Condition

Hematologic Diseases clinical trials and research

• 16Clinical trials
• 6NIH research projects
• 1New in 30 days
• 11Countries

Newest Hematologic Diseases clinical trials

All recruiting trials (16)

• Romiplostim to help platelets grow after donor stem cell transplant

  This phase II trial tests whether weekly romiplostim helps patients over 18 who receive a haploidentical or fully matched unrelated donor stem cell transplant to engraft platelets faster than best supportive care.

  Recruiting Phase 2 Chinese PLA General Hospital · Beijing, Beijing Municipality · NCT07919977

• IL-5 CAR-T therapy for refractory or relapsed eosinophilic leukemia

  We will test whether IL-5 CAR-T cells can help adults with CD125-positive refractory or relapsed eosinophilic leukemia.

  Recruiting Phase 1 Zhejiang University · Hangzhou, Zhejiang · NCT07257640

• Exploring immune defects in young patients with blood disorders

  This study is trying to find out how immune system problems affect young people under 25 with blood disorders like autoimmune issues and bone marrow failure.

  Recruiting at 7 sites Meyer Children's Hospital IRCCS · Montreal, Canada and 6 other locations · NCT06857604

• HLA mismatched stem cell transplantation for hematologic diseases

  This study is testing if using stem cells from donors who aren't a perfect match can help people with blood cancers get the treatment they need when they can't find a suitable donor.

  Recruiting Phase 1 Zhejiang University · Hangzhou, China · NCT06809699

• Go Wish Game to support advance care planning for adults with cancer or blood cancers

  This project tries the Go Wish Game to help adults with refractory leukemia, lymphoma, multiple myeloma, or advanced solid tumors and their caregivers have end-of-life conversations and complete advance care planning.

  Recruiting Azienda USL Reggio Emilia - IRCCS · Reggio Emilia · NCT06795815

• Home blood transfusions for people with advanced blood cancers in hospice

  The study will test whether offering home blood transfusions to adults with advanced or relapsed blood cancers who are eligible for hospice helps improve quality of life, mood, and end-of-life care.

  Recruiting at 2 sites Dana-Farber Cancer Institute · Boston, Massachusetts and 1 other locations · NCT06487247

• Assessing the effectiveness of teclistamab for multiple myeloma

  This study is testing if teclistamab can help people with relapsed or hard-to-treat multiple myeloma who have already tried at least three other treatments.

  Recruiting at 16 sites Universitaire Ziekenhuizen KU Leuven · Bonheiden, Antwerpen and 16 other locations · NCT06477783

• Centralizing biological samples for patients with blood cancers

  This study is trying to collect and analyze blood samples from young patients with blood cancers to help improve treatments and research for these conditions.

  Recruiting at 3 sites Meyer Children's Hospital IRCCS · Florence and 2 other locations · NCT06304194

• Evaluating a new CAR-T cell therapy for relapsed/refractory multiple myeloma

  This study is testing a new CAR-T cell therapy called OriCAR-017 to see if it can help people with relapsed or refractory multiple myeloma feel better and improve their treatment outcomes.

  Recruiting Phase 1 OriCell Therapeutics Co., Ltd. · Atlanta, Georgia · NCT06271252

• Using leftover patient samples for clinical research on blood diseases

  This study is trying to use leftover blood and tissue samples from patients to help learn more about blood diseases.

  Recruiting Invivoscribe, Inc. · San Diego, California · NCT06222164

• CD7 CAR-T therapy followed by allogeneic stem cell transplant for relapsed/refractory CD7-positive blood cancers

  This will test whether CD7-directed CAR-T cells given before an allogeneic stem cell transplant are safe for adults with relapsed or refractory CD7-positive acute leukemias.

  Recruiting Phase 1/2 Zhejiang University · Hangzhou, Zhejiang · NCT05827835

• Evaluating a single dose of CTX001 for treating transfusion-dependent beta-thalassemia and severe sickle cell disease

  This study is testing a single dose of a new treatment called CTX001 to see if it can help people with transfusion-dependent beta-thalassemia or severe sickle cell disease feel better.

  Recruiting at 6 sites Phase 3 Vertex Pharmaceuticals Incorporated · New York, New York and 5 other locations · NCT05477563

• Transplanting frozen testicular tissue to restore fertility in men

  This study is testing if transplanting frozen testicular tissue can help men who had cancer as boys regain their ability to father children later in life.

  Recruiting Universitair Ziekenhuis Brussel · Brussels · NCT05414045

• Genomic analysis for patients with inherited bone marrow failure

  This study is testing if advanced genetic testing can help identify the causes of inherited bone marrow failure in patients, so they can get better treatment and support.

  Recruiting Peter MacCallum Cancer Centre, Australia · Melbourne, Victoria · NCT05196789

• Stem cell transplant with T-allo10 cell therapy for hematologic diseases

  This study is testing a new cell therapy called T-allo10 to see if it can help children and young adults with serious blood cancers after a stem cell transplant while reducing the risk of complications.

  Recruiting Phase 1 Stanford University · Palo Alto, California · NCT04640987

• Stem cell transplant using modified donor cells for children and young adults

  This study is testing a new way to use modified stem cells from partially matched donors to see if it can make transplants safer and more effective for children and young adults with blood diseases.

  Recruiting Stanford University · Palo Alto, California · NCT04249830

NIH-funded research (6)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• First-in-class complement inhibitor for blood diseases that damage red blood cells

  A new, targeted therapy being developed to help people with blood diseases like PNH and AIHA by blocking the immune system’s complement attack on red blood cells.

  NIH research Cleveland Clinic Lerner Com-Cwru · Cleveland, United States · NIH-11536949

• Mentored research training and professional development for kidney, urologic, and hematologic diseases

  A program to help trainees in Philadelphia-area kidney, urologic, and blood disease research build skills, get mentoring, and prepare for future scientific careers.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11355595

• A new targeted drug to block harmful complement activity in blood disorders

  A novel nanobody drug designed to block the complement system to help people with PNH or autoimmune hemolytic anemia.

  NIH research Cleveland Clinic Lerner Com-Cwru · Cleveland, United States · NIH-11184452

• Training program for researchers in kidney, urologic, and blood diseases

  This program is designed to help people training in kidney, urologic, and blood diseases become better researchers by offering mentorship, resources, and support to boost their skills and career opportunities.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11168979

• Creating a new treatment to block harmful immune responses in blood diseases

  This study is working on a new treatment to help people with blood disorders like PNH and AIHA by creating special therapies that can stop the body from destroying red blood cells too quickly, aiming to offer better options than what’s currently available.

  NIH research Cleveland Clinic Lerner Com-Cwru · Cleveland, United States · NIH-10990215

• Gene editing in bone marrow to treat blood disorders

  This study is exploring a new way to use gene editing to treat blood disorders like sickle cell disease and β-thalassemia by making changes directly in the bone marrow, which could be safer and cheaper than current methods.

  NIH research University of Kentucky · Lexington, United States · NIH-10756130

Related topics

Quick answers

How many Hematologic Diseases clinical trials are recruiting right now?

16, as of November 12, 2026. 1 of them was first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 11 countries. The most sites are in United States (6 trials), China (4 trials), Italy (4 trials), Belgium (2 trials), Australia (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 1: 4, Phase 1/2: 1, Phase 3: 1, Phase 2: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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