Registry for Preterm Premature Rupture of Membranes

Patient Registry for Women Diagnosed With Preterm Premature Rupture of Membranes or PPROM During Pregnancy

Observational American Alliance for pProm Support · NCT02997345

This study is collecting information about pregnancies affected by early water breaking to see what causes it and how to improve care for both moms and babies.

Quick facts

Study typeObservational
Enrollment3000 (estimated)
Ages14 Years to 55 Years
SexFemale
SponsorAmerican Alliance for pProm Support Academic / other
Locations1 site (Denver, Colorado)
Trial IDNCT02997345 on ClinicalTrials.gov

What this trial studies

The PPROM Registry aims to gather comprehensive data on pregnancies affected by Preterm Premature Rupture of Membranes (PPROM) before 37 weeks. It seeks to identify potential causes of PPROM, evaluate management trends, and assess both maternal and fetal care practices. By analyzing short-term and long-term outcomes of affected pregnancies, the registry aims to fill gaps in current knowledge and improve care protocols. This observational study will provide a large cohort of data, which is currently lacking in existing literature.

Who should consider this trial

Good fit: Ideal candidates for this registry are women diagnosed with Preterm Premature Rupture of Membranes before 37 weeks of pregnancy.

Not a fit: Patients who do not have a clinical diagnosis of PPROM or those diagnosed with PROM beyond 37 weeks may not benefit from this registry.

Why it matters

Potential benefit: If successful, this registry could lead to improved management strategies and outcomes for pregnancies affected by PPROM.

How similar studies have performed: This registry represents a novel approach, as few recent studies have focused on PPROM with large sample sizes and comprehensive follow-up.

Eligibility criteria

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Women diagnosed with Preterm Premature Rupture of Membranes (PPROM) prior to 37 weeks of pregnancy

Exclusion Criteria:

* Those without a clinical diagnosis or confirmation of PPROM in pregnancy
* Diagnosis of PROM beyond 37 weeks of pregnancy

Where this trial is running

Denver, Colorado

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions Fetal Membranes, Premature RupturePreterm Premature Rupture of the MembranesOligohydramniosPremature BirthPPROM
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.