Condition

Metastasis clinical trials and research

• 28Clinical trials
• 489NIH research projects
• 22Countries

Newest Metastasis clinical trials

All recruiting trials (28)

• Luvometinib plus Anlotinib in KRAS-mutated NSCLC

  This study tests whether the combination of luvometinib and anlotinib helps people with KRAS-mutated metastatic non-small cell lung cancer who have tried prior treatments.

  Recruiting Phase 2 Shanghai Fosun Pharmaceutical Industrial Development Co. Ltd. · Shanghai, Shanghai Municipality · NCT07562581

• Gefitinib, trametinib, disulfiram, and sunitinib added to standard chemotherapy for metastatic osteosarcoma

  This study tests whether adding gefitinib, trametinib, disulfiram, and sunitinib to standard chemotherapy helps people with newly diagnosed metastatic osteosarcoma.

  Recruiting at 7 sites Phase 2 Memorial Sloan Kettering Cancer Center · Basking Ridge, New Jersey and 6 other locations · NCT07477457

• Outcomes for Oligometastatic and Oligorecurrent Cervical Cancer

  This registry will see if adding local treatments such as radiation or surgery to standard systemic therapy helps people with oligo‑metastatic or oligo‑recurrent cervical cancer live longer or avoid progression.

  Recruiting Tata Memorial Hospital · Mumbai, Maharashtra · NCT07400809

• Fast detection of cancer in sentinel lymph nodes using a new NIR-II fluorescent probe.

  This test applies a new near-infrared (NIR-II) fluorescent probe to freshly removed sentinel lymph nodes to quickly tell adults with breast cancer whether the cancer has spread there.

  Recruiting Yunnan Cancer Hospital · Kunming, Yunnan · NCT07154563

• Two-point versus four-point cervical methylene blue injections for sentinel lymph node mapping in stage I endometrial cancer

  This test checks whether using four cervical methylene blue injections instead of the usual two helps surgeons find sentinel lymph nodes in people with newly diagnosed stage I endometrial cancer who are having surgery.

  Recruiting at 2 sites Dokuz Eylul University · Ankara and 1 other locations · NCT07040657

• Real-world look at SKB264 in HER2-negative breast cancer that has come back or spread

  This real-world study tests sacituzumab tirumotecan (SKB264) alone or with others in adults with recurrent or metastatic HER2-negative breast cancer.

  Recruiting at 12 sites Cancer Institute and Hospital, Chinese Academy of Medical Sciences · Hefei, Anhui and 18 other locations · NCT06993506

• Using blood markers to improve treatment for metastatic pancreatic cancer

  This study is testing if analyzing certain blood markers can help doctors better tailor treatments for patients with advanced pancreatic cancer starting a specific chemotherapy regimen.

  Recruiting Beneficência Portuguesa de São Paulo · São Paulo, São Paulo · NCT06945978

• Ifinatamab deruxtecan alone or with other drugs for metastatic castration‑resistant prostate cancer

  This trial tests whether ifinatamab deruxtecan, given alone or with other cancer drugs, helps men with metastatic castration‑resistant prostate cancer by lowering PSA and controlling disease.

  Recruiting at 80 sites Phase 1/2 Merck Sharp & Dohme LLC · Los Angeles, California and 81 other locations · NCT06863272

• Removal of the primary small-intestine neuroendocrine tumor versus systemic therapy alone

  This project tries to see if removing the main small-intestine neuroendocrine tumor helps people with incurable metastatic disease live longer or avoid future problems, compared with treating them with systemic therapy alone.

  Recruiting Insel Gruppe AG, University Hospital Bern · Bern · NCT06787014

• Personalized PULSAR MRI-guided radiation for central lung tumors

  This will test whether personalized, MRI-guided PULSAR radiation given as five widely spaced high-precision doses can safely treat small central primary or metastatic lung tumors.

  Recruiting Early Phase 1 University of Texas Southwestern Medical Center · Dallas, Texas · NCT06712745

• Evaluating radiation dose effects in prostate cancer treatment with 177Lu-PSMA-617

  This study is testing how much radiation is given to tumors and nearby organs in patients with advanced prostate cancer who are being treated with a specific drug called 177Lu-PSMA-617.

  Recruiting Institut Bergonié · Bordeaux · NCT06700057

• Evaluating PSMA PET/CT Imaging for Prostate Cancer Patients

  This study is testing a special type of imaging called PSMA PET/CT to see if it can help find cancer in adults who have or might have prostate cancer.

