Diagnostic innovations for detecting glaucoma in eyes with and without myopia
Diagnostic Innovations in Glaucoma Study
This project tests imaging and vision tests to see if they can better detect glaucoma or its worsening in adults with or without myopia.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 3000 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | University of California, San Diego Academic / other |
| Locations | 1 site (La Jolla, California) |
| Trial ID | NCT00221897 on ClinicalTrials.gov |
What this trial studies
DIGS/ADAGES is a longitudinal observational program that follows adults with glaucoma, glaucoma suspect, ocular hypertension, and healthy controls, typically with visits about every six months. The multi-center ADAGES arm harmonizes protocols across sites (including UCSD, Columbia, and UAB) to increase sample size and enable combined analyses across people of European and African descent. Participants undergo repeated visual field testing, optic nerve and retinal imaging (including OCT and retinal vascular imaging), and questionnaires about visual function and quality of life. The protocol excludes eyes or participants with other ocular or systemic conditions that affect vision, and aims to improve detection of glaucoma and monitoring of progression particularly in people with myopia and in diverse racial groups.
Who should consider this trial
Good fit: Adults aged 18 and older with or without myopia who are healthy controls, have glaucoma, are glaucoma suspects, or have ocular hypertension, with at least one eye with open angles and best corrected visual acuity of 20/40 or better, are ideal candidates.
Not a fit: People with other ocular or systemic conditions that affect visual function, prior complex intraocular surgery, medications that alter visual field sensitivity, or vision worse than 20/40 are unlikely to benefit from this protocol.
Why it matters
Potential benefit: If successful, the work could lead to earlier and more accurate detection of glaucoma and better monitoring of progression, especially for patients with myopia or from underrepresented racial groups.
How similar studies have performed: Long-term cohorts like DIGS and ADAGES have already generated important findings on structure–function relationships in glaucoma, though methods to improve detection in myopic eyes and diverse populations are still evolving.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion: * Subjects are healthy controls with or without myopia, and patients with or without myopia with a diagnosis of glaucoma, glaucoma suspect and ocular hypertension * They will be considered if they are above 18 years old. * There is no upper age limit * Subject are not restricted by gender, race or ethnicity. Exclusion: -Participants with other ocular or systemic conditions and treatment, which may affect visual function, are excluded.
Where this trial is running
La Jolla, California
- UCSD, Hamilton Glaucoma Center — La Jolla, California, United States (Recruiting)
Study contacts
- Principal investigator: Linda Zangwill, PhD — University of California, San Diego
- Study coordinator: Veronica Inpirom
- Email: vrubio@health.ucsd.edu
- Phone: 858-822-4669
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.