Using cryobiopsy to diagnose progressive pulmonary fibrosis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical study aims to evaluate the diagnostic effectiveness and safety of transbronchial cryobiopsy (TBLC) in patients with progressive pulmonary fibrosis (PPF). Participants will be randomly assigned to receive either TBLC or traditional transbronchial lung biopsy (TBLB) to compare outcomes. The study will also assess the prognosis, health economics, and potential changes in therapeutic strategies for patients diagnosed with PPF using TBLC. The findings could provide valuable insights into the best diagnostic approaches for this condition.

Why it matters

Who can join: the full rules

Inclusion Criteria:

Patients with PPF, ≥18 years of age, unclassified ILD, HRCT ≤3 months, forced vital capacity (FVC)≥50% predicted value, pulmonary carbon monoxide diffusion (DLCO)≥35% predicted value, echocardiography ≤12 months, estimated pulmonary systolic blood pressure ≤40 mmHg, Body mass index (BMI)≤35 kg/m2.

Exclusion Criteria:

Patients with platelet counts below 50,000×109/L or International Normalized ratio of prothrombin time (INR) above 1.5 are not eligible for TBLC

Where it's running

• China-Japan Friendship Hospital
  Beijing, Beijing Municipality, China Recruiting

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.