Exploring genetic traits in pulmonary fibrosis
Official title: Genetic Polymorphisms in Idiopathic Pulmonary Fibrosis
Run by University of Pittsburgh · NCT00258570 · Data updated 2026-11-12
This study is trying to find out if certain genes affect how idiopathic pulmonary fibrosis develops and how it impacts lung healing in patients.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 2000 (estimated) |
| Sponsor | University of Pittsburgh Academic / other |
| Locations | 1 site (Pittsburgh, Pennsylvania) |
| Status | Recruiting |
| Started | January 2003 |
| Main results expected | July 2035 |
| Study ends | July 2035 |
| Registry record updated | August 31, 2026 |
| Trial ID | NCT00258570 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are adults aged 18 and older who have been diagnosed with pulmonary fibrosis.
✕Probably not a fit
Patients under 18 years of age or those with non-fibrotic interstitial lung disease may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study aims to identify specific genetic polymorphisms that may contribute to the development of idiopathic pulmonary fibrosis (IPF) and the varying patterns of inflammation and scarring in the lungs. By analyzing genetic traits in patients diagnosed with IPF, the study seeks to understand the molecular mechanisms underlying the disease and how these genetic factors influence lung repair processes. The research will involve characterizing candidate genes related to inflammation and tissue remodeling, correlating these genetic variations with clinical outcomes in patients. The ultimate goal is to enhance our understanding of IPF and improve patient management.
Why it matters
Potential benefit: If successful, this study could lead to personalized treatment strategies for patients with pulmonary fibrosis based on their genetic profiles.
How similar studies have gone: Other studies have shown promise in identifying genetic factors related to pulmonary diseases, suggesting that this approach may yield valuable insights.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * 18 years of age or older * Diagnosis of pulmonary fibrosis confirmed by physical examination, pulmonary function testing, chest X-ray, and computed tomography (CT) scans. * Adult patients who are seeking treatment at the Dorothy P. and Richard P. Simmons Center for Interstitial Lung Disease. Exclusion Criteria: * Under 18 years of age * Non-fibrotic ILD
Where it's running
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University of Pittsburgh
Pittsburgh, Pennsylvania, United States Recruiting
Study contacts
- Principal investigator: Kevin F Gibson, MD — University of Pittsburgh, Simmons Center for ILD
- Study coordinator: Michelle F MacPherson, MAT
- Email: macphersonmj@upmc.edu
- Phone: 412-647-4537
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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AccuPulmo CT Portal for Detecting Pulmonary Fibrosis on Chest CT
This study tests how well the AccuPulmo CT Portal can identify pulmonary fibrosis on existing chest CT scans from adults at Taichung Veterans General Hospital.
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Advanced imaging to see how immunosuppression affects lung fibrosis activity
This trial will test whether immunosuppression changes PET and MRI measurements of active collagen deposition and tissue injury in people with non‑IPF interstitial lung disease who are starting treatment.
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68Ga-NI-FAPI-04 PET/CT imaging to detect fibroblast activation in cancer, fibrotic, and heart diseases
This test will see if an injected PET tracer called 68Ga-NI-FAPI-04 can better show fibroblast activation in people with tumors, pulmonary fibrosis, certain autoimmune vascular diseases, hypertrophic cardiomyopathy, or other cardiovascular conditions.
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Home monitoring for patients with pulmonary fibrosis
This study tests if using home monitoring and video calls can help people with pulmonary fibrosis manage their condition as well as or better than regular clinic visits.
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Understanding genetic and environmental factors in pulmonary fibrosis
This study looks at how genes and environmental factors affect pulmonary fibrosis to help understand the disease better for people who have it.
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Identifying biomarkers for progressive pulmonary fibrosis in lung disease patients
This study is trying to find early signs that can help predict if adults with certain lung diseases will develop progressive pulmonary fibrosis over the next five years.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.