Cold-region exposure and heart remodeling after PCI

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This multicenter, prospective observational cohort study will examine if cumulative cold-region exposure prior to PCI is associated with adverse left ventricular remodeling and cardiovascular events after successful PCI. Researchers will quantify cold exposure through residence and work in cold regions over the 3 years before PCI, plus meteorological and outdoor work data. Participants will have baseline CMR, echocardiography, ECG, and clinical labs, with a 6-month echo follow-up to assess remodeling and ongoing capture of cardiovascular events. The study aims to link imaging phenotypes with environmental exposure to understand potential prognostic implications. Interventions are not part of this observational design.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age 18 to 75 years. Angiographically confirmed coronary artery disease treated with successful percutaneous coronary intervention, defined as residual stenosis \<30% with final TIMI grade 3 flow.

Clinically stable after PCI. Expected survival of at least 12 months. Able and willing to undergo baseline cardiovascular magnetic resonance imaging and baseline and 6-month transthoracic echocardiography.

Able to provide residential, occupational, training/deployment, and other relevant exposure histories for the 3 years preceding PCI.

Written informed consent provided.

Exclusion Criteria:

* Severe valvular heart disease, cardiomyopathy, congenital heart disease, or other major structural heart disease.

Previous coronary artery bypass grafting or heart transplantation. End-stage heart failure or New York Heart Association class IV heart failure. Severe renal dysfunction, defined as estimated glomerular filtration rate \<30 mL/min/1.73 m².

Known contraindication to cardiovascular magnetic resonance imaging or gadolinium-based contrast agents.

Inability to complete transthoracic echocardiographic assessment. Inability to reliably recall or verify major residential or occupational exposure history during the 3 years preceding PCI.

More than five major changes in primary residence during the 3 years preceding PCI that preclude reliable estimation of cumulative cold-region exposure.

Where it's running

• Chinese PLA General Hospital
  Beijing, Please Select An Option Below, China Recruiting

Study contacts

• Study coordinator: Geng Qian, PhD
• Email: a2013346@hotmail.com
• Phone: 010499422

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.