Investigating ovarian health in women with sickle cell anemia
Official title: OVARIAN RESERVE IN POST-MENARCHAL FEMALES WITH SICKLE CELL ANEMIA
Funded at Johns Hopkins University · NIH-10901879 · Data updated 2026-11-12
This study is looking at how sickle cell anemia and its treatment with hydroxyurea might affect women's ability to have children, helping to provide important information for women with this condition about their reproductive health.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | August 9, 2020 |
| Project end | July 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $198,065 |
| NIH project number | 5K23HL146841-05 |
| Project ID | NIH-10901879 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are women diagnosed with sickle cell anemia, particularly those who have been treated with hydroxyurea.
✕Less likely to help
Patients without a diagnosis of sickle cell anemia or those who have not received treatment with hydroxyurea may not benefit from this research.
What this research studies
This research focuses on understanding how sickle cell anemia (SCA) and its treatment with hydroxyurea may impact ovarian reserve in women. By evaluating the reproductive health of women with SCA, the study aims to identify potential risks associated with fertility and the effects of long-term treatment. The research will involve a detailed assessment of ovarian function and how it relates to the severity of the disease and treatment duration. This information is crucial for guiding reproductive health decisions for women living with SCA.
Why it matters
Potential benefit: If successful, this research could provide critical insights that help improve fertility management and reproductive health care for women with sickle cell anemia.
How similar studies have gone: Previous research has indicated potential fertility risks associated with sickle cell anemia and its treatments, suggesting that this area of investigation is both relevant and necessary.
Where this research is happening
-
Johns Hopkins University
Baltimore, United States Active
Researchers
- Principal investigator: Pecker, Lydia — Johns Hopkins University
- Study coordinator: Pecker, Lydia
Related research
Other NIH-funded projects on the same topics.
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Hydroxyurea to help children with sickle cell anemia in Africa
A pediatric study tests hydroxyurea treatment for young children with sickle cell anemia in several African countries to see if it can reduce illness and improve health.
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Hydroxyurea for Children with Sickle Cell in Africa
A pilot study tests hydroxyurea in young children with sickle cell disease across several African countries to see if it can reduce illness and hospital visits.
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Hydroxyurea for Children with Sickle Cell Disease in Africa
A safe and feasible use of hydroxyurea for young children with sickle cell disease in several African countries to reduce illness and improve daily life.
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Hypoxemia during Sleep in Sickle Cell Disease: How Common is It and How Might Treatments Help
This study looks at how low oxygen during sleep affects adults with sickle cell disease and how they respond to therapy across multiple urban and rural sites.
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Hypoxic red blood cells for sickle cell anemia using the Hemanext ONE system
A new approach using special low-oxygen red blood cells from the Hemanext ONE system is being tested to help adults and children with sickle cell anemia who rely on frequent transfusions.
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Hydroxyurea for Children with Sickle Cell Anemia in Africa
A safety and feasibility pilot study tests giving hydroxyurea to young children with sickle cell anemia in sub-Saharan Africa to reduce illness and death.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.