  Recruiting at 3 sites Tianjin Medical University · Hefei, Anhui and 2 other locations · NCT06690970

• Evaluating PET/CT for SSTR-related diseases

  This study is testing a new type of PET/CT scan to see if it can help find cancer spots in adults who have tumors related to SSTR diseases.

  Recruiting at 3 sites Tianjin Medical University · Hefei, Anhui and 2 other locations · NCT06690957

• Imaging CXCR4-related diseases using PET/CT

  This study is testing a new type of imaging to see if it can better identify and track diseases related to CXCR4 in patients.

  Recruiting at 3 sites Tianjin Medical University · Hefei, Anhui and 2 other locations · NCT06690736

• Evaluating FAPI PET/CT for Diagnosing FAP-Related Diseases

  This study is testing if a special type of scan can help find cancer in adults who have or might have tumors related to FAP.

  Recruiting at 3 sites Tianjin Medical University · Hefei, Anhui and 2 other locations · NCT06688071

• Treatment for breast cancer that has spread to the liver using a new ablation technique

  This study is testing a new treatment method for breast cancer that has spread to the liver to see if it works better than the standard approach.

  Recruiting Ruijin Hospital · Shanghai · NCT06567353

• Oral Alintegimod with Ipilimumab followed by Nivolumab for advanced cancer

  This study is testing if a new oral medication called Alintegimod, combined with two other cancer treatments, can help people with advanced solid tumors feel better and live longer.

  Recruiting at 4 sites Phase 1/2 7 Hills Pharma, LLC · Aurora, Colorado and 4 other locations · NCT06362369

• Predicting tumor spread using a radiomics model

  This study is testing a new way to predict where advanced cancer might spread in patients who haven't shown signs of metastasis yet, to help with earlier diagnosis and treatment.

  Recruiting at 2 sites Fudan University · Shanghai, Shanghai Municipality and 1 other locations · NCT06202404

• Radiation treatment for high-risk spine cancer patients

  This study is testing a new type of radiation treatment for patients with cancer that has spread to the spine to see if it can help manage their condition without needing major surgery.

  Recruiting Phase 2 Stony Brook University · Stony Brook, New York · NCT06165419

• Palliative care led by clinical nurse specialists for patients with advanced cancer

  This study is testing if having a specialized nurse-led team for palliative care can help adults with advanced cancer feel better and live longer compared to regular care.

  Recruiting Good Samaritan Hospital Medical Center, New York · West Islip, New York · NCT05947695

• Evaluating the effects of radiotherapy on patients with oligometastatic cancer

  This study is testing how well Stereotactic Ablative Radiotherapy (SABR) works for people with oligometastatic cancer to see if it can help them live longer and feel better.

  Recruiting Institut Investigacio Sanitaria Pere Virgili · Albacete, Albacete and 20 other locations · NCT05933876

• Combining ONC201 and Atezolizumab for treating obesity-related endometrial cancer

  This study is testing a new treatment for advanced or recurrent endometrial cancer in obese women by combining two drugs, ONC201 and atezolizumab, to see if it helps manage their cancer better.

  Recruiting Phase 1 UNC Lineberger Comprehensive Cancer Center · Chapel Hill, North Carolina · NCT05542407

• Peptide Alarm Therapy for advanced or metastatic solid tumors

  The team will try injecting Peptide Alarm Therapy directly into tumors alongside standard IV PD‑1/PD‑L1 drugs for adults whose advanced or metastatic solid tumors progressed after prior treatments, including prior PD‑1/PD‑L1 therapy.

  Recruiting Phase 1 Masonic Cancer Center, University of Minnesota · Minneapolis, Minnesota · NCT05338658

• Combining Abemaciclib and Bicalutamide for Advanced Breast Cancer

  This study is testing if combining two drugs, Abemaciclib and Bicalutamide, can help people with advanced breast cancer feel better and live longer.

  Recruiting at 3 sites Phase 1/2 Icahn School of Medicine at Mount Sinai · New York, New York and 2 other locations · NCT05095207

• Using biopsies to improve diagnosis of rectal cancer after treatment

  This study is testing if using special biopsy techniques can help doctors more accurately determine if rectal cancer patients have fully responded to treatment before surgery.

