Lifestyle changes plus nightly CPAP for glaucoma in people with sleep apnea
Glaucoma Respsosne to Lifestyle Corrections in Sleep Apnea
This test checks whether adding a low-calorie diet and regular walking to nightly CPAP lowers eye pressure in people with high‑pressure open‑angle glaucoma who also have obstructive sleep apnea and obesity.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 40 (estimated) |
| Ages | 30 Years to 50 Years |
| Sex | All |
| Sponsor | Cairo University Academic / other |
| Locations | 1 site (Giza, Dokki) |
| Trial ID | NCT07447011 on ClinicalTrials.gov |
What this trial studies
Forty adults with high‑tension primary open‑angle glaucoma (intraocular pressure >21 mmHg), diagnosed obstructive sleep apnea, and obesity will be enrolled and split into two groups of 20 for three months. Both groups will use continuous positive airway pressure (CPAP) every night; one group will also follow lifestyle corrections consisting of a low‑calorie diet and three 40‑minute treadmill walking sessions per week. Intraocular pressure and other ophthalmic measures will be monitored over the three‑month intervention to compare outcomes between groups. The protocol focuses on short‑term IOP change as the primary outcome and feasibility of combining CPAP with structured lifestyle changes.
Who should consider this trial
Good fit: Adults with high‑tension primary open‑angle glaucoma (IOP >21 mmHg), confirmed obstructive sleep apnea, and obesity who can tolerate nightly CPAP and adhere to a diet and exercise program are ideal candidates.
Not a fit: Patients without OSA or obesity, those with normal‑tension glaucoma, or individuals with significant cardiac, renal, or hepatic disease—or who cannot tolerate CPAP or exercise—are unlikely to benefit or be eligible.
Why it matters
Potential benefit: If successful, adding diet and exercise to nightly CPAP could further reduce intraocular pressure and potentially slow glaucoma worsening in this specific patient group.
How similar studies have performed: Prior work has linked OSA and glaucoma and explored CPAP effects on eye measures, but using structured lifestyle interventions specifically to lower IOP in this population is relatively novel with limited direct evidence.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Obstructive sleep apnea patients * obese patients * glaucoma (open angle form with ocular hyoertension) Exclusion Criteria: cardiac patients renal patients hepatic patients
Where this trial is running
Giza, Dokki
- Cairo University — Giza, Dokki, Egypt (Recruiting)
Study contacts
- Principal investigator: Ali MA Ismail, lecturer — Cairo University
- Study coordinator: Ali MA Ismail, lecturer
- Email: ali.mohamed@pt.cu.edu.eg
- Phone: 01005154209
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.