Hydroxyurea for children with sickle cell anemia in Africa
Realizing Effectiveness Across Continents with Hydroxyurea(REACH): A Phase I/II Pilot Study of Hyroxyurea for Children with Sickle Cell Anemia
This project gives hydroxyurea to young children with sickle cell anemia in sub-Saharan Africa to help reduce pain crises, hospital visits, and early death while monitoring safety.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cincinnati Childrens Hosp Med Ctr NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project ID | NIH-11167449 on NIH RePORTER |
What this research studies
If your child joins, they will be tested to confirm sickle cell anemia and started on hydroxyurea at a clinic in one of the participating African countries. Doctors will gradually raise the dose to each child's highest safe level while doing regular blood tests and health checks. The research teams will record illnesses, pain crises, hospital stays, growth, and any side effects over time. The work is focused on making sure hydroxyurea can be used safely and effectively for children living in Angola, the Democratic Republic of Congo, Kenya, and Uganda.
Who could benefit from this research
Good fit: Young children (newborns through about 11 years) with confirmed sickle cell anemia who can attend regular visits at participating clinics in the listed African countries.
Not a fit: Children without sickle cell anemia, those older than the study age range, or those with medical conditions that make hydroxyurea unsafe are unlikely to benefit from this project.
Why it matters
Potential benefit: If successful, this could lower painful crises, infections, hospital stays, and early deaths for children with sickle cell anemia in sub-Saharan Africa.
How similar studies have performed: Hydroxyurea has been shown to reduce complications of sickle cell anemia in many studies in high-income countries, and REACH provides important evidence about safe dosing and benefits for children in Africa.
Where this research is happening
Cincinnati, United States
- Cincinnati Childrens Hosp Med Ctr — Cincinnati, United States (Active)
Researchers
- Principal investigator: Ware, Russell E — Cincinnati Childrens Hosp Med Ctr
- Study coordinator: Ware, Russell E
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.