Improving risk prediction for glaucoma in diverse populations
Prioritizing diversity in polygenic risk prediction of primary open-angle glaucoma
This study is looking to improve how we predict the risk of primary open-angle glaucoma in people of African ancestry, so that they can get better early diagnosis and treatment options based on their unique genetic background.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | East Carolina University NIH-funded |
| Lab location | 1 site (Greenville, United States) |
| Project ID | NIH-11002782 on NIH RePORTER |
What this research studies
This research focuses on enhancing the prediction of primary open-angle glaucoma (POAG) risk by including individuals of African ancestry, who are often underrepresented in genetic studies. The project aims to conduct large-scale analyses of genetic data to identify new risk factors for POAG specifically in African and African-descent populations. By developing polygenic risk scores that are more applicable to these groups, the research seeks to improve early diagnosis and treatment options for glaucoma. Patients may benefit from more accurate risk assessments and tailored prevention strategies based on their genetic background.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals of African ancestry who may be at risk for primary open-angle glaucoma.
Not a fit: Patients of non-African ancestry may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to better risk prediction and earlier intervention for glaucoma in individuals of African ancestry.
How similar studies have performed: Previous research has shown that increasing diversity in genetic studies can lead to significant advancements in understanding disease risk, making this approach promising.
Where this research is happening
Greenville, United States
- East Carolina University — Greenville, United States (Active)
Researchers
- Principal investigator: Cooke Bailey, Jessica N — East Carolina University
- Study coordinator: Cooke Bailey, Jessica N
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.