  Recruiting Beijing Chao Yang Hospital · Beijing, Beijing Municipality · NCT04743102

• 68Ga-FAPI PET/CT imaging to detect primary and metastatic cancer lesions

  This study tests whether 68Ga-DOTA/NOTA-FAPI-04 PET/CT can help find primary tumors and metastases in adults with various cancers.

  Recruiting Early Phase 1 First Affiliated Hospital of Fujian Medical University · Fuzhou, Fujian · NCT04499365

• Comparing two types of PET scans for cancer diagnosis

  This study is testing whether a new type of PET scan can find cancer better than the standard scan in patients who have or might have tumors.

  Recruiting The First Affiliated Hospital of Xiamen University · Xiamen, Fujian · NCT04416165

• Analysis of liver metastasis in colorectal cancer

  This study is looking at the differences in proteins between normal colorectal tissue and colorectal cancer tissue with and without liver metastasis to see how these changes might help understand the disease better.

  Recruiting at 2 sites Shanghai 10th People's Hospital · Ganzhou, Jiangxi and 1 other locations · NCT02917707

NIH-funded research (newest 40 of 489)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Lymph node metastasis and immune tolerance in head and neck cancer

  A study in people with head and neck cancer looks at how cancer spread to lymph nodes may shape the immune system and help tumors grow.

  NIH research Stanford University · Stanford, United States · NIH-11614785

• Targeting how RMS cells fail to mature to slow or stop pediatric muscle cancer spread

  A project to understand why a pediatric muscle cancer called rhabdomyosarcoma spreads, and to test ideas that could slow or stop it by helping cancer cells mature properly.

  NIH research Purdue University · West Lafayette, United States · NIH-11609892

• Centers studying how cancer spreads through the body

  A multi-institutional project at Rockefeller University is exploring how nerves, blood vessels, lymphatics, immune cells, and metabolites influence the spread of cancer to help identify new ways to stop metastasis.

  NIH research Rockefeller University · New York, United States · NIH-11531592

• Angiopoietin-2 and Tie2 signals shaping liver metastasis in pancreatic neuroendocrine tumors

  A study explores how Angiopoietin-2 and the Tie2 receptor influence the spread of pancreatic neuroendocrine tumors to the liver and how this affects responses to immunotherapy.

  NIH research Columbia University Health Sciences · New York, United States · NIH-11473762

• Nanoparticles that boost MRI to find tiny brain metastases

  This uses tiny magnetic nanoparticles and new MRI image processing to help doctors find very small brain metastases earlier in people with cancer.

  NIH research University of California at Davis · Davis, United States · NIH-11467320

• Tumor-Niche Co-evolution in Ovarian Cancer Metastasis and Resistance

  This research explores how ovarian cancer cells interact with their surrounding tissue to understand how metastasis and resistance to therapy develop, with potential to guide better treatments.

  NIH research Ut Southwestern Medical Center · Dallas, United States · NIH-11464781

• Deep profiling of how fusion-driven pediatric cancers spread, using single-cell protein tools

  Researchers will develop fast, highly capable single-cell protein measurements to understand how certain pediatric cancers, like Ewing sarcoma, spread and evade the immune system.

  NIH research Rice University · Houston, United States · NIH-11457479

• 3D bone tissue models to study breast cancer spread to bone and stop it

  Aims to build a tunable 3D bone-like scaffold to study how breast cancer cells interact with bone and test early ways to prevent bone metastasis.

  NIH research University of Georgia · Athens, United States · NIH-11450920

• Camk2b loss fuels pancreatic cancer spread and immune suppression

  A new NIH grant seeks to understand why losing CAMK2B in pancreatic cancer makes the cancer spread more and suppresses immune responses, using advanced mouse models.

  NIH research Univ of Massachusetts Med Sch Worcester · Worcester, United States · NIH-11448883

• Cystine-limited stress and pancreatic cancer growth and spread

  Aims to understand how pancreatic cancer cells survive when the nutrient cystine is scarce and to find weak spots that could be targeted to slow or stop tumor growth and spread.

  NIH research Pennsylvania State Univ Hershey Med Ctr · Hershey, United States · NIH-11445541

• How the nucleus affects breast cancer spread and emerin’s role

  A researcher-led project at Rowan University is exploring how the cell nucleus and a protein called emerin influence the spread of breast cancer, especially the aggressive triple-negative type.

