Clinical trial Recruiting at 1 site Observational Ages 18 and up

Exploring genetic traits in pulmonary fibrosis

Official title: Genetic Polymorphisms in Idiopathic Pulmonary Fibrosis

Run by University of Pittsburgh · NCT00258570 · Data updated 2026-11-12

This study is trying to find out if certain genes affect how idiopathic pulmonary fibrosis develops and how it impacts lung healing in patients.

Quick facts

Study typeObservational
Ages18 Years and up
SexAll
Enrollment2000 (estimated)
SponsorUniversity of Pittsburgh
Academic / other
Locations1 site (Pittsburgh, Pennsylvania)
StatusRecruiting
StartedJanuary 2003
Main results expectedJuly 2035
Study endsJuly 2035
Registry record updatedAugust 31, 2026
Trial IDNCT00258570 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates for this study are adults aged 18 and older who have been diagnosed with pulmonary fibrosis.

Probably not a fit

Patients under 18 years of age or those with non-fibrotic interstitial lung disease may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to identify specific genetic polymorphisms that may contribute to the development of idiopathic pulmonary fibrosis (IPF) and the varying patterns of inflammation and scarring in the lungs. By analyzing genetic traits in patients diagnosed with IPF, the study seeks to understand the molecular mechanisms underlying the disease and how these genetic factors influence lung repair processes. The research will involve characterizing candidate genes related to inflammation and tissue remodeling, correlating these genetic variations with clinical outcomes in patients. The ultimate goal is to enhance our understanding of IPF and improve patient management.

Why it matters

Potential benefit: If successful, this study could lead to personalized treatment strategies for patients with pulmonary fibrosis based on their genetic profiles.

How similar studies have gone: Other studies have shown promise in identifying genetic factors related to pulmonary diseases, suggesting that this approach may yield valuable insights.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* 18 years of age or older
* Diagnosis of pulmonary fibrosis confirmed by physical examination, pulmonary function testing, chest X-ray, and computed tomography (CT) scans.
* Adult patients who are seeking treatment at the Dorothy P. and Richard P. Simmons Center for Interstitial Lung Disease.

Exclusion Criteria:

* Under 18 years of age
* Non-fibrotic ILD

Where it's running

  • University of Pittsburgh
    Pittsburgh, Pennsylvania, United States
    Recruiting

Study contacts

  • Principal investigator: Kevin F Gibson, MD — University of Pittsburgh, Simmons Center for ILD
  • Study coordinator: Michelle F MacPherson, MAT
  • Email: macphersonmj@upmc.edu
  • Phone: 412-647-4537

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.