Clinical trial Recruiting at 3 sites Interventional Ages 21 to 60

Community-based cognitive remediation program for schizophrenia and schizoaffective disorder

Official title: Integrative Neuro-social Cognitive Strategy Programme for Instilling REcovery (INSPIRE): a Community-Based Cognitive Remediation Trial

Run by Singapore Institute of Technology · NCT06286202 · Data updated 2026-11-12

This study tests a community program that helps adults with schizophrenia and schizoaffective disorder improve their thinking skills through exercises and group support to see if it makes their daily lives better.

Quick facts

Study typeInterventional
Ages21 Years to 60 Years
SexAll
Enrollment160 (estimated)
SponsorSingapore Institute of Technology
Academic / other
Locations5 sites (Singapore and 4 other locations)
StatusRecruiting
StartedAugust 6, 2024
Main results expectedJune 2027
Study endsDecember 2027
Registry record updatedJanuary 27, 2026
Trial IDNCT06286202 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are adults diagnosed with schizophrenia or schizoaffective disorder who have completed at least ten years of formal education and can converse in English.

Probably not a fit

Patients with neurological diseases, those unable to understand English, or those with very low functioning may not benefit from this program.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This program aims to improve cognitive skills in adults with schizophrenia and schizoaffective disorders through a community-based cognitive remediation approach. Participants will engage in a structured intervention that includes computer-assisted exercises and group sessions facilitated by therapists. The study will also explore how motivation and social interaction influence cognitive improvements and functional abilities. The focus is on addressing cognitive impairments that hinder community integration and quality of life.

Why it matters

Potential benefit: If successful, this program could enhance cognitive functioning and improve the quality of life for patients with severe mental illnesses.

How similar studies have gone: Previous studies have shown positive outcomes with cognitive remediation approaches, suggesting potential for success in this community-based setting.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* A diagnosis of schizophrenia or schizoaffective disorder according to Diagnostic and Statistical Manual of Mental Disorders-5th Edition (DSM-V).
* Completed at least ten years of formal education with English as the main instructional language. Participants need to be able to converse in English and understand English instructions, as the cognitive remediation program will be conducted in English.

Exclusion Criteria:

* Known neurological diseases and epilepsy, which affects gains from cognitive remediation.
* Unable to speak and understand English.
* Hospitalized within the past one month.
* Global Assessment of Functioning score of 30 or below, as participants who are too low functioning are unable to benefit from a strategy learning approach.

Where it's running

  • Anglican Care Center-Bukit Batok
    Singapore, Singapore
    Recruiting
  • Anglican Care Center-Hougang
    Singapore, Singapore
    Recruiting
  • Anglican Care Center-Simei
    Singapore, Singapore
    Recruiting
  • Anglican Care Center-Pasir Ris
    Singapore, Singapore
    Not yet recruiting
  • Anglican Care Center-Yishun
    Singapore, Singapore
    Not yet recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.