Impact of ambient air vs nasal liquid oxygen on exercise performance in pulmonary vascular disease

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

In this randomized cross-over study, adults with pre-capillary pulmonary hypertension (PAH) or chronic thromboembolic pulmonary hypertension (CTEPH) living in Switzerland undergo two 6-minute walk tests: one with ambient air and one with nasal liquid oxygen at about 4 L/min. Participants have a history of exercise-induced desaturation and are on stable therapy. The goal is to determine if nasal LOX affects walking distance versus breathing ambient air within the same individual. The trial uses a cross-over design to compare each participant under both conditions. Primary outcome is 6MWD under LOX versus ambient air.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* \- Minimum 18 years of age
* Written informed consent
* Patients with diagnosed pulmonary arterial hypertension (PAH), distal chronic thromboembolic pulmonary hypertension (CTEPH), chronic obstructive pulmonary disease (COPD) with emphysema, COPD without emphysema, or interstitial lung disease
* Former desaturation under exercise defined as SpO2-decrease \>3%
* Treated with a stable drug therapy (with no changes for at least 14 days prior to screening)

Exclusion Criteria:

* \- Severe hypoxemia needing supplemental oxygen therapy defined as PaO2 \< 6.9 kPa
* Inability or contraindications to undergo the investigated intervention
* Inability to follow the procedures of the study, e.g. due to language problems, psychological disorders, dementia, walk disability etc.

Where it's running

• University Hospital Zurich
  Zurich, Canton of Zurich, Switzerland Recruiting

Study contacts

• Principal investigator: Silvia Ulrich, Prof. Dr. med. — University Hospital Zurich, Department of Pulmonology
• Study coordinator: Silvia Ulrich, Prof. Dr. med.
• Email: silvia.ulrich@usz.ch
• Phone: +41442552220

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• Escalation options for PAH patients already on dual therapy

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.