Effects of aerobic exercise on muscle changes in colorectal cancer survivors

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial aims to assess how aerobic exercise training influences intermuscular adipose tissue in survivors of colorectal cancer compared to a control group receiving attention. Participants will engage in structured aerobic exercise and progressive stretching, with eligibility criteria ensuring they have completed necessary cancer treatments and are ready to exercise. The study will measure changes in muscle composition and overall health outcomes in this population.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age ≥18 years
* Histologically confirmed stage I, II, or III colon or rectal cancer
* Completed surgical resection with curative intent
* Completed other cancer-directed treatments
* Engage in \<150 minutes per week of moderate- to vigorous-intensity structured endurance exercise
* No planned major surgery during the study period
* Readiness to exercise, as determined by a modified version of the Physical Activity Readiness Questionnaire
* Ability to provide written informed consent
* Provide written approval by a qualified healthcare professional
* Willing to be randomized

Exclusion Criteria:

* Evidence of metastatic or recurrent colorectal cancer
* Concurrently actively treated other (non-colorectal) cancer
* Scheduled to receive other postoperative cancer-directed treatment(s)
* Currently pregnant, breastfeeding, or planning to become pregnant within the next 24 weeks
* Currently participating in another study with competing outcomes
* Contraindications to magnetic resonance imaging
* Any dietary condition or restriction that would limit tolerance of a mixed meal challenge
* Any other cardiovascular, pulmonary, orthopedic, neurologic, psychiatric, or other condition that, in the investigator's opinion, would preclude participation or successful compliance with the protocol
* Any other situation that, in the opinion of the investigator, would negatively impact subject safety or successful compliance with the protocol

Where it's running

• AdventHealth
  Orlando, Florida, United States Recruiting

Study contacts

• Principal investigator: Justin C. Brown, Ph.D. — AdventHealth
• Study coordinator: Justin C. Brown, Ph.D.
• Email: Justin.Brown4@AdventHealth.com
• Phone: 407-303-5600

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.