Condition

Locally Advanced Lung Non-Small Cell Carcinoma clinical trials and research

• 6Clinical trials
• 3Countries

Newest Locally Advanced Lung Non-Small Cell Carcinoma clinical trials

All recruiting trials (6)

• Combining sotorasib and trastuzumab deruxtecan for advanced KRAS G12C non-small cell lung cancer

  This trial tests whether giving sotorasib with trastuzumab deruxtecan is safe and can shrink tumors or slow progression in people with locally advanced or metastatic non-small cell lung cancer that has a KRAS G12C mutation and progressed after prior targeted therapy, immunotherapy, and chemotherapy.

  Recruiting at 9 sites Phase 1/2 National Cancer Institute (NCI) · Sacramento, California and 8 other locations · NCT07012031

• Investigating heart damage from thoracic radiotherapy in lung cancer patients

  This study is testing how radiation treatment for lung cancer affects heart health in patients to help make treatments safer and more effective.

  Recruiting Fondazione IRCCS Istituto Nazionale dei Tumori, Milano · Milan · NCT06361784

• Adding high dose targeted radiation to usual treatment for advanced lung cancer

  This study is testing if adding a high dose of targeted radiation to the usual chemotherapy and immunotherapy can help people with advanced lung cancer live longer and feel better.

  Recruiting at 446 sites Phase 3 NRG Oncology · Birmingham, Alabama and 476 other locations · NCT05624996

• Personalized vaccine combined with pembrolizumab for advanced solid tumors

  This study is testing a new personalized cancer vaccine combined with pembrolizumab to see if it helps people with advanced solid tumors fight their cancer better.

  Recruiting Phase 1/2 Mayo Clinic · Jacksonville, Florida · NCT05269381

• Using papaverine with chemoradiation to treat advanced non-small cell lung cancer

  This study is testing the best dose of papaverine combined with chemotherapy and radiation to see if it helps people with advanced non-small cell lung cancer live longer and control their tumors better.

  Recruiting at 2 sites Phase 1 Ohio State University Comprehensive Cancer Center · Duarte, California and 1 other locations · NCT05136846

• Assessing heart health in lung cancer patients receiving personalized chemoradiation

  This study is testing how personalized chemoradiation treatment for lung cancer affects heart health in patients and if adjusting the treatment can help reduce heart disease risk.

  Recruiting M.D. Anderson Cancer Center · Houston, Texas · NCT05010109

Related topics

Quick answers

How many Locally Advanced Lung Non-Small Cell Carcinoma clinical trials are recruiting right now?

6, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 3 countries. The most sites are in United States (5 trials), Canada (1 trial), Italy (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 1/2: 2, Phase 3: 1, Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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