Using a low dose of Magtrace to locate lymph nodes in breast cancer patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to evaluate the effectiveness of superparamagnetic iron oxide nanoparticles (SPIO) as a tracer in an ultra-low dose for sentinel lymph node (SLN) detection in breast cancer patients. Participants will undergo SLN biopsy using both the SPIO method and the traditional dual technique involving Technetium99m and possibly blue dye. The study will compare the detection rates of SLNs between these two methods and assess any MRI breast artefacts and skin staining over time. This prospective cohort study will provide insights into the non-inferiority of the new technique compared to the standard approach.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Planned for sentinel lymph node biopsy at (or after) breast surgery
* Signed and dated written informed consent before the start of specific protocol procedures

Exclusion Criteria:

* Pregnant or breast-feeding
* Iron overload disease
* Known hypersensitivity to iron, dextran compounds or blue dye.
* Inability to understand given information and give informed consent or undergo study procedures

Where it's running

• Sahlgrenska Iniversity Hospital
  Gothenburg, Sweden Recruiting

Study contacts

• Principal investigator: Fredrik Wärnberg — Sahlgrenska University Hospital
• Study coordinator: Fredrik Wärnberg
• Email: fredrik.warnberg@vgregion.se
• Phone: +4631823931

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Using indocyanine green to find sentinel lymph nodes during mastectomy

  This pilot will test whether injecting indocyanine green and using fluorescence during mastectomy can find sentinel lymph nodes in women with clinically node-negative invasive breast cancer.

  Recruiting at 2 sites St. Antonius Hospital · Zwolle, Overijssel and 1 other locations · NCT07362485

• Using indocyanine green to identify sentinel lymph nodes during breast cancer surgery

  This project tests whether indocyanine green dye and a fluorescence camera can be used instead of the radioactive tracer to find sentinel lymph nodes in adults having breast cancer surgery who are clinically node-negative.

  Recruiting at 7 sites St. Antonius Hospital · Alkmaar and 6 other locations · NCT07146295

• Using advanced imaging technology for early-stage breast cancer surgery

  This study is testing a new imaging tool during breast cancer surgery to see if it can help doctors find lymph nodes more accurately and improve treatment for patients.

  Recruiting Fudan University · Shanghai, Shanghai Municipality · NCT06911528

• New imaging technology for identifying breast cancer and lymph node status

  This study is testing a new imaging technology to help doctors better identify breast cancer and check lymph nodes during surgery for patients with breast cancer.

  Recruiting Yunnan Cancer Hospital · Kunming, Yunnan · NCT06713161

• Tailoring axillary surgery for breast cancer patients

  This study is testing if some early breast cancer patients can skip certain surgeries to remove lymph nodes, which might help them avoid unnecessary complications and costs.

  Recruiting KK Women's and Children's Hospital · Singapore · NCT06259513

• Avoiding sentinel lymph node biopsy in early breast cancer patients

  This study is testing whether women with early breast cancer can safely skip a specific lymph node surgery to see if it helps them recover better and have less swelling in their arms.

  Recruiting The First Affiliated Hospital with Nanjing Medical University · Nanjing, Jiangsu · NCT05935150

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.