Minimally invasive surfactant treatment for preterm infants

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates whether administering exogenous surfactant prophylactically in the delivery room using a minimally invasive technique can improve outcomes for preterm infants born between 22 and 29 weeks of gestation. It is a multicenter, randomized, controlled trial comparing this approach to rescue treatment administered if the infant requires additional oxygen support shortly after birth. The trial will involve several hospitals, with Northshore Evanston Hospital as the primary site, and aims to enroll infants who meet specific gestational age criteria while excluding those with congenital anomalies or alternative causes of respiratory distress.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Gestational age \<30 weeks
* Antenatal consent from Parent

Exclusion Criteria:

* Congenital anomalies
* Alternate cause of respiratory distress

Where it's running

• Northshore University Healthsystem
  Evanston, Illinois, United States Recruiting

Study contacts

• Principal investigator: Matthew Derrick, MBBS — Northshore Univ Healthsystem
• Study coordinator: Matthew Derrick, MBBS
• Email: mderrick@northshore.org
• Phone: 8475702920

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Wireless MicroPremVitals Button Sensor for the NICU

  This study tests a tiny wireless sensor system to monitor heart rate, oxygen, and temperature in extremely preterm babies in the NICU to see if it works safely without wires.

  Recruiting McGill University Health Centre/Research Institute of the McGill University Health Centre · Montreal, Quebec · NCT07732257

• Caffeine in pregnancy: how the mother and baby handle it during delivery

  This study tests how caffeine is processed in pregnant people and how much reaches the baby when given shortly before delivery.

  Recruiting Phase 1 Indiana University · Indianapolis, Indiana · NCT07570121

• LISA versus endotracheal surfactant distribution in preterm babies

  This pilot trial tests whether giving surfactant through a thin catheter (LISA) or through a breathing tube leads to more even surfactant spread in preterm infants with respiratory distress.

  Recruiting Hamad General Hospital · Doha · NCT07514481

• Neonatal data and biobank to understand what influences development in very preterm infants

  This project will collect clinical information and biological samples to see if early biological, clinical, and environmental factors predict short- and long-term development in infants born before 32 weeks or under 1500 g.

  Recruiting University Hospital of Cologne · Cologne, North Rhine-Westphalia · NCT07490912

• Lung ultrasound score to guide surfactant timing in preterm newborns

  This study tests whether using a lung ultrasound score can speed up diagnosing severe RDS and getting surfactant to moderately and late-preterm babies in the NICU.

  Recruiting Hackensack Meridian Health · Hackensack, New Jersey · NCT07442669

• Biomarkers in infants with prior neonatal brain injury

  This project will test brain activity and development using games, EEG, and parent questionnaires in infants aged 3–24 months with and without prior neonatal brain injury.

  Recruiting University of Wisconsin, Madison · Madison, Wisconsin · NCT07413900

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.