Impact of pre-operative sarcopenia on recovery after hip replacement in older adults

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This exploratory, single-centre study at Montpellier University Hospital will enroll about 20 participants aged 75 or older undergoing hip arthroplasty for hip fracture or severe OA. Researchers will measure pre-operative sarcopenia through blood biomarkers, imaging, and a small muscle biopsy taken during surgery, then assess functional recovery at 3 and 6 months using the Barthel Index. Additional data will include MRI of thigh muscles and a low-dose bone scan to characterize muscle and bone health, with questionnaires and functional tests completed when feasible. The goal is to see if pre-operative muscle status modulates post-operative recovery, potentially informing rehabilitation strategies.

Why it matters

Who can join: the full rules

Inclusion Criteria:

\- Elderly subjects undergoing surgical hip replacement for fracture of the upper end of the femur or severe hip osteoarthritis.

Exclusion Criteria for both groups :

* Contraindications to MRI : pacemaker, metallic implants.
* Presence of a lower-limb prosthesis on the contralateral side to the surgery that may interfere with quadriceps mass measurements.
* Progressive high-grade neoplasia.
* Documented major cognitive disorders
* Under legal protection measures (guardianship, conservatorship, or curatorship).
* Subjects not affiliated with or not covered by a social security system.
* Participation in another ongoing study with an active exclusion period.

Exclusion criteria - Fracture group :

* Fracture with a suspicion of underlying neoplasia.
* Placement of a lower-limb prosthesis on the surgical side within the last 12 months.
* Inability to walk with or without human/technical assistance prior to fracture.

Exclusion criteria - Hip osteoarthritis group :

\- Active inflammatory joint disease (rheumatoid arthritis, spondyloarthritis).

Where it's running

• University Hospital
  Montpellier, France Recruiting

Study contacts

• Study coordinator: Jean Baptiste ROBIAUD, Assistant head physician
• Email: jbrobiaud@gmail.com
• Phone: +33629184092

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.