  NIH research Rowan University · Glassboro, United States · NIH-11444492

• How the tumor environment helps ovarian cancer spread by activating c‑Jun and AKT2

  This work looks for molecular changes in the tumor surroundings that switch on c‑Jun and AKT2 and help ovarian cancer cells spread, aiming to guide new treatments for people with metastatic ovarian cancer.

  NIH research University of New Mexico Health Scis Ctr · Albuquerque, United States · NIH-11437716

• TGFβ brakes immune evasion and metastasis in Ewing sarcoma during radiation

  A physician-scientist will study whether blocking TGFβ during radiation can help CAR T cells fight Ewing sarcoma and improve patient outcomes.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11435865

• Prolactin signaling and brain metastasis in HER2-positive breast cancer

  Researchers are studying how prolactin signals help HER2-positive breast cancer cells grow in the brain, with the goal of finding new ideas to prevent brain metastases.

  NIH research Columbia University Health Sciences · New York, United States · NIH-11434654

• PMN-MDSCs in bone metastasis of prostate cancer

  A study in people with advanced prostate cancer bone metastases is exploring how immune-suppressing cells in the bone environment may limit current therapies and how targeting them could help.

  NIH research University of Tx Md Anderson Can Ctr · Houston, United States · NIH-11424921

• ER+ Breast Cancer Bone Metastasis in a Real Body Environment

  This grant aims to understand why estrogen receptor alpha–positive breast cancer often spreads to bone and how the bone environment and immune system affect treatment resistance.

  NIH research Baylor College of Medicine · Houston, United States · NIH-11422333

• Stable, ultra-tight peptides to block EphB4 and stop TNBC spread

  A new peptide-based approach aims to block a cancer molecule called EphB4 to prevent metastasis in triple-negative breast cancer, especially in African American women.

  NIH research Texas Southern University · Houston, United States · NIH-11420423

• ATM kinase as a target to help NSCLC with brain metastases respond to treatment

  A study from Yale University tests whether blocking ATM kinase can delay or overcome treatment resistance in people with advanced non-small cell lung cancer that has spread to the brain and other organs.

  NIH research Yale University · New Haven, United States · NIH-11417454

• Understanding why some head and neck cancers stop responding to cisplatin and spread

  This project explores why certain head and neck cancers stop responding to cisplatin and how nerve signals inside tumors may drive metastasis, with goals that could lead to new ways to overcome drug resistance.

  NIH research University of Tx Md Anderson Can Ctr · Houston, United States · NIH-11416341

• How an immune signal in brain support cells helps breast cancer spread to the brain

  This project looks at whether a specific immune signal in brain support cells (astrocytes) helps breast cancer cells grow in the brain, aiming to help people with breast cancer that has spread to the brain.

  NIH research Research Inst of Fox Chase Can Ctr · Philadelphia, United States · NIH-11415817

• Focal Adhesion Kinase inhibitor to block osteosarcoma spread to the lungs

  A cancer treatment plan tests whether blocking a specific cell signal can stop osteosarcoma from growing and spreading to the lungs in kids and young people.

  NIH research Colorado State University · Fort Collins, United States · NIH-11415785

• Understanding cancer cell states and tumor ecosystems to inform treatment

  Researchers are studying how cancer cells and their surrounding environment evolve together to find better ways to treat aggressive tumors.

  NIH research Columbia University Health Sciences · New York, United States · NIH-11415685

• Brain cancer cells and brain cells talk to each other to spread to the brain

  A research project uses computer and mouse studies to understand how cancer cells that spread from breast or lung tumors grow in the brain and interact with brain support cells.

  NIH research Sloan-Kettering Inst Can Research · New York, United States · NIH-11415150

• Role of Prohibitin 1 in alcohol-related colorectal liver metastasis

  This grant studies how a protein called PHB1 in liver cells affects cancer spread to the liver in people who drink alcohol.

  NIH research Cedars-Sinai Medical Center · Los Angeles, United States · NIH-11413772

• Personalized Metastasis-Directed Therapy for Prostate Cancer with Imaging and Biopsy Boost

  A large North American trial will test whether targeted radiation to metastases helps men with a specific type of prostate cancer and uses biomarker tests and imaging to tailor treatment.

  NIH research Case Western Reserve University · Cleveland, United States · NIH-11411288

• How brain support cells' recycling affects breast cancer spread to the brain

  This project looks at whether blocking a cell-recycling process in brain support cells can prevent or slow breast cancer that spreads to the brain in people with breast cancer.

