Condition

Premature Birth clinical trials and research

• 34Clinical trials
• 1NIH research projects
• 19Countries

Newest Premature Birth clinical trials

All recruiting trials (34)

• Wireless MicroPremVitals Button Sensor for the NICU

  This study tests a tiny wireless sensor system to monitor heart rate, oxygen, and temperature in extremely preterm babies in the NICU to see if it works safely without wires.

  Recruiting McGill University Health Centre/Research Institute of the McGill University Health Centre · Montreal, Quebec · NCT07732257

• Caffeine in pregnancy: how the mother and baby handle it during delivery

  This study tests how caffeine is processed in pregnant people and how much reaches the baby when given shortly before delivery.

  Recruiting Phase 1 Indiana University · Indianapolis, Indiana · NCT07570121

• Neonatal data and biobank to understand what influences development in very preterm infants

  This project will collect clinical information and biological samples to see if early biological, clinical, and environmental factors predict short- and long-term development in infants born before 32 weeks or under 1500 g.

  Recruiting University Hospital of Cologne · Cologne, North Rhine-Westphalia · NCT07490912

• Biomarkers in infants with prior neonatal brain injury

  This project will test brain activity and development using games, EEG, and parent questionnaires in infants aged 3–24 months with and without prior neonatal brain injury.

  Recruiting University of Wisconsin, Madison · Madison, Wisconsin · NCT07413900

• PIOMI plus time‑based feeding to help preterm babies start oral feeds and gain weight

  We will test whether a specific oral‑motor routine (PIOMI) and a time‑based (chronobiological) feeding approach help preterm infants born at 29–33 weeks begin oral feeding sooner and gain weight better.

  Recruiting Aydin Adnan Menderes University · Aydin · NCT07306793

• Home air purifier to support lung recovery in babies born prematurely

  This tests whether using an air purifier at home improves breathing and oxygen levels in babies who were born prematurely.

  Recruiting Kaohsiung Medical University Chung-Ho Memorial Hospital · Kaohsiung City · NCT07236996

• Adding azithromycin to ampicillin for late PPROM

  This test sees if adding a single dose of azithromycin to the usual ampicillin/amoxicillin treatment helps newborns when membranes break early between 34.0 and 36.6 weeks.

  Recruiting Phase 4 Sheba Medical Center · Ramat Gan, Israel · NCT07183462

• Impact of wearable breast pumps on milk expression in mothers of premature infants

  This study tests whether using a new wearable breast pump can help mothers of premature infants express more milk compared to their usual hospital-grade pump.

  Recruiting University of Texas at Austin · Austin, Texas · NCT06723067

• Virtual intervention for at-risk children with neurological issues

  This study is testing if a virtual program can help young children with neurological issues, like those born prematurely, just as well as in-person help does.

  Recruiting University of Wisconsin, Madison · Madison, Wisconsin · NCT06643598

• Comparing iron supplementation methods in premature babies

  This study is testing if giving iron to premature babies four times a week instead of every day can help their blood levels while causing less tummy pain and constipation.

  Recruiting at 2 sites University Hospital, Geneva · Geneva, Canton of Geneva and 1 other locations · NCT06624709

• Evaluating a new surfactant treatment for respiratory distress in preterm infants in Africa

  This study is testing a new way to give surfactant treatment to preterm infants with breathing problems in Africa to see if it helps them do better than the usual care.

  Recruiting at 2 sites Phase 4 Indiana University · Bangui and 7 other locations · NCT06554522

• Support for new parents in the NICU

  This study tests whether having a doula to support new parents in the NICU can help reduce stress and anxiety for those with preterm infants, especially for families from low-income backgrounds.

  Recruiting University of Pennsylvania · Philadelphia, Pennsylvania · NCT06521398

• Using nerve stimulation to help premature infants breastfeed better

  This study is testing if a gentle nerve stimulation can help premature and sick term babies learn to breastfeed better while they're in the NICU.

  Recruiting Medical University of South Carolina · Charleston, South Carolina · NCT06417385

• Caffeine citrate loading dose before extubation in preterm infants

  This study tests if giving a dose of caffeine to preterm babies before they are taken off the ventilator can help them breathe better and stay off the machine successfully.

  Recruiting at 2 sites Phase 4 Semmelweis University · Budapest and 1 other locations · NCT06401083

• Understanding the impact of air pollution on premature birth

  This study is trying to see if air pollution affects the chances of having a premature baby by looking at health records from 18,000 patients.

  Recruiting at 2 sites Queen Mary University of London · London and 1 other locations · NCT06340971

• Predicting premature births using vaginal microbiota analysis

  This study is testing if analyzing the bacteria in the vagina can help predict premature births in pregnant women who are at risk.

  Recruiting University Hospital, Clermont-Ferrand · Clermont-Ferrand · NCT06265740

• Understanding how nutrition affects growth in premature infants

  This study looks at how the food that premature babies eat in the NICU affects their growth and development over three years.

  Recruiting University of Wisconsin, Madison · Madison, Wisconsin · NCT06226051

• Evaluating the impact of discharging premature newborns weighing less than 2 kilos

  This study looks at how discharging premature newborns who weigh less than 2 kilos affects their health and survival, by gathering feedback from parents about their experiences.

