Surgical repair of cartilage to prevent osteoarthritis later in life
Official title: Cell Therapy for Osteoarthritis
Run by Robert Jones and Agnes Hunt Orthopaedic and District NHS Trust · NCT07320118 · Data updated 2026-11-12
This project will see if surgical treatments for cartilage defects (such as ACI) reduce the chance of developing osteoarthritis later in people who had cartilage repair or alternative treatments.
Quick facts
| Study type | Observational |
|---|---|
| Sex | All |
| Enrollment | 650 (estimated) |
| Sponsor | Robert Jones and Agnes Hunt Orthopaedic and District NHS Trust Government |
| Locations | 2 sites (Oswestry and 1 other locations) |
| Status | Recruiting |
| Started | April 13, 2010 |
| Main results expected | January 12, 2030 |
| Study ends | January 12, 2030 |
| Registry record updated | January 8, 2026 |
| Trial ID | NCT07320118 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are people who previously had ACI or another surgical cartilage repair and can provide medical records and follow-up information.
✕Probably not a fit
People who have not had cartilage repair surgery or who cannot provide follow-up data or attend the study site are unlikely to benefit from participation.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This is an observational cohort effort based at the Robert Jones and Agnes Hunt Orthopaedic Hospital with collaboration from Keele University, following patients who have received autologous chondrocyte implantation (ACI) or alternative cartilage treatments. Investigators will collect existing clinical records, imaging, and patient-reported outcome data to compare long-term development of osteoarthritis between treatment groups. No new interventions are given; analyses will look for associations between the type of cartilage treatment and later OA outcomes. The findings aim to inform whether certain surgical approaches are associated with lower risk of developing osteoarthritis over time.
Why it matters
Potential benefit: If successful, the results could help doctors choose cartilage repair methods that lower patients' risk of developing osteoarthritis later in life.
How similar studies have gone: Prior observational cohorts and surgical series have reported mixed evidence that cartilage repair may delay OA, with limited long-term randomized data available.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * ACI patients or patients receiving an alternative treatment Exclusion Criteria: * Anyone who does not meet the inclusion criteria
Where it's running
-
The Robert Jones and Agnes Hunt Orthopaedic Hospital
Oswestry, United Kingdom Recruiting -
Robert Jones and Agnes Hunt Orthopaedic hospital
Oswestry, United Kingdom Recruiting
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.