Exploring genetic traits in pulmonary fibrosis
Genetic Polymorphisms in Idiopathic Pulmonary Fibrosis
This study is trying to find out if certain genes affect how idiopathic pulmonary fibrosis develops and how it impacts lung healing in patients.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 2000 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | University of Pittsburgh Academic / other |
| Locations | 1 site (Pittsburgh, Pennsylvania) |
| Trial ID | NCT00258570 on ClinicalTrials.gov |
What this trial studies
This observational study aims to identify specific genetic polymorphisms that may contribute to the development of idiopathic pulmonary fibrosis (IPF) and the varying patterns of inflammation and scarring in the lungs. By analyzing genetic traits in patients diagnosed with IPF, the study seeks to understand the molecular mechanisms underlying the disease and how these genetic factors influence lung repair processes. The research will involve characterizing candidate genes related to inflammation and tissue remodeling, correlating these genetic variations with clinical outcomes in patients. The ultimate goal is to enhance our understanding of IPF and improve patient management.
Who should consider this trial
Good fit: Ideal candidates for this study are adults aged 18 and older who have been diagnosed with pulmonary fibrosis.
Not a fit: Patients under 18 years of age or those with non-fibrotic interstitial lung disease may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to personalized treatment strategies for patients with pulmonary fibrosis based on their genetic profiles.
How similar studies have performed: Other studies have shown promise in identifying genetic factors related to pulmonary diseases, suggesting that this approach may yield valuable insights.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * 18 years of age or older * Diagnosis of pulmonary fibrosis confirmed by physical examination, pulmonary function testing, chest X-ray, and computed tomography (CT) scans. * Adult patients who are seeking treatment at the Dorothy P. and Richard P. Simmons Center for Interstitial Lung Disease. Exclusion Criteria: * Under 18 years of age * Non-fibrotic ILD
Where this trial is running
Pittsburgh, Pennsylvania
- University of Pittsburgh — Pittsburgh, Pennsylvania, United States (Recruiting)
Study contacts
- Principal investigator: Kevin F Gibson, MD — University of Pittsburgh, Simmons Center for ILD
- Study coordinator: Michelle F MacPherson, MAT
- Email: macphersonmj@upmc.edu
- Phone: 412-647-4537
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.