Understanding brain function and injury in children with sickle cell anemia
The Impact of Cerebral Metabolic Stress on the Development of the Structural and Functional Connectome in Pediatric Sickle Cell Anemia
This study is looking at how stress on the body affects brain growth and thinking skills in kids with sickle cell anemia, even if they haven't had a stroke, to find ways to help them avoid long-term learning challenges.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project ID | NIH-11076225 on NIH RePORTER |
What this research studies
This research investigates how metabolic stress affects brain development and function in children with sickle cell anemia. It aims to understand the mechanisms behind cognitive decline in these children, even when they haven't had a stroke. By using advanced MRI techniques, the study will measure brain oxygen metabolism and connectivity to identify potential biomarkers for cognitive dysfunction. The goal is to develop better screening tools and interventions to prevent long-term disabilities in this vulnerable population.
Who could benefit from this research
Good fit: Ideal candidates for this research are children aged 0-11 years diagnosed with sickle cell anemia.
Not a fit: Patients who do not have sickle cell anemia or are older than 11 years may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnostic tools and treatments that enhance cognitive function and quality of life for children with sickle cell anemia.
How similar studies have performed: Other research has shown promising results in understanding brain function and injury in similar populations, indicating that this approach has potential for success.
Where this research is happening
Saint Louis, United States
- Washington University — Saint Louis, United States (Active)
Researchers
- Principal investigator: Fields, Melanie Erin — Washington University
- Study coordinator: Fields, Melanie Erin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.