  NIH research Ohio State University · Columbus, UNITED STATES · NIH-11409057

• Differing NAD+ kinase roles in melanoma spread

  Researchers are studying how different NAD+ kinase forms affect the spread of melanoma, with the goal of finding new angles to prevent metastasis.

  NIH research Beth Israel Deaconess Medical Center · Boston, United States · NIH-11408660

• Targeting cancer spread by blocking curvature-driven survival signals

  A new treatment approach aims to block a hidden survival trick cancer cells use when they break away from tumors, helping prevent cancer from spreading.

  NIH research Stanford University · Stanford, United States · NIH-11408580

• Anti-MUC16 antibody combo to fight metastatic pancreatic cancer

  A new antibody-based treatment added to standard chemotherapy is being tested to slow or stop the spread of pancreatic cancer in preclinical models.

  NIH research Sanguine Diagnostics and Therapeutics · Omaha, United States · NIH-11408229

• Bone marrow signals that keep cancer cells asleep or wake them up and spread cancer

  A researcher plans to study how breast cancer cells hide in the bone marrow and what makes them wake up and form new tumors, with the goal of stopping relapse.

  NIH research University of Minnesota · Minneapolis, United States · NIH-11403903

• Understanding how chemotherapy affects breast cancer spread and liver immunity

  A research project looks at how standard breast cancer chemotherapy may change the immune system and cancer spread, especially to the liver, in people with aggressive breast cancer.

  NIH research Brigham and Women's Hospital · Boston, United States · NIH-11402772

• Enhanced Viro-Immunotherapy for Breast Cancer Brain Metastasis

  A study testing a virus-based cancer therapy to help treat breast cancer that has spread to the brain, with focus on boosting the body’s immune response to fight the tumors.

  NIH research University of Texas Hlth Sci Ctr Houston · Houston, United States · NIH-11402019

• Metastasis Research Network Center at NYU Langone Health

  A cancer center-led program aims to coordinate metastasis research activities across NYU Langone Health to advance understanding and treatment of metastatic cancer.

  NIH research New York University School of Medicine · New York, United States · NIH-11401362

• Understanding how palmitoylation affects Cadherin-Catenin cell adhesion and lung melanoma spread

  This NIH grant studies how a chemical modification called palmitoylation influences how melanoma cells stick together and spread to the lungs, with potential to improve future treatments.

  NIH research Cleveland Clinic Lerner Com-Cwru · Cleveland, United States · NIH-11400079

• Ceramide signals and PD-L1 help in triple-negative breast cancer spread and response to immunotherapy

  This grant tests how fat molecules inside TNBC cells influence PD-L1 and help cancer spread, with the goal of improving immunotherapy results for patients.

  NIH research Medical University of South Carolina · Charleston, United States · NIH-11399097

• A closer look at how the plantar skin environment shapes acral melanoma and its drug responses

  This grant studies how the special skin on the bottom of the foot affects acral melanoma and its resistance to treatments, with aims to guide better, future therapies for people with this cancer.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11397718

• Understanding how stress affects cancer spread and treatment outcomes

  A funded program at Johns Hopkins explores how stress hormones and the brain’s stress pathways influence cancer metastasis in animals, with the goal of improving care for patients with breast and pancreatic cancer.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11397593

• MKK4 and Liver Regeneration after Major Liver Surgery

  A study at Mayo Clinic will test a new drug, HRX215, to help people regrow liver tissue after major liver surgery for cancer.

  NIH research Mayo Clinic Rochester · Rochester, United States · NIH-11393014

• Tissue tension and cancer: how stiff tissues drive cancer growth and spread

  This NIH grant explores how stiff tissue environments and mechanical forces inside the body may promote cancer growth, aggression, and spread, with the goal of finding biomarkers and new drug targets that could help patients.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11392427

• Brain metastasis targeting and therapy in small cell lung cancer

  A new plan to study why small cell lung cancer spreads to the brain and how to treat those brain metastases with safer, more effective options.

  NIH research Ut Southwestern Medical Center · Dallas, United States · NIH-11391984

Related topics

Quick answers

How many Metastasis clinical trials are recruiting right now?

28, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 22 countries. The most sites are in China (13 trials), United States (9 trials), Spain (2 trials), Brazil (2 trials), France (2 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 3, Phase 1/2: 3, Early Phase 1: 2, Phase 1: 2. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.

Describe your situation →