  Recruiting Hôpital NOVO · Pontoise · NCT06224764

• Understanding motor behavior in high-risk infants

  This study is trying to understand how movement and muscle development in high-risk infants, like those born early or with brain injuries, compare to typically developing infants to help find better ways to support their growth.

  Recruiting University Hospital, Geneva · Geneva · NCT06111898

• A device to help preterm infants differentiate speech sounds

  This study is testing a new device that helps preterm infants learn to tell different speech sounds apart by using a pacifier that plays their mother's voice.

  Recruiting Thrive Neuromedical, LLC · Atlanta, Georgia and 1 other locations · NCT06063122

• Cervical cerclage for preventing premature birth in high-risk pregnancies

  This study is testing if a procedure called cervical cerclage can help prevent early birth in pregnant people who are at high risk due to a short cervix.

  Recruiting at 2 sites Thomas Jefferson University · Charlotte, North Carolina and 1 other locations · NCT06036446

• Minimally invasive surfactant treatment for preterm infants

  This study is testing if giving a special lung treatment right after birth using a gentle method can help very premature babies breathe better compared to waiting until they need extra oxygen.

  Recruiting Phase 4 Endeavor Health · Evanston, Illinois · NCT06007547

• Measuring stress in fathers of preterm and term infants using hair cortisol

  This study looks at stress levels in fathers of preterm babies compared to those with full-term babies by testing their hair for cortisol and checking in with them over six months.

  Recruiting University of Cologne · Cologne, Northrhine-westfalia · NCT05969431

• Registry of outcomes and practices for extremely premature infants

  This study is trying to gather information about the health and care of extremely premature infants born at 22-23 weeks to help improve their treatment and outcomes.

  Recruiting at 59 sites The University of Texas Health Science Center, Houston · Birmingham, Alabama and 58 other locations · NCT05685745

• Effects of moderate preterm birth on language development

  This study is testing how being born a bit early affects language skills in babies, to help identify those who might need extra support as they grow.

  Recruiting Assistance Publique Hopitaux De Marseille · Marseille · NCT05397197

• Understanding long-term effects of breathing patterns in preterm infants

  This study looks at how breathing problems in preterm babies might affect their chances of developing asthma, sleep issues, and learning difficulties as they grow up.

  Recruiting Ann & Robert H Lurie Children's Hospital of Chicago · Chicago, Illinois · NCT05336890

• Movement imitation therapy for preterm infants

  This study is testing whether a special movement therapy that parents can do with their preterm infants helps improve their motor skills compared to standard care.

  Recruiting at 3 sites Institut d'Investigació Biomèdica de Girona Dr. Josep Trueta · Barcelona, Barcelona and 2 other locations · NCT05319158

• A decision support tool for families facing preterm delivery decisions

  This study is testing a new tool to help families make better decisions about care for their premature babies born between 22 and 26 weeks of pregnancy.

  Recruiting at 12 sites Indiana University · San Diego, California and 11 other locations · NCT05264779

• Single dose of corticosteroids for pregnant individuals at risk of preterm delivery

  This study is testing if a single lower dose of a corticosteroid can help pregnant people at risk of preterm delivery have healthier babies compared to the usual double dose.

  Recruiting at 16 sites Phase 4 McMaster University · Calgary, Alberta and 24 other locations · NCT05114096

• Responsive parenting intervention for toddlers born preterm

  This study is testing if a special program can help parents be more responsive to their toddlers who were born early, to see if it improves the children's development and brain growth.

  Recruiting The University of Texas Health Science Center, Houston · Houston, Texas · NCT04856501

• Intervention program for neurodevelopment in preterm infants

  This study is testing a program that helps very preterm infants develop better by providing early support and guidance to their families from trained professionals.

  Recruiting at 7 sites University Hospital, Brest · Angers and 8 other locations · NCT04685356

• Mueller polarimetric colposcopy to detect cervical changes during pregnancy.

  This project will try a special Mueller polarimetric colposcopy scan during pregnancy to see if it can predict when a person will give birth and help screen for risk of preterm birth.

  Recruiting Assistance Publique - Hôpitaux de Paris · Le Kremlin-Bicêtre, France · NCT04661553

• Improving family counseling for extremely preterm deliveries

  This study is trying to improve how doctors talk to families about extremely preterm deliveries to make sure they feel understood and supported during a tough time.

  Recruiting at 3 sites Boston Children's Hospital · Boston, Massachusetts and 2 other locations · NCT03819933

• Registry for Preterm Premature Rupture of Membranes

  This study is collecting information about pregnancies affected by early water breaking to see what causes it and how to improve care for both moms and babies.

  Recruiting American Alliance for pProm Support · Denver, Colorado · NCT02997345

NIH-funded research (1)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Understanding how premature birth affects math skills and the brain

  This study looks at why children born early may have more trouble with math and how parents and the brain relate to those challenges.

  NIH research University of Iowa · Iowa City, United States · NIH-11416717

Related topics

Quick answers

How many Premature Birth clinical trials are recruiting right now?

34, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 19 countries. The most sites are in United States (16 trials), France (5 trials), Germany (3 trials), Canada (3 trials), Spain (2 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 4: 5, Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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