Condition

Sentinel Lymph Node clinical trials and research

• 24Clinical trials
• 1NIH research projects
• 18Countries

Newest Sentinel Lymph Node clinical trials

All recruiting trials (24)

• Using indocyanine green to find sentinel lymph nodes during mastectomy

  This pilot will test whether injecting indocyanine green and using fluorescence during mastectomy can find sentinel lymph nodes in women with clinically node-negative invasive breast cancer.

  Recruiting at 2 sites St. Antonius Hospital · Zwolle, Overijssel and 1 other locations · NCT07362485

• Fast detection of cancer in sentinel lymph nodes using a new NIR-II fluorescent probe.

  This test applies a new near-infrared (NIR-II) fluorescent probe to freshly removed sentinel lymph nodes to quickly tell adults with breast cancer whether the cancer has spread there.

  Recruiting Yunnan Cancer Hospital · Kunming, Yunnan · NCT07154563

• Using indocyanine green to identify sentinel lymph nodes during breast cancer surgery

  This project tests whether indocyanine green dye and a fluorescence camera can be used instead of the radioactive tracer to find sentinel lymph nodes in adults having breast cancer surgery who are clinically node-negative.

  Recruiting at 7 sites St. Antonius Hospital · Alkmaar and 6 other locations · NCT07146295

• Two-point versus four-point cervical methylene blue injections for sentinel lymph node mapping in stage I endometrial cancer

  This test checks whether using four cervical methylene blue injections instead of the usual two helps surgeons find sentinel lymph nodes in people with newly diagnosed stage I endometrial cancer who are having surgery.

  Recruiting at 2 sites Dokuz Eylul University · Ankara and 1 other locations · NCT07040657

• Using advanced imaging technology for early-stage breast cancer surgery

  This study is testing a new imaging tool during breast cancer surgery to see if it can help doctors find lymph nodes more accurately and improve treatment for patients.

  Recruiting Fudan University · Shanghai, Shanghai Municipality · NCT06911528

• New imaging technology for identifying breast cancer and lymph node status

  This study is testing a new imaging technology to help doctors better identify breast cancer and check lymph nodes during surgery for patients with breast cancer.

  Recruiting Yunnan Cancer Hospital · Kunming, Yunnan · NCT06713161

• Minimally invasive surgery for early-stage colon cancer

  This study is testing a new, less invasive surgery for early-stage colon cancer to see if it can lower the chances of cancer coming back compared to the standard surgery.

  Recruiting Meander Medical Center · Amersfoort · NCT06652672

• Tailoring axillary surgery for breast cancer patients

  This study is testing if some early breast cancer patients can skip certain surgeries to remove lymph nodes, which might help them avoid unnecessary complications and costs.

  Recruiting KK Women's and Children's Hospital · Singapore · NCT06259513

• Using a low dose of Magtrace to locate lymph nodes in breast cancer patients

  This study is testing if a low dose of a new tracer can help find lymph nodes in breast cancer patients as well as the traditional methods do.

  Recruiting Phase 2 Vastra Gotaland Region · Gothenburg · NCT06169072

• Using optical guidance for sentinel node biopsy in vulvar cancer

  This study is testing if using special imaging techniques can help doctors better identify lymph nodes in women with vulvar cancer to improve their treatment options.

  Recruiting Copenhagen University Hospital, Rigshospitalet · Copenhagen · NCT06161428

• Using optical guidance for sentinel node biopsy in vulvar cancer

  This study is testing if using a special dye can help doctors find lymph nodes in women with early-stage vulvar cancer, to see if it makes the procedure easier and more accurate.

  Recruiting Copenhagen University Hospital, Rigshospitalet · Copenhagen · NCT06029504

• Avoiding sentinel lymph node biopsy in early breast cancer patients

  This study is testing whether women with early breast cancer can safely skip a specific lymph node surgery to see if it helps them recover better and have less swelling in their arms.

  Recruiting The First Affiliated Hospital with Nanjing Medical University · Nanjing, Jiangsu · NCT05935150

• Evaluating sentinel lymph node biopsy for early-stage ovarian cancer

  This study is testing if a new type of lymph node surgery can help women with early-stage ovarian cancer get better treatment while reducing the risks of more extensive surgery.

  Recruiting Istanbul University · Istanbul, Turkey · NCT05927818

• Comparing two surgical approaches for early mouth cancers

  This study is testing whether a less invasive surgery for early mouth cancers can provide similar survival rates while being easier on patients and more affordable than the standard approach.

  Recruiting Tata Memorial Hospital · Mumbai, Maharashtra and 2 other locations · NCT05774483

• Target axillary dissection after chemotherapy for locally advanced breast cancer

  This study is testing if a new surgery method for removing lymph nodes after chemotherapy can help people with locally advanced breast cancer have better outcomes.

  Recruiting at 2 sites Hospital Universitari de Bellvitge · L'Hospitalet de Llobregat, Barcelona and 1 other locations · NCT05763641

• Chemoradiation for vulvar cancer patients with large sentinel node metastasis

  This study is testing if combining chemotherapy and radiation can be a safer and more effective treatment for women with early-stage vulvar cancer who have larger cancer spread in their lymph nodes, instead of having surgery.

  Recruiting at 27 sites Phase 2 University Medical Center Groningen · Orange, California and 26 other locations · NCT05076942

• Comparing axillary radiotherapy and lymphadenectomy in breast cancer patients after neoadjuvant therapy

  This study is testing whether using axillary radiotherapy instead of surgery can help breast cancer patients who have had neoadjuvant treatment avoid lymphedema.

  Recruiting at 57 sites Hospital Universitari de Bellvitge · Sydney, New South Wales and 60 other locations · NCT04889924

• Using nanoparticles for delayed lymph node biopsy in breast cancer patients

  This study is testing if using special nanoparticles can help breast cancer patients avoid unnecessary surgery by identifying important lymph nodes only when needed.

  Recruiting at 9 sites Phase 3 Uppsala University · Houston, Texas and 8 other locations · NCT04722692

• Targeted Axillary Dissection for Early-stage Breast Cancer

  This study tests a new surgery method for early-stage breast cancer to see if using a special seed to find and remove positive lymph nodes works better than traditional methods.

  Recruiting at 3 sites Jewish General Hospital · Montreal, Quebec and 2 other locations · NCT04671511

• Improving treatment for inflammatory breast cancer

  This study is testing if using a special dye and a radioactive substance can help doctors find important lymph nodes during surgery for people with inflammatory breast cancer.

  Recruiting Dana-Farber Cancer Institute · Boston, Massachusetts · NCT04636710

• Examining the impact of small-volume lymph node disease in endometrial and cervical cancer

  This study is trying to see how small amounts of cancer in lymph nodes affect treatment choices and outcomes for people with early-stage endometrial and cervical cancer.

  Recruiting Fondazione IRCCS Istituto Nazionale dei Tumori, Milano · Milan · NCT04403867

• Evaluating axillary treatment options for breast cancer patients after chemotherapy

  This study is testing if early stage breast cancer patients can skip extra treatments for their underarm area after chemotherapy if their lymph nodes show no signs of cancer.

  Recruiting at 95 sites University Hospitals of Derby and Burton NHS Foundation Trust · Dublin and 97 other locations · NCT04109079

• Evaluating Sentinel Node Biopsy for Endometrial Cancer Treatment

  This study is testing if a new approach called sentinel node biopsy can help women with early-stage endometrial cancer recover better and have fewer complications compared to the traditional surgery method.

  Recruiting at 21 sites Phase 3 Queensland Centre for Gynaecological Cancer · Houston, Texas and 22 other locations · NCT04073706

• Near‑infrared guided removal of lung nodules and sentinel lymph nodes

  This will test whether injecting a tiny amount of near‑infrared dye near a lung nodule helps surgeons find and remove the nodule and the first draining (sentinel) lymph node in adults having lung surgery.

  Recruiting Phase 1/2 Massachusetts General Hospital · Boston, Massachusetts · NCT03097575

NIH-funded research (1)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Examining lymph node biopsy techniques after chemotherapy in advanced breast cancer patients

  This study is looking at whether a less invasive procedure called sentinel lymph node biopsy can help women with locally advanced breast cancer who have received chemotherapy, making it easier to check for cancer spread in the armpit without needing more complicated surgeries.

  NIH research Sloan-Kettering Inst Can Research · New York, United States · NIH-10656553

Related topics

Quick answers

How many Sentinel Lymph Node clinical trials are recruiting right now?

24, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 18 countries. The most sites are in United States (5 trials), Netherlands (4 trials), China (4 trials), Singapore (2 trials), Spain (2 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 3: 2, Phase 2: 2, Phase 1/2: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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