Improving adherence to inhaled iloprost for pulmonary arterial hypertension

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Adults with invasively confirmed PAH who are using inhaled iloprost at a referral center will receive pharmacist-delivered guidance on inhaler technique and medication adherence. The intervention includes hands-on training, counseling about side-effect management, and periodic follow-up to reinforce correct use and dosing frequency. Study outcomes will include measures of medication adherence, inhalation technique, adverse events, and functional status. The goal is to see if pharmacist support can improve real-world use and tolerability of inhaled iloprost in PAH patients.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* "Adult patients aged ≥ 18 years, treated at the referral center for PH management at the Heart Institute of the University of São Paulo Medical School, with an invasive confirmed diagnosis of PAH (mean pulmonary arterial pressure \[mPAP\] greater than 20 mmHg at rest, pulmonary vascular resistance \[PVR\] equal to or greater than 2 Wood units, and pulmonary capillary wedge pressure \[PCWP\] equal to or less than 15 mmHg), and who have been using Iloprost.

Exclusion Criteria:

* Patients who are unable to perform the 6-minute walk test (6MWT) or who have experienced gastrointestinal bleeding within the 12 weeks prior to the start of the study will be excluded.

Where it's running

• Incor HCFMUSP
  São Paulo, São Paulo, Brazil Recruiting

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.