Fast detection of cancer in sentinel lymph nodes using a new NIR-II fluorescent probe.

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational protocol uses an ex vivo approach in which freshly excised sentinel lymph nodes are incubated briefly in graded concentrations of a pan-cytokeratin-targeting NIR-II probe and then imaged with a dedicated NIR-II system. Imaging data are processed with quantitative algorithms to generate fluorescence-based predictions of metastatic involvement. Multiple incubation times and probe concentrations are explored to optimize signal and speed. Final diagnoses are confirmed by standard histopathology to compare accuracy and concordance with the fluorescence readout.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adult patients between 18-75 years of age
* Patients presenting with a breast nodule or mass presumed to be resectable on pre-operative assessment
* Breast cancer patients who are scheduled to undergo sentinel lymph node biopsy or axillary lymph node dissection;
* Good operative candidate
* Subject capable of giving informed consent and participating in the process of consent

Exclusion Criteria:

* Patients unable to participate in the consent process
* Patients had contraindications to surgery, such as serious cardiopulmonary disease, coagulation dysfunction, etc

Where it's running

• Yunnan Cancer Hospital, Kunming, Yunnan 650118
  Kunming, Yunnan, China Recruiting

Study contacts

• Study coordinator: Junhong Chen, Postgraduate
• Email: 1145644908@qq.com
• Phone: 86+17782287838

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.