Park Cancer Institute · Buffalo, New York · NCT04067830

• Yoga intervention to improve physical performance and quality of life for cancer patients and their caregivers

  This study tests whether a yoga program can help improve physical performance and quality of life for cancer patients and their caregivers during radiotherapy.

  Recruiting M.D. Anderson Cancer Center · Houston, Texas · NCT03948100

• Exploring gut microbiome and fecal transplant effects on GI issues in cancer patients

  This study is testing how the gut bacteria affect stomach issues in cancer patients receiving certain treatments and whether a stool transplant can help relieve those problems.

  Recruiting Phase 1 M.D. Anderson Cancer Center · Houston, Texas · NCT03819296

Related topics

Quick answers

How many Stage II Lung Cancer AJCC v8 clinical trials are recruiting right now?

14, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 2 countries. The most sites are in United States (14 trials), Guam (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 4, Phase 3: 2, Phase 1: 2. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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