Condition

Rectal Neoplasms clinical trials and research

• 13Clinical trials
• 2New in 30 days
• 13Countries

Newest Rectal Neoplasms clinical trials

All recruiting trials (13)

• Characterization of the tumor microenvironment in locally advanced rectal cancer before and during neoadjuvant therapy

  This observational study tests how the tumor and immune cells change in locally advanced rectal cancer from baseline to during neoadjuvant therapy using advanced genomic and immune profiling.

  Recruiting Fujian Medical University Union Hospital · Fuzhou, Fujian · NCT07920770

• Neoadjuvant therapy for locally advanced low rectal cancer: adding fruquintinib to short-course radiotherapy with tislelizumab and CAPOX

  This study tests whether adding fruquintinib to short-course radiotherapy plus tislelizumab and CAPOX before surgery helps people with locally advanced low rectal cancer achieve a better tumor response.

  Recruiting Phase 2 Ruijin Hospital · Shanghai, Shanghai Municipality · NCT07888309

• Gut and tumor bacteria patterns in metastatic versus non-metastatic colorectal cancer

  This project will test whether bacteria in the gut and tumor differ between people whose colorectal cancer has spread and those whose cancer has not to see if bacterial signatures can help predict spread.

  Recruiting Sixth Affiliated Hospital, Sun Yat-sen University · Guangzhou, Guangdong · NCT07154173

• Comparing two surgical techniques for anal function after low rectal cancer surgery

  This study is testing which of two surgical methods helps people with ultra-low rectal cancer have better bowel control and quality of life after surgery.

  Recruiting Sixth Affiliated Hospital, Sun Yat-sen University · Guangzhou, Guangdong · NCT05943444

• Comparing treatment options for mid-low rectal cancer

  This study is testing different treatment options for mid-low rectal cancer to see which ones work best and are most cost-effective for patients and healthcare providers in China.

  Recruiting Peking Union Medical College Hospital · Beijing, Beijing Municipality · NCT05871762

• Platform program for evaluating treatments in metastatic HER2-positive breast cancer

  This study is testing different new treatments for people with advanced HER2-positive breast cancer to see which ones work best before moving them to larger trials.

  Recruiting at 5 sites Phase 1/2 QuantumLeap Healthcare Collaborative · Birmingham, Alabama and 9 other locations · NCT05868226

• Effects of aerobic exercise on muscle changes in colorectal cancer survivors

  This study tests if doing aerobic exercise can help improve muscle health in people who have survived colorectal cancer compared to those who are not exercising.

  Recruiting AdventHealth Translational Research Institute · Orlando, Florida · NCT05789433

• Robot-assisted reconstruction after surgery for rectal or anal cancer

  This study is testing if using a muscle flap to rebuild the pelvic floor or vagina after robotic surgery for rectal or anal cancer can improve recovery and quality of life for patients.

  Recruiting Oslo University Hospital · Oslo · NCT05689775

• Neoadjuvant chemoradiotherapy and chemotherapy for rectal cancer

  This study is testing if giving a combination of chemotherapy and radiation before surgery can help people with locally advanced rectal cancer do better than the usual treatment.

  Recruiting Larissa University Hospital · Larissa · NCT05496491

• Monitoring pelvic nerves during rectal cancer surgery

  This study is testing if using nerve monitoring during rectal cancer surgery can help patients avoid problems like incontinence and improve their quality of life after the operation.

  Recruiting Larissa University Hospital · Larissa · NCT04949646

• Evaluating the impact of MR-guided radiation therapy on cancer treatment outcomes

  This study is testing how using a special type of radiation therapy with real-time imaging can improve treatment results and quality of life for adults with cancer.

  Recruiting at 14 sites UMC Utrecht · Pittsburgh, Pennsylvania and 17 other locations · NCT04075305

• Non-surgical treatment for low rectal cancer after chemotherapy and radiation

  This study is testing if patients with low rectal cancer who respond well to chemotherapy and radiation can safely avoid surgery by being closely monitored instead.

  Recruiting Mount Sinai Hospital, Canada · Toronto, Ontario · NCT03179540

• Watchful waiting approach for rectal cancer treatment

  This study is testing a 'Watch and Wait' approach for rectal cancer patients who have had treatment to see if they can avoid surgery if their cancer responds well.

  Recruiting at 2 sites Sahlgrenska University Hospital · Gothenburg and 1 other locations · NCT03125343

Related topics

Quick answers

How many Rectal Neoplasms clinical trials are recruiting right now?

13, as of November 12, 2026. 2 of them were first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 13 countries. The most sites are in China (5 trials), United States (3 trials), Canada (2 trials), Greece (2 trials), Australia (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 1, Phase 1/2: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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