Serpentine vs Hydrophilic Guidewire for tricky radial arteries
Official title: Comparison of the "Serpentine" Technique Versus Hydrophilic Guidewire 0,035'' for Navigating Radial and Brachial Artery Loops, Tortuosity and Sharp Angulation During Transradial Access.
Run by University Hospital of Patras · NCT07707427 · Data updated 2026-11-12
This study tests whether the Serpentine technique can improve success and safety when performing coronary procedures through a radial artery with loops or tortuosity.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 204 (estimated) |
| Sponsor | University Hospital of Patras Academic / other |
| Drugs / interventions | radiation |
| Locations | 1 site (Pátrai) |
| Status | Recruiting |
| Started | May 14, 2026 |
| Main results expected | May 2029 |
| Study ends | November 2029 |
| Registry record updated | July 16, 2026 |
| Trial ID | NCT07707427 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults (18+) with feasible transradial access and documented radial/brachial artery loop or tortuosity indicated for coronary angiography or PCI.
✕Probably not a fit
Patients without radial artery anatomical challenges or those with contraindications to the transradial approach may not benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
Patients needing coronary angiography or PCI through the radial artery who have known radial artery looping or tortuosity are evaluated to compare two approaches: the Serpentine technique versus the standard hydrophilic 0.035'' guidewire method. The study focuses on effectiveness, procedural time, and safety outcomes without using any new devices. Both techniques use standard materials and differ mainly in operator handling and manipulation. Results could influence how interventionalists approach challenging radial anatomy.
Why it matters
Potential benefit: If successful, the Serpentine technique could reduce procedure time and complications when access is anatomically challenging.
How similar studies have gone: Prior reports describe both techniques, with the hydrophilic approach being more common; the Serpentine method is emerging and its comparative benefit is still being clarified.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age ≥18 years * Feasibility of TRA * Indication for coronary angiography * Angiographic documentation of radial or brachial artery loop/tortuosity * Written informed consent Exclusion Criteria: * STEMI - high risk NSTEMI presentation * Hemodynamic instability * Anatomical contraindications (e.g., arteriovenous fistula) * Significant calcification of the radial or brachial artery on angiographic evaluation.
Where it's running
-
University Hospital of Patras
Pátrai, Greece Recruiting
Study contacts
- Principal investigator: Grigorios Tsigkas, MD, PhD — University Hospital of Patras
- Study coordinator: Grigorios Tsigkas, MD, PhD
- Email: gregtsig@hotmail.com
- Phone: +306974